Term
| Which of the following polymorphic enzymes has the greatest effect on the activity of Plavix? |
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Definition
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Term
Which of the following is not a prodrug?
I. Clopidogrel
II. Parsugrel
III. Ticagrelor |
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Definition
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Term
| What factors should be considered when choosing drugs from the same class? |
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Definition
A. Metabolism
B. Duration of action
D. A and B |
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Term
| Why is amlodipine the preferred choice of CCB’s among physicians? |
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Definition
| A. Has less first pass metabolism |
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Term
| Lack of which enzyme can aggregate GI side effects such as diarrhea for the drug irinotecan? |
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Definition
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Term
| Which of these drug classes will precipitate hemolytic anemia in a G6PD patient? |
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Definition
A. Antimalarial
B. Sulfonamides
D. A and B |
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Term
Which of these choices is a drug induced adverse effect in patients with G6PD deficiency?
I. Hemolytic anemia
II. Liver toxicity
III. Colon Cancer |
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Definition
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Term
| It is known that hydrophilic statins are the most effective on organic anion transporters (OATs). All of the following are considered hydrophilic statins except |
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Definition
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Term
| We have a patient that was prescribed a low dose of warfarin. Describe the patients VKOR activity and their possible ethnicity |
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Definition
| C. Low VKOR activity; Asian |
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Term
| What makes Clopidogrel a poor drug choice for all populations compared to Parsugel and Ticagrelor? |
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Definition
| A. Clopidegrel can take two inactive metabolite pathways that are affected by metabolic profile. |
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Term
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Definition
Activation of carcinogens
Induced by smoking |
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Term
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Definition
Metabolizes procarcinogens, nicotine, naproxen
2% of Caucasian and 20% of Asian population are poor metabolizers |
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Term
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Definition
| Metabolizes non-nuleoside reverse transcriptase inhibitor (e.g. Efavirenz), cylcophosphamide, Bupropion ets |
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Term
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Definition
| Metabolizes tricyclic antidepressants, diazepam and verapamil |
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Term
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Definition
| Metabolizes warfarin, phenytoin, NSAIDs, fluoxetine etc |
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Term
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Definition
Metabolizes PPIs, TCAs, clopidogrel, antiepileptics etc
13-23% Asians and 2-6% Caucasians are PMs |
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Term
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Definition
Metabolizes 21% clinically important drugs
Drugs metabolized 2D6 are rarely metabolized by other CYP isoforms |
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