Term
What is the order of rearrangement in B cell receptors?
What rearranges first in alpha-beta T cell receptors? |
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Definition
DJ (heavy chain) then VDJ (involves DNA, most are deletions)
Beta chain |
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Term
| What are the trafficking signals for naive T cells to lymph nodes, and peyers patches? |
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Definition
L-selectin:GlyCAM
Alpha4beta7:MadCAM1 |
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Term
What is the function of selectin and integrin? What upregulates both?
What cause neutrophils to follow? |
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Definition
Selectin - on vessel slows down neutrophil
Integrin - on neutrophil allows integration into tissue
IL-1 and TNF
f-met and C5a |
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Term
What is the T cell co-receptor and co-stimulatory signal for activation of naive T cells?
What competes with this co-stimulator? |
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Definition
CD28 on T cell:B7-1(CD80) or B7-2(CD86) on APC
CTLA-4 competes with CD28 for B7 and down regulates |
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Term
| Which nonclassical MHC binds lipids instead of proteins and which cells does it present to? |
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Definition
| CD1 presents to T (gamma-delta) and NKT cells |
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Term
| What receptor helps T cells exit the lymph node? What keeps effector T cells in the lymph node initially? |
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Definition
S1PR1 on T cells binds to S1P in the blood
CD69 blocks S1PR1 on effector T cells to stay in the lymph node to clonally expand |
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Term
What chemokine receptors attract T cells to the T zone of lymph nodes, attract B cells to the follicle of the lymph node?
Which two chemokine receptors are coreceptors for HIV? |
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Definition
CCR7
CXCR5
CCR5 and CXCR4 |
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Term
| What complements make up the MAC? |
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Definition
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Term
What is the order of Ig molecules on the gene segment of chromosome 14?
What is the order of IgG subclasses?
Which IgG subclass has the shortest half life? |
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Definition
IgM or IgD then IgG, IgE and IgA
IgG3, IgG1 and IgG2
IgG3 |
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Term
What cytokines cause class switching from IgM to IgE, IgG subclasses and IgA?
Class switching changes which region on the antibody? |
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Definition
IL-4 and IL-13
IFN-gamma
TGF-beta and IL-5
C region |
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Term
What are the Th1 cytokines and what do they do?
What are the Th2 cytokines and what do they do?
What are the Th17 cytokines and what do they do? |
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Definition
IFN-gamma (macrophage activation, class switching to IgG3), IL-2 (CTL and NK cell activation), TNF (primes macrophages and NK cells)
IL-4 (class switching to IgE), IL-5 (eosinophil activation, class switching to IgA) and IL-13 (decrease proliferation of Th1 cells)
IL-17 (neutrophil activation) and IL-22 |
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Term
| What two types of antibodies activate the complement system via the classical pathway? |
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Definition
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Term
What antibody has the highest plasma concentration?
Highest total body concentration? |
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Definition
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Term
| What changes antibodies from transmembrane to secretory form and also produces IgD? |
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Definition
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