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Stem Cell Therapy
Lecture 10/3
18
Medical
Professional
10/06/2013

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Cards

Term
What is the primary limitation to giving larger doses of chemotherapry?
Definition
Bone marrow toxicity
Term
Which drugs in particular have steep dose responses?
Definition
Alkylating agents
Term
What is the goal of Hematopoietic Stem Cell transplant?
Definition
Engraph bone marrow stem cells to help regenerate bone marrow
Term
What is the ideal transplant for treatment of an aggressive tumor?
Definition
Allogenic
Term
Autologous transplant uses patient's own stem cells and is most effective at treating what tumors?
Definition
Chemosensitive tumors
Term
What is the determinant marker for hematopoietic stem cells?
Definition
CD34
Term
How are stem cells acquired for autologous transplant (from what tissue)
Definition
Peripheral blood
Term
28
Definition
28
Term
What is the benefit of Synergeneic transplant vs autologous?
Definition
There are no contaminating tumor cells collected in the samples and given to the patient
Term
What is the disadvantage of synergeneic transplant vs autologous?
Definition
There is no immunologic attack on the tumor cells
Term
What are the advantages of HLA-matched Allogeneic transplant?
Definition
No malignant cells collected AND there is a chance for graft vs malignancy effect
Term
What is the main disadvantage of Allogeneic transplants?
Definition
Hard to find a proper donor
Term
Any transfusions given to immunosuppressed patients should undergo what process first?
Definition
irradiation to kill off leukocytes
Term
What are the three target organs for Acute GVHD?
Definition
Skin, Gut, Liver
Term
What population is Nonmyeloablative (reduced-intensity) transplant most useful for?
Definition
The elderly, who are less likely to tolerate high dose chemotherapy
Term
What four conditions normally cause elevation of PT but normal PTT?
Definition
1) Vit. K deficiency, 2) Warfarin therapy, 3) Liver disease, 4) Factor VII deficiency
Term
What factors may be affected if there is a normal PT but prolonged PTT?
Definition
Factors VIII, IX, XI, XII
Term
Treatment for TTP
Definition
Plasma Exchange
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