Term
| NucleoSide Reverse Transcriptase Inhibitors (NRTIs) |
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Definition
zidovidine (Retrovir);
didanosine (Videx);
stavudine (Zerit);
lamivudine (Epivir);
abacavir (Ziagen); |
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Term
| NucleoTide Reverse Transcriptase Inhibitor |
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Definition
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Term
| Non-NucleoSide Reverse Trascriptase Inhibitors (NNRTIs) |
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Definition
nevirapine (Viramune);
efavirenz (Sustiva); |
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Term
| Protease Inhibitors (PIs) |
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Definition
saquinavir (Invirase, Fortovase);
ritonavir (Novir);
indinavir sulfate (Crixivan);
nelfinavir mesylate (Viracept); |
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Term
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Definition
NRTI; - pyrimidine nucleoSide;
MoA: viral reverse transcriptase inhibitor;
Good CSF penetration, 36% protein bound;
Excreted via kidneys;
Toxicities:
- bone marrow toxicity;
- GI intolerance - N/V, diarrhea, hepatitis;
- CNS - HA;
Used alone started at 14-34 wks of gestation & continued in infant for 1st 6 wks of life, reduced HIV transmission from 26% to 8%; |
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Term
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Definition
NRTI; - purine nucleoSide;
MoA: viral reverse transcriptase inhibitor;
Toxicities:
- peripheral neuropathy;
- pancreatitis;
- GI intolerance; |
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Term
|
Definition
NRTI; - pyrimidine nucleoSide;
MoA: viral reverse transcriptase inhibitor;
Toxicties:
- peripheral neuropathy;
- lactic acidosis; |
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Term
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Definition
NRTI; - pyrimidine nucleoSide;
MoA: viral reverse transcriptase inhibitor;
Indications:
- HIV & HEPATITIS B;
Toxicity:
- minimal toxicity, nasal congestion;
- nausea, malaise, fatigue;
- flare of HEPATITIS B; |
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Term
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Definition
NRTI; - nucleoSide ANALOGUE;
MoA: viral reverse transcriptase inhibitor;
Toxicity:
- SEVERE HYPERSENSITIVITY rxn; |
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Term
|
Definition
NNRTI; - nucleoTide;
MoA: viral reverse transcriptase inhibitor;
Toxicities:
- GI disturbances - N/V, diarrhea;
- renal toxicity; |
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Term
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Definition
NNRTI; - non-nucleoside;
MoA: viral reverse transcriptase inhibitor, P450 metabolism;
Toxicitiy:
- hepatotoxicity;
- fever, nausea, HA;
- rash; |
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Term
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Definition
NNRTI; - non-nucleoside;
MoA: viral reverse transcriptase inhibitor, P450 metabolism;
Toxicities:
- rash;
- dizziness, HA, insomnia;
- neural tube defects; |
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Term
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Definition
PI; modified peptide;
MoA: viral protease inhibition, P450 metabolism;
Toxicities:
- GI disturbance;
- abnormal fat distribution;
- aminotransferases increase; |
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Term
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Definition
PI; modified peptide;
MoA: viral protease inhibitor, P450 metabolism;
Toxicities:
- GI disturbance;
- circumoral & peripheral paresthesia;
- aminotransferase increase; |
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Term
|
Definition
PI; modified peptide;
MoA: viral protease inhibition, P450 metabolism;
Toxicities:
- GI disturbance;
- nephrolithiasis;
- hyperbilirubinemia;
- dermatological changes; |
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Term
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Definition
PI; synthetic non-peptide;
MoA: viral protease inhibitor, P450 metabolism;
Toxicities:
- GI disturbance |
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