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Structure and function of viruses
ONU med micro r-anderson
55
Microbiology
Undergraduate 2
09/20/2011

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Cards

Term
Types of viruses (host)
Definition
plants, bacteria, animals
Term
types of viruses (structure)
Definition
nucleic acid type, capsid shape, enveloped or not enveloped
Term
types of viral nucleic acids
Definition
ssDNA, dsDNA, ssRNA, dsRNA
Term
types of viral capsids
Definition
helical, polyhedral, complex
Term
envelope
Definition
phospholipid bilayer remnant of host cell
surounds capsid
Term
steps of viral replication
Definition
attachment, entry, gene expression, viral assembly, release of new virions
Term
virion def
Definition
fully functional virus
Term
steps of viral gene expression
Definition
mRNA transcription, protein synthesis, nucleic acid replicaiton
Term
bacteriophage release mechanism
Definition
lytic cycle
Term
lytic cycle def
Definition
virus destroys cell to release new virions
Term
bacteriophage capsid shape
Definition
complex - polyhedral head, helical sheath attached to head
Term
adhesion location
Definition
ends of tail fibers of virus
Term
adhesin structure
Definition
protein
Term
receptor locaiton
Definition
cell membrane of host cell
Term
receptor structure
Definition
protein, carb, gylcoprotein virus has evolved to attach to
Term
attachment of bacteriophage
Definition
attaches to host at tail fibers and baseplate
Term
entry of bacteriophage
Definition
phage penetrates host cell with tail core through sheath contraction
Term
gene expression of bacteriophage
Definition
VDNA -->VmRNA-->VProteins-->Vparts
|
->VDNA
Term
assembly of bacteriphage
Definition
viral components assemble spontaneously
Term
release of bacteriophage - last enzyme made?
Definition
lysisizime
Term
lysiszime function
Definition
weaken cell membrane
Term
HIV classification
Definition
animal retrovirus
Term
HIV genetic information
Definition
ssRNA
Term
HAART stands for...
Definition
highly active anti-retroviral therapy
Term
HAART also know as
Definition
triple cocktail
Term
HAART targets
Definition
2 target reverse transcriptase and 1 targets protease
Term
HIV structure (genetic info, shape, e or non-e)
Definition
ssRNA, icoshedral, enveloped
Term
HIV adhesin
Definition
gp120
Term
HIV receptor
Definition
CD4
Term
HIV entry through what protein
Definition
gp41
Term
cells targeted by HIV
Definition
Neurons, T4 lymphocytes, macrophages
Term
HIV polyprotein
Definition
p7-p17-p24-Reverse transcriptase-integrase-protease
Term
Steps of HIV entry
Definition
membrane fusion and capsid uncoating
Term
HIV step of reverse transcriptase
Definition
ssRNA turns into dsDna
Term
HIV step of integration
Definition
viral DNA moves into nucleus
Term
HIV step of gene expression
Definition
vDNA-->vmRNA-->vproteins
Term
Steps of HIV assembly
Definition
p7 binds to HIV RNA
p17 binds to cell membrane
protease cuts polyprotein
Term
protease cutting polyprotein causes...
Definition
spontaneous assembly of virus
Term
HIV releases by...
Definition
budding
Term
envelope protein of HIV
Definition
gp 160
Term
gp160 made of...
Definition
gp120 and gp41
Term
is gp41 hydrophobic or hydrophillic
Definition
phobic
Term
what is p17
Definition
matrix protein
Term
major antigen of HIV
Definition
p24
Term
what is p24's role
Definition
capsid protein
Term
what is p7
Definition
ribonucleoprotein - binds to RNA
Term
reverse transcriptase
Definition
turns RNA into DNA
Term
intergrase
Definition
incorporates viral DNA into host cell DNA
Term
protease
Definition
cuts polyprotein into pieces so they can assemble
Term
gag gene codes for
Definition
p24 and other capsid proteins
Term
pol gene codes for
Definition
enzymes
Term
env gene codes for
Definition
spike proteins in envelope
Term
HIV matrix structure and location
Definition
p17, inside envelope
Term
hiv replication step where it becomes a provirus or "timebomb"
Definition
integration
Term
number of virions an HIV infected cell can produce in a day
Definition
5000
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