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Step 3 Endocrinology
USMLE
47
Medical
Professional
11/10/2017

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Term
risk fx for stress hyperglycemia?
Definition
ICU admission, fever, severe illness, sepsis, CNS infxn.

Give Insulin
Term
Dx criteria for DM
Definition
A1c= 6.5%
Random BG= >200 OR Sx
Fasting BG= >126 x 2
Term
fatigue, wt loss, myalgias, incr'd pigmentation, and decr'd axillary/pubic hair.

How to confirm this dx?
Definition
Chronic Adrenal insufficiency

confirm with low morning plasma cortisol/ACTH
Term
decr TSH with other normal hormones

what to do if TSH persistently <0.1?
Definition
Subclinical thyrotoxicosis

consider meds or radio iodine
Term
causes of subclinical thyrotoxicosis?
Definition
exogenous hormones, Graves, nodular thyroid dz
Term
necrolytic migratroy erythema rash assoc?
Definition
Glucagonoma
Term
Thyrotoxicosis manifestations in Elderly?
Definition
Afib
apathy, confusion, prox musc wasting
proptosis and lid lag
decr appetite and constipation
Term
subclinical hypothyroidism assoc>
Definition
incr'd risk of recurrent miscarriages
severe preeclampsia
preterm labor, abruptio
Term
hyperthyroid complications
Definition
Arrhtyhmias, CM, Osteoporosis
Term
Major diff btw NPH and Glargine
Definition
Glargine has lesser risk of hypoglycemia
Term
tx for MEN/MTC tumors
Definition
thyroidectomy
Term
sequelae of Lithium on thyroid
Definition
HYPOthyroidism. Don't stop it, just add Levo
Term
Low Ca
Low Phos
High PTH
Definition
Vit D def
Term
low Ca
high phos
low pth
Definition
Hypo PTH
Term
low ca
high phos
high pth
Definition
Pseudo PTH or Hyper PO4
Term
Thyroid ca dx workup?
Definition
U/S of neck and cervical LN
- <1cm = Papillary Lobectomy
- >1cm = Total thyroidectomy
Term
in DKA, when do you consider decr Insulin infusion and add Dextros?
Definition
When Glucose <200 and AG still elevated

done to decr chance of hypoglycemia
Term
Sulfonylurea poisoning tx
Definition
Dextrose given first
Give Octreotide
Term
Insulin and early morning exercise
Definition
decr short acting insulin w/i 1-3 hrs prior

if it's really early, consider a change to basal insulin
Term
when to give bisphosphonate tx
Definition
Osteoporosis (T score <-2.5)
Osteopenia (T score -1 and -2.5) with 10 yr prob >20% major OR >3% hip frac
Term
HTN, hyperglycemia, osteoporosis, mood swings, low K
Definition
Cushing's syndrome
Term
how to dx pheo after pos blood studies
Definition
CT/MRI abdomen
pos= surgery, a/b blockers prior
neg= Oct scan, MIBG, PET
Term
These drugs increase TBG and decr T4 requiring incr in thyroid tx
Definition
Estrogen, Tamoxifen, Raloxifene, Methadone, heroin
Term
these drugs decr TBG and reducing Levo need
Definition
Steroids, Androgens, danazol
Term
these drugs decr Levo resorption
Definition
cholestyramine
Iron, Calcium, PPI, Carafate
Term
drugs that increase thyroid metabolism
Definition
Rifampin, phenytoin, carbamazepine
Term
Primary w/u in FTT pt
Definition
diet hx, analysis of psychosocial stressors
Term
hyperthyroid in pregn w/non tender Goiter
Definition
Post-partum thyroidism.

-consistent with TPO ab's

similar to Silent thyroidits also.
Term
Incr RAIU
Incr TBG
Definition
Graves
Term
decr RAIU
incr TG
Definition
Silent thy
PT
Dequiervan's
Term
Tender glad with hx of recent viral illness
Definition
Dequiervan's (subacute)
tx is NSAID and BB
Term
Exercised induced amenorrhea pathophys
Definition
decr LH --> decr Estrogen-->infertility, osteopenia
Term
Gestational DM w/u
Definition
24-28 wks
1. 50g Glu load
-<140 NO DM and no further testing
->140 100g 3hr
Term
Gestational DM target levels
Definition
Fasting <95
1 hr post prand <140
2 hr post prand <120
Term
Gestational DM tx
Definition
first line- diet
second line Insulin
Term
Suspected Hyperthyroid w/u (incr TSH and T3/4)
Definition
MRI for pituitary
Term
normal Hyper PTH w/u AND sx's of Graves
Definition
NO further workup needed
Term
normal hyper thy w/u
Definition
1. RAIU
-High nodular-->Adenoma/multi goiter
-High Diffuse--> Graves

-Low RAIU-->TBG
-High TBG- Thyroiditis/Iodine exposure
Term
Thyroid nodule workup
Definition
1. TSH/US
Cancer suspicion--> FNA
No ca suspicion-->Low TSH
-run I scitigraphy
-cold-->FNA
Term
Toxic adenoma tx
Definition
pre treat with Methimazole.

consider ablation or surgery
Term
hemochromatosis Endo issues
Definition
Hypogonadism and Infertility
Term
MCC of HyperPTH
Definition
adenoma
Term
abd pain (groans), bone pain, and psych overtone

-incr PTH with elevated urine Ca
Definition
Hyper PTH
Term
indications for a parathyroidectomy
Definition
Age <50
SYMPTOMATIC hyper Ca
Urinary Ca >4k a day
Term
Amiodarone effect on Thyroid
Definition
decr peripheral conversion of T4-->3
borderline incr TSH, INCR T4 and low T3

abnx will go away in 3-6 mos.
Term
nml TSH, T4, and LOW T3

what causes this?
Definition
Euthyroid sick syndrome

cortisol, TNF, starvation, GC's Amiodarone
Term
DKA/HHS mgmt
Definition
IVF, Insulin, Potassium

IVF--> high flow NS; add D5 when <200
Insulin--> IV infusion decrease when able to eat Glu <200, AG <12 and HCO3 >15
Potassium--> add IV if <5.2meq/Hold Insulin <3.3
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