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Sudden Death
Patho Final
11
Pathology
Post-Graduate
10/28/2012

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Cards

Term
Commotio Cordis
Definition
"the innocent blow"
15-30 ms prior to peak of T wave (when it hits, not where)
Term
Hypertrophic cardiomyopathy
Definition
disorganized cellular architecture, LV wall thickness >15mm
MC mutations of sarcomere proteins
Term
Idiopathic concentric LVH
Definition
no cellular disarray, no known genetic transmission
Term
Anomalous Coronaries
Definition
deadly when both originate from left/right sinus of valsalva
Term
Arrhythmogenic right ventricular dysplasia
Definition
fibrofatty infiltration of muscle, causes thinning leading to aneurysms
Term
Mitral valve prolapse
Definition
increase risk of SD 10-15X
Term
Myocarditis
Definition
Coxsackie virus B: progressively worsening exercise intolerance, dyspnea, cough, orthopnea
Term
Congenital long QT
Definition
genetic "channelopathy" caused by mutations in either the K+ or Na+ channels
Term
Brugada syndrome
Definition
"channelopathy" caused by a Na+ channel mutation
Term
Marfan syndrome
Definition
genetic alteration of FBN 1 gene
Armspan longer than height, pectus excavatum, arachnodactyly, dilation of aorta, wrist/thumb sign, ectopia lentis
Term
Sickle cell trait
Definition
cramping (without twinges [heat cramp])
less sever pain than heat cramps
collapse due to weakness (instead of hobbling)
faster recovery than heat cramps
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