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Small Lab Animals
Mice, Rats, Gerbils, Hamsters, Guinea Pigs, and Rabbits
110
Veterinary Medicine
Undergraduate 1
05/04/2015

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Cards

Term
Muridae
Definition
Family mice belong to.
Term
Rodentia
Definition
Order mice belong to.
Term
Mammalia
Definition
Class mice are associated with?
Term
Mice have a ____ litter size.
Definition
Large
Term
Lifespan of mice
Definition
2-3 years
Term
Outbred Strains
Definition
Random breeding, large quantities of unrelated litters.
Term
Inbred Strains
Definition
breeding of relatives, 20 generations of bother/sister matings = isogenic mouse
Term
C57BL
Definition
Black
Term
Balb/c
Definition
Albino
Term
C3H
Definition
Agouti
Term
DBA
Definition
Brown
Term
F1 hybrid
Definition
the offspring of 2 different inbred strains.
Term
Hybrid vigor
Definition
heartier
Term
cogenic
Definition
a mouse/mice bred genetically different
Term
transgenic
Definition
(knockout mice) DNA introduced to the developing eggs; genes can be taken away. Ability to alter genetic makeup
Term
recombinant
Definition
molecular cloning to make a new DNA sequence; combining genetic material
Term
Identification methods
Definition
Ear notching, ear punching, ear or tail tattooing, microchip, cage cards, or temporary id(fur dye)
Term
Average weight of mice
Definition
20-40grams
Term
T/F: Mice are born naked, blind, and deaf
Definition
True
Term
The weaning age for mice is...
Definition
3-4 weeks
Term
500/minute for a mouse is...
Definition
Heart rate
Term
140/minute for a mouse is...
Definition
Respiratory rate
Term
96.9-100F
Definition
The average temperature of a mouse
Term
T/F: The 2 prominent incisors grow continuously and are worn down by friction
Definition
True
Term
A female has __ visible teats.
Definition
6
Term
Which strain is without hair but also immune deficient?
Definition
Nude mice (nu/nu)
Term
nu/nu
Definition
Nude
Term
Mice reach puberty at ___ weeks.
Definition
6-8
Term
Mice have hair at ___ days.
Definition
7-10
Term
Mice pups eyes open at ___ days.
Definition
12-13
Term
postpartum estrus
Definition
animals coming into heat and can be bred within 14-28 hours after giving birth, if bred, implantation is delayed until after lactation. (Mice, gerbils, guinea pigs, and rats)
Term
Bruce Effect
Definition
a pregnant mouse that is exposed to the presence of a strange mouse within 4 days of breeding will abort the pregnancy.
Term
Whitten Effect
Definition
the result of large groups of female mice housed together in which the females will go into an-estrus; if male is introduced, cycles will begin again.
Term
An-estrus
Definition
To go without an estrus cycle
Term
Lee-Boot Effect
Definition
females housed together in large groups can initiate pseudo-pregnancy in some
Term
Parturition
Definition
Giving birth
Term
Spontaneous ovulation
Definition
ovulation occurs at the time of copulation
Term
Poly-estrus
Definition
many heat cycles; as soon as one ends another begins.
Term
Estrus
Definition
the stage in the estrous cycle when the female is receptive to the male and will allow mating. (In heat)
Term
Estrous
Definition
from one heat cycle to the next, the reproductive cycle in animals
Term
Polygamous
Definition
harem colony (one male/several females)
Term
Monogamous
Definition
one breeding pair
Term
Isogenic
Definition
20 consecutive generations of brother/sister matings genetically HOMOZYGOUS
Term
Germ-free or Axenic
Definition
animals derived from hysterectomy, free from any micro organisms; lacks normal flora as well.
Term
Gnotobiotic
Definition
germ-free mice that have been introduced to on or two known non-pathogenic microorganisms, defined flora.
Term
Specific Pathogen Free (SPF)
Definition
free from specific pathogenic organisms
Term
Barrier-Sustained
Definition
maintained under sterile conditions in a barrier unit
Term
Conventional
Definition
animals bred with no special precautions and possess unknown and various microorganisms.
Term
The sex of a rat is determined by:
Definition
anogenital distance
Term
The genus and species name for the Mongolian Gerbil is:
Definition
Meriones unguiculatus
Term
A condition caused by low humanity is:
Definition
Ring-tail
Term
The average weight of an adult female hamster is:
Definition
100grams
Term
Which statement is true about epileptiform seizures?
Definition
They do not require treatment
Term
The average weight of an adult male rat is:
Definition
600grams
Term
Chromodacryorrhea means:
Definition
runny eyes
Term
Hibernation among hamsters is caused by:
Definition
lower ambient temperatures
Term
The average gestation period for the rat is:
Definition
21 days
Term
The average gestation period for a hamster is:
Definition
15 days
Term
The animal most likely to get infected cheek pouches is the:
Definition
Hamster
Term
The average life span of the rate is:
Definition
1-3 years
Term
A condition in the rat that is characterized by a pronounced head tilt is:
Definition
labyrinthitis
Term
The estrous cycle length in the rat is:
Definition
5 days
Term
Viral pneumonia in hamsters:
Definition
causes flu-like symptoms, lasts 5-7 days, and can be transmitted to humans
Term
the causative agent that can cause arthritis in rats as well as transmit rate bite fever to humans is:
Definition
Streptobacillus moniliformis
Term
Ring-tail is caused by:
Definition
low ambient humidity levels
Term
the correct genus and species of the hamster is:
Definition
Mesocricetus auratus
Term
A strain of rat that is used commonly in research:
Definition
Sprague-Dawley
Term
Breeding in hamsters can be difficult because
Definition
females often do not like their mates
Term
An animal having a sebaceous gland located on the abdominal mid-line is:
Definition
the gerbil
Term
The most common breed of hamster used in research is the:
Definition
Syrian
Term
Rats are:
Definition
primarily nocturnal, unable to vomit, and get along well with each other.
Term
The average weight of an adult gerbil is:
Definition
80-100grams
Term
A common disease found in hamsters who escape their "home" environment:
Definition
Wet tail
Term
The only rodent that diabetes is found in is:
Definition
the hamster
Term
Rats:
Definition
Make good pets, can be housed in pairs or singly, and have a weaning age of 3 weeks
Term
In which of the species below is the average female bigger than the average male?
Definition
hamsters
Term
Malocclusion is:
Definition
overgrowth of incisors
Term
Which lab animal below is commonly used for neurology studies?
Definition
the gerbil
Term
A condition in gerbils that can occur because of their burrowing habits is:
Definition
Muzzle Alopecia
Term
The strain of rat that is called a hooded rat is:
Definition
Long-Evans
Term
In the gerbil, a degloving injury during housing involves:
Definition
the tail
Term
Campylobactor jejuni is an bacteria that causes _____ in the hamster:
Definition
diarrhea
Term
To attract attention or express agitation,gerbils:
Definition
thump their hind limbs
Term
When hamsters are asleep:
Definition
do not disturb them, handle with care, and/or let sleeping hamsters lie.
Term
Hamsters:
Definition
Weigh: 85-130g(M) / 95-150g(F)
Body temperature: 98.6-100.4F
Lifespan: 18-24mo Heart-rate: 250-500
Respiratory rate: 35-135 BPM
Estrus: 4d postpartum estrus: no
litter: 5-9 gestation:59-72d
Term
Guinea Pigs:
Definition
Weigh: 900-1200g(M)/700-900g(F)
Body Temperature:99-103.1F
Lifespan:4-5y Heart-rate:230-380
Respiratory: 42-104 estrus: 15-17d
gestation:59-72d postpartum estrus: yes
litter: 2-5 wean:14-21d
Term
Gerbils:
Definition
Weigh: 65-100g(M)/55-85g(F)
Body Temperature:98.6-101.3F
Lifespan: 3-5 y Heart-rate:360 Respiratory:70-120 Estrus: 4-6d
gestation:15-16d postpartum estrus: yes
litter: 3-7 wean:20-30d
Term
Mice:
Definition
Weigh:20-40g(M)/25-40g(F)
Body Temperature:97.5-100.4F
Lifespan:1.3-3y Heart-rate:325-780
Respiratory:60-220 estrus: 4-5d
postpartum estrus: yes litter:6-12
wean:21-28d
Term
Rats:
Definition
Weigh:300-520g(M)/250-300g(F)
Body Temperature:96.6-99.5F
Lifespan:2.5-3.5y Heart-rate:250-450
Respiratory:70-115 estrus:4-10d
gestation:21-23d litter:6-12
Term
Barbering:
Definition
Hair chewing of the vibrisse or head region. Usually the one without hair loss is the "barber" and should be removed from the group.

Females 1.5 more likely. Increases during pregnancy.

Not a dominant behavior.
Term
Pinworms:
Definition
Syphacia obvelata and Aspicularis tetraptera inhabit the cecum and colon.

Associated with poor hair coat, mucoid enteritis, and anal pruritis, rectal prolapse, and intestinal impaction or intussuspection.

Fecal Examination
Treatment: Ivermectin, piperazine citrate, thiabendadozle, and mebendazole.
Term
Lice:
Definition
Polyplax serrata; blood sucking louse that causes skin irritation, anemia, and debilitation.

Treatment; Ivermectin and permethrin and malathion dust
Term
Tapeworms:
Definition
Rodentolepis nana, rodentolepis diminuta.

Both can transmit to humans.

Treatments: thiabendadozle or praziquantel
Term
Flagellates:
Definition
Spironucleus muris and giardia muris occur in small intestines and cecum.

Treatments: For giardiasis: metronidazole or oxytetracycline. None for the other.
Term
Mites:
Definition
Very common in mice colonies.
Term
Tyzzer's Disease:
Definition
Mice, rats, hamsters, gerbils, guinea pigs, dogs, cats, several nonhuman primates, and other animals are susceptible to this disease.

Long, thin, Gram-negative spore-forming bacterium.

Clinical signs: diarrhea, dehydration, and anorexia.

Treatment: tetracycline in drinking water for 4-5 days at high levels.

(StreptococcusBacterial Disease)
Term
Malocclusion:
Definition
Overgrowth of the incisors can occur when the jaw is maloccluded, there are missing teeth, or the diet is too soft.
Term
Parvoviruses:
Definition
Small and unenveloped DNA viruses; thus they are resistant to heat, lipid solvents, and acidic environments and can persist in the environment for months to years.
Term
Staphylococcus aureus:
Definition
is a Gram-positive cocci that commonly infects the skin and mucous membranes of animals.

Found om the skin and in the nasopharynx ans gastrointestinal tract.

Can be caused by bite wounds and is more troublesome with the nude mice.

(Bacterial Disease)
Term
Streptococcus spp:
Definition
Associated with dermatitis, pharyngitis, cervical lymphadenities, bacteremia, and a variety of other disease processes.

Immunodeficient mice are more susceptible to infection.

Systemic antibiotics and improved sanitation may be beneficial in treatment.
Term
Pneumonia
Definition
Naturally infects mice, rats, guinea pigs, hamsters, and probably other rodents.

Infections are asymptomatic, but they may cause dyspnea, listlessness, and a wasting disease in immunodeficient mice.
Term
Albino rat breeds include:
Definition
Sprague-Dawley and Wistar
Term
Most common outbred rats used in laboratories:
Definition
Sprague-Dawley, Wistar, and Long-Evans
Term
Sialidacryoadenitis Virus and Parker's Rat Coronavirus:
Definition
Prototype viruses.

Cause the inflammation of salivary and lacrimal glands.

Related to the mouse hepatitis viruses.

Transmission: direct contact, aerosol, or fomites.

Widespread and highly contagious.
Term
Rickettsia:
Definition
Haemobartonella muris was once common in lab rats but is now found only in wild rats.
Term
Chromodacryorrhea:
Definition
Secretion of porphyrins from the lacrimal gland.

When excessive it can form red crust around the eye and may run down the nasolacrimal duct to form crust abound the nose.

No treatment. Clean away crust.
Term
Ringtail:
Definition
is a syndrome caused by housed suckling or preweaned rats at low ambient relative humidity.

Usually during winter months.
Term
Dermatophytosis (ringworm:
Definition
In rats is usually caused by Trichophyton mentagrophytes.

Infection may cause widespread skin lesions in a colony or may produce asymptomatic carriers.

Systemic mycoses are extremely rare in rats.
Term
Degloving:
Definition
if tail is degloved, it needs to be amputated at the level of break and sutured closed.
Term
Epileptiform Seizures:
Definition
Gerbils these spontaneous episodes.

Last a few seconds to minutes.

Treatment is not generally recommended.
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