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Corticosteroids and Synthetic Analog Drugs
Drug and what they do
12
Medical
Graduate
11/06/2012

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Term
Fluticasone
Definition
used for allergic rhinitis. used as inhalant b/c it has poor bioavailability and fast metabolism.
Term
Beclomethasone Dipropionate
Definition
Used for inhalation therapy. Ideal b/c have poor bioavailability (systemically) and are rapidly metabolized (good if they get into general circulation)
Used to stimulate lung maturation of fetus in predicted premie. Treat 48 hours out and 24 hours out from delivery.
Term
Budesonide
Definition
Used for inhalation therapy (asthma). Ideal for inhalation due to poor bioavailability and high metabolism rate
Term
Hydrocortisone/cortisol
Definition
Short-acting. activated cortisone by 11B-HSD1. Used to treat Addisons and secondary adrenal deficiency. Addisons may require fludrocortisone for MC replacement. also used as a topical therapy for eczema, UC or crohns.
Term
Prednisolone
Definition
activated prednisone. Intermediate Acting. Used for systemic/oral treatment of inflammation (asthma, IBD)
Term
Methylprednisolone
Definition
used for immunosuppression (graft vs host)
Term
Triamcinolone
Definition
intermediate acting w/ no MC activity.
used for severe psoriasis.
Term
Beclomethasone
Definition
used for inhalation therapy in asthma
Term
Dexamethasone
Definition
Long-acting w/ no MC activity.
used to diagnose Cushings Syndrome. GC levels should show depression pts w/o cushings. Used for immunosuppression.
Term
Fludrocortisone
Definition
used to replace MCs.
Term
Mifepristone
Definition
GC antagonist
Term
Spironolactone
Definition
MC antagonist
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