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| Chickenpox (Herpes virus) |
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| much virus in the bloodstream |
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genome (double-stranded DNA)
capsid & envelope
big (300 nm) |
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humans
cattle
goats
monkeys
elephants
camels
mice
(Smallpox is species-specific, but some cross-species infection occurs) |
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Humans: Smallpox; molluscum contagiosum
Animals: Orf (sheep, goats); Cowpox (cattle); Monkeypox (monkeys) |
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droplet inhalation
scab contact |
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| Smallpox becomes contagious within... |
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3-4 days/halfway through incubation period
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| first Smallpox symptoms (3-4 days) |
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| Smallpox symptoms (10-12 days) |
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1.) rash>
macule formation>pepule>vesicle>
pustule>crusted>scar
high fever (44 C/107 F)
malaise
delirium |
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| Smallpox (if survived) heals... |
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very slowly
(Smallpox makes one highly susceptible to secondary bacteria infections) |
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lifestyle change (hunter/gatherer>agricultural)
Asia/Africa 10000 BCE
zoonosis |
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| early clinical evidence of Smallpox |
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Egyptian mummies 1570-1085 BCE
(Ramses V - died 115 BCE)
China 200 AD
Korea 583 AD
Japan 585 AD |
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| first major Smallpox plague |
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Plague of Antonius 100 AD
15 years
Mesopotamia>soldiers>Rome
(note: death of Marcus Arelius) |
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12th & 13th centuries
courtesy traders & crusaders
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| major Smallpox epidemics in Europe |
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England & Germany 1300s
Scandanavia 1500s
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| first record of Smallpox in the Americas |
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1518 Hisponiola (slave trade from west Africa)
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| Smallpox's role in invasions of Conquistadors |
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Cortez (Mexico/Aztecs) 1521
Fransisco Pizarro (S. America/Incas) 1532
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| Smallpox occurrences in Colonial America |
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Colonists 1617 (English settlers) Jamestown
English Pilgrims 1620 (Plymouth/Province Town) |
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| Smallpox in French & Indian War (year) |
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| Smallpox victims in history |
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Queen Elizabeth I
Wolfgang Amadeus Mozart
Ludwig von Beethoven
Tsar Peter III
Pocohontas
George Washington
Abraham Lincoln
Joseph Stalin |
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| Early treatments for Smallpox |
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1314
alleged fire, red clothes, red drink, red food could treat Smallpox |
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1834
alleged red light could treat Smallpox |
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intentional inoculation using Smallpox scabs
2 % death rate
lifelong immunity
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