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Spleen, Retroperitoneum, Adrenal Gland, Peritoneum
Review of pathologies and sonographic details
105
Pathology
Undergraduate 2
11/27/2010

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Term
abdominal pelvic abscess
Definition
localized collection of pus; variable shape; near surgery sites; gas/ reverb artifact
Term
asplenia
Definition
female; bilateral rightsidedness; reversed AO/IVC; horseshoe kidney; absent spleen
Term
polysplenia
Definition
male; bilateral leftsidedness; multiple spleens
Term
situs solitus
Definition
a normal arrangement of asymmetric body parts
Term
situs inversus
Definition
mirror image condition
Term
situs ambiguous
Definition
wide spectrum of abnormalities between 2 extremes
Term
accessory spleens (splenunculi)
Definition
30% of autopsies; common normal variant; near hilum; may torse; may confuse with LN or masses
Term
splenic trauma
Definition
caused by blunt injury; symptoms: hypovolemic shock or LUQ pain;more common in children; assoc w/ pleural effusion; 24-48 hrs looks like normal spleen
Term
subcapsular hematoma
Definition
crescent shaped; capsule remains intact
Term
pericapsular hematoma
Definition
ruptured capsule; irregular shape
Term
candidiasis
Definition
wheel in a wheel; multiple nodules in immunocompromised pts.; bulls eye
Term
schistosomiasis
Definition
splenomegaly;focal hyperechoic nodules
Term
Gaucher's disease
Definition
splenomegaly;well defined hypoechoic (usu) nodules; familial disorder of fat metabolism; 50% < 8 yr old
Term
splenic infarction
Definition
caused by occlusion od splenic artery or its brances; peripheral wedge shaped hyp- lesion; assoc w/ bacterial endocarditis and splenic artery aneurysms
Term
splenic abscess
Definition
may appear as simple cyst but will have fever, abd pain, LUQ pain, leukocytosis; assoc w/ generalized sepsis; ill defined irreg. borders
Term
hemangioma
Definition
most common benign primary neoplasm of the spleen;males 20-50 yr; assoc. w/ Klippel-Trenaunay-Weber
Term
Klippel-Trenaunay-Weber Syndrome
Definition
hypertrophy of bones and tissue; affects one extremity; skin varices
Term
posttraumatic cysts (pseudocysts)
Definition
no cellular lining; may have calc. walls; low level echoes (cholesterol crystals/debris)
Term
pancreatic pseudocysts
Definition
due to pancreatitis; pancreatitis symptoms; possible pseudoaneurysms
Term
METS to spleen
Definition
sites are usually melanoma, breast, lung, lymphoma, leukemia; usu. hypoechoic but variable
Term
primary malignancy of spleen
Definition
rare; two types are lymphoma and angiosarcoma
Term
infectious cysts
Definition
may be caused by echinococcus; dx by serologic tests and geographic background; "eggshell calcification"; fever, LUQ pain, incr. WBCs
Term
splenomegaly
Definition
"eyeball" technique; >12 cm; may have palp mass; L. kid displaced inf.
Term
Mild to Moderate splenomegaly
Definition
infection, portal htn, AIDS
Term
Marked splenomegaly
Definition
leukemia, lymphoma, mononucleosis
Term
massive splenomegaly
Definition
myelofibrosis (replacement of bone marrow with fibrous tissue)
Term
polycythemia vera
Definition
another cause of splenomegaly due to over production of blood cells
Term
adrenal cysts
Definition
3:1 female; 3rd to 5th decade; 4 types are endothelial, epithelial, pseudocyst, parasitic
Term
Cushing's Disease
Definition
excessive cortisol secretion due to increased ACTH production from a pituitary adenoma
Term
Lymphocele (retroperitoneal)
Definition
fluid collection containing lymph;assoc w/ renal transplant; occurs 10-21 days after surgery
Term
retroperitoneal abscess
Definition
abd pain, fever, palp mass; complex, thick wall, variable appearance
Term
urinoma
Definition
walled off collection of extravasated urine; caused by trauma, surgery or chronic urinary obstruction
Term
retroperitoneal hemorrhage
Definition
caused by trauma, bleeding, leaking AAA or post surg.; common sites are psoas muscle and perinephric space
Term
retroperitoneal fibrosis (Ormond's Disease)
Definition
2-6 cm thick fibrous tissue; looks like plaque around distal AO; assoc w, bilateral ureteral obstruction
Term
Retroperitoneal METS
Definition
spread is lymphatic or hematogenous, or by direct extension; most common METS from testicles and pelvis
Term
lymphadenopathy
Definition
enlarged LN; malignant are round or oval w/ cortical widening; narrowed or absent echogenic hilum; floating AO sign
Term
adrenal hemorrhage
Definition
25% of severely injured pts.; common in neonates
Term
Conn's Disease
Definition
increased secretion of aldosterone; 70% from adrenal adenoma; htn, muscle weakness, abn ECG
Term
hyperfunctional adrenal cortical carcinoma
Definition
more common in females; small, homogenous, similar to renal echogenic cortex
Term
nonfunctional adrenal cortical carcinoma
Definition
more common in males; large, hetero w/ necr, hemorr, calc
Term
adrenal cortical carcinoma
Definition
rare; 4th decade; poor px; invasion of adrenal vein, IVC, and lymph glands
Term
adrenal myelolipoma
Definition
benign fatty mass; hyperechoic
Term
adrenal METS
Definition
4th most common site for METS
Term
transudative
Definition
anechoic fluid; free floating bowel; conforms to strux; thick GB wall; decreased albumin and cell count; clear
Term
exudative fluid
Definition
septations, echogenic debris, loculations; matted bowel loops; does not conform to strux;increased albumin and cell count; cloudy
Term
FAST
Definition
usually takes place in ER; focused assessment w/ sonography for trauma
Term
particulate ascites
Definition
presence of blood, pus, or neplastic cells in the fluid
Term
adrenal adenoma
Definition
made of glandular epithelium; increased incidence with age; 10% bilateral; majority are nonfunctioning
Term
hemoperitoneum
Definition
effusion of blood into peritoneal cavity; caused by trauma, ruptured ectopic preg; large echogenic mass, hetero over time
Term
pheochromocytoma
Definition
excess secretion of epinephrine and NE; 2nd-5th decades; more common on right; assoc w/ von Hippel-Lindau;palpitations, perspiration,intermittent htn, headaches
Term
chylous ascites
Definition
lymph collection in peritoneal cavity; fluid-fluid level
Term
chylous ascites
Definition
lymph collection in peritoneal cavity; fluid-fluid level
Term
pseudomyxoma peritonei
Definition
rare; often fatal; gelatinous ascites; bowel appear as "starburst"
Term
primary congenital cysts
Definition
no clinical significance; have epithelial or endothelial lining; arise from meso cells in spleen; avg size 10cm; types are lymphangiomas or cystic hemangiomas
Term
primary retroperitoneal tumors
Definition
men 3:1; 70-90% malignant; 22-50% survival after 5 yrs
Term
What produces hCG?
Definition
trophoblastic tissue
Term
What class of organic molecules is hCG?
Definition
glycoprotein
Term
What does hCG support the growth of?
Definition
the corpus luteum
Term
Where can the presence of hCG be detected?
Definition
maternal serum(in blood) and urine
Term
In relation to LMP, when may hCG be first detected?
Definition
3 weeks after 1st day of LMP (day 21)
Term
When may hCG be detected in relation to ovulation?
Definition
7-10 days after ovulation (day 21-24)
Term
How often does the hCG level double?
Definition
every 2-3 days
Term
At about how many weeks does the level of hCG plateau in its production?
Definition
8-9 weeks
Term
Testing the urine produces what type of analysis of hCG?
Definition
qualitative; positive or negative only NOT amount
Term
What type of analysis of hCG is possible with serum detection (Beta hCG)?
Definition
quantitative;specific levels present in blood
Term
If hCG level is high for given dates, what might be suspected?
Definition
incorrect dates(LMP), multiples, GTD or GTN (Gestational Trophoblastic Disease/Neoplasia)
Term
If hCG is low for what is expected, what is suspected?
Definition
incorrect LMP, ectopic pregnancy, embryonic demise
Term
What are the three standards recognized for evaluating hCG levels?
Definition
SIS, FIRP, and TIS
Term
What does SIS stand for?
Definition
Second International Standard
Term
What does FIRP stand for?
Definition
WHO's First International Reference Preparation
Term
What does TIS stand for?
Definition
Third International Standard
Term
How do you convert from SIS to FIRP/TIS?
Definition
beta hCG (FIRP/TIS)/ beta hCG (SIS)=2 OR
"double SIS to get FIRP/TIS"
Term
Where in the uterus does implantation usually occur?
Definition
fundus of uterus
Term
What is the gestational sac?
Definition
a fluid filled chorionic sac
Term
What is the first fundamental ultra sound finding of early pregnancy?
Definition
gestational sac
Term
What is the "intradecidual sign"?
Definition
small GS within the thickened decidua
Term
What is the earliest consistent demonstration of the intradecidual sign?
Definition
about 3.5 weeks
Term
What is the General Rule for when we are able to identifying the GS?
Definition
4.5-5 weeks TV/TA
Term
What is the threshold level?
Definition
(4wk 3d)the earliest we expect to see the GS
Term
What is the discriminatory level?
Definition
5wk 2d SHOULD always see GS
Term
What 3 indications mean we will ALWAYS see a GS?
Definition
1) Serum beta hCG>800-1,000 mIUml TIS endo vag

2)Serum beta hCG>3600 mIUml (TIS) TA

3) Certain LMP> 5 weeks with a normal 28 day cycle
Term
What serum level of hCG is the TIS beta hCG when we should see the GS endovaginally?
Definition
800-1000 mIUml (400-500 SIS)
Term
What serum level of hCG is the TIS beta hCG when we should see the GS transabdominally?
Definition
3600 mIUml (1800 SIS)
Term
What "sign" is associated with the normal GS?
Definition
"double sac sign" (two echogenic rings)
Term
What is the shape of the GS?
Definition
round and then turns oval as it enlarges
Term
Describe the borders of the GS?
Definition
echogenic well-defined/intact borders
Term
What is the GS filled with?
Definition
extracoelomic or chorionic sac fluid
Term
Compare amniotic fluid and chorionic fluid.
Definition
chorionic fluid is more echogenic than aniotic fluid due to high protein content
Term
Where should the GS be located in a normal pregnancy?
Definition
high (fundus) to mid uterine
Term
In the double sac sign what are the two echogenic lines we see?
Definition
Decidua capsularis (inner ring closest to GS) Decidua parietalis (outer ring)
Term
What lies between the two echogenic rings in the double decidual sign?
Definition
the hypoechoic/anechoic uterine cavity
Term
What are GS criteria for dx of an early pregnancy failure (if seen together or with an abnormally large GS)?
Definition
1) distorted GS shape 2)thin trophoblastic reaction (<2mm) DC 3) weakly echogenic trophoblast DC 4) abnormally low position of GS
Term
What measurement is used prior to getting a CRL or up to 6 weeks?
Definition
MSD -mean sac diameter
Term
How accurate is the MSD measurement?
Definition
within one week of GA
Term
How much does the GS grow daily?
Definition
1.1 mm per day
Term
Which is more accurate in measuring MSD? TA or TV exams?
Definition
TV or endovaginal
Term
Where is the sac diameter measured?
Definition
in three planes @ fluid-tissue interface or "inner-to-inner"
Term
What is the formula for calculating MSD?
Definition
MSD in mm=(AP+long+trans)/3
Term
Using MSD, how can you calculate MA?
Definition
MSD in mm +30 days= MA in days
Term
What is the % that miscarry with a smaller than expected MSD?
Definition
93%
Term
At what MSD should the YS (yolk sac) be present?
Definition
8 mm
Term
At what MSD should an embryo be present?
Definition
16mm
Term
After how many days should the patient be re-examined if the MSD and associated structures aren't present?
Definition
3-4 days to give benefit of the doubt
Term
What is the primary YS and do we see it sonographically?
Definition
it is the first site of formation of RBC (red blood cells) that will nourish the embryo and NO we can't see it with US
Term
When a sonographer visualizes or speaks of a yolk sac which yolk sac is being seen?
Definition
secondary yolk sac
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