Term
Cyclosporine
mechanism
use
toxicity |
|
Definition
binds to cyclophilins which allows it to inhibit calcineurin and prevent production of IL-2 and its receptor.
transplants, autoimmune disease
increased viral infections and lymphoma, NEPHROTOXIC (mannitol diuresis), gout |
|
|
Term
Tacrolimus
mechanism
use
toxicity |
|
Definition
Binds to FK-binding protein inhibiting secretion of IL-2 and other cytokines
Transplants
NEPHROTOXICITY, neuropathy, HTN, pleural effusions, hyperglycemia |
|
|
Term
Sirolimus
mechanism
use
toxicity |
|
Definition
Inhibits mTOR thus inhibiting T cell proliferation in response to IL-2
Transplants (kidney), drug-eluting stents
Hyperlipidemia, thrombocytopenia, leukopenia |
|
|
Term
|
Definition
| anti-IL2 receptor antibody |
|
|
Term
Azathioprine
mechanism
use
toxicity |
|
Definition
6-MP precursor that interferes with metabolism and synthesis of nucleic acids thus toxic to proliferating leukocytes
Transplants (kidney) autoimmunity
Bone marrow suppression, toxic with allopurinol |
|
|
Term
|
Definition
anti-CD3 antibody
transplants (kidney)
cytokine release syndrome, hypersensitivity |
|
|
Term
|
Definition
IL-2 analog
Renal cell carcinoma, metastatic melanoma |
|
|
Term
Erythropoietin
mechanism
use |
|
Definition
EPO analog
Anemia (renal failure) |
|
|
Term
|
Definition
GCSF analog
bone marrow recovery |
|
|
Term
|
Definition
GM-CSF analog
Bone marrow recovery |
|
|
Term
|
Definition
HBV, HCV
Kaposi's
Leukemia
Malignant melanoma |
|
|
Term
|
Definition
|
|
Term
|
Definition
| chronic granulomatous disease |
|
|
Term
|
Definition
IL-11 analog
Thrombocytopenia |
|
|
Term
|
Definition
|
|
Term
|
Definition
anti-TNFa antibody
Crohn's, RA, psoriatic arthritis, ankylosing spondy |
|
|
Term
|
Definition
anti-TNFa antibody
Crohn's, RA, psoriatic arthritis |
|
|
Term
|
Definition
Anti-glycoprotein 2b/3a antibody
prevent cardiac ischemia in unstable angina or post percutaneous cardiac intervention |
|
|
Term
|
Definition
anti erb-B2 antibody
HER-2 over expressing breast cancer |
|
|
Term
|
Definition
anti CD20 antibody
B cell non-Hodgkin's lymphoma |
|
|
Term
|
Definition
anti IgE antibody
Severe asthma |
|
|
