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Side effects of Cards 1-40 in Lange Pharm Flash Card Set
49
Pharmacology
Professional
02/08/2011

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Cards

Term
Penicillin
Definition
Allergic Reactions
Hemolytic Anemia
Term
Ampicillin
Definition
Allergic Reaction
Nonallergic Skin Rash
Diarrhea
Term
Methicillin
Definition
Allergic Reaction
Interstitial Nephritis (methicillin)
Neutropenia (nafcillin)
Hepatitis (oxacillin)
Term
Piperacillin
Definition
Allergic Reactions
Term
Aztreonam
Definition
GI upset
Skin Rash
Elevated LFTs
not a cross-allergen of PCN
Term
Impenem
Definition
GI upset
Allergic Reactions
SEIZURES at high serum levels (Esp in renally insufficient)
Term
Cephalosporins
Definition
Hypersensitivity reaction
Disulfiram-like reaction with ethanol
Nephrotoxocity
Term
Erythromycin
Definition
GI upset
Acute Cholestatic Hepatitis
Skin Rash
Eosinophilia
Increased serum levels of other drugs like warfarin, cyclosporine, and theophylline
Term
Clindamycin
Definition
Nausea/Diarrhea
Skin rashes
Impaired liver function
Psuedomembranous Colitis (clostridium difficile overgrowth)
Term
Gentamicin
Definition
Nephrotoxicity
Ototoxicity
Teratogen
Term
Tetracyclines
Definition
GI upset
Teeth discoloration and bone deformity in children
Faconi Syndrome (aminoaciduria, phosphaturia, acidosis, and glycosuria)
photosensitivity
Dizziness
Don't take with milk, antacids, or iron-containing substances (inhibits absorption)
Term
Rifampin
Definition
Harmless Orange color to urine and sweat
Thrombocytopenia
Nephritis
Hepatitis
Term
Isoniazid
Definition
Peripheral neuropathy
G6PD def hemolytic anemia
Drug induced lupus
Hepatitis
Term
Dapsone (DAP)
Definition
G6PD deficient hemolytic anemia
GI intolerance
rash
Term
Ethambutol (ETH)
Definition
retrobulbar neuritis
Decreased visual acuity
Red green color blindness
Term
Pyrazinamide (PYR)
Definition
GI intolerance
Fever
Hepatotoxicity
Hyperuricemia (gout)
Term
Trimethoprim-Sulfamethoxazole (TMP-SMX)
Definition
Allergic reactions (including Steven-Johnson syndrome)
Hemolytic Anemia
Granulocytopenia
Nephrotoxicity
KERNICTERUS in newborns
Term
Fluoroquinolones--Ciprofloxacin
Definition
GI upset
Skin rash
Headache
Dizziness
Tendonitis
Tendon Rupture in adults
CI in pregnant women and children b/c they damage growing cartilage
Term
Vancomycin
Definition
RED MAN SYNDROME
Injection site irritation
Ototoxicity
Nephrotoxicity
Term
Metronidazole
Definition
HA
Metallic Taste
Disulfiram-like effect with alcohol
Potentiates effect of anticoags
Term
Nucleoside Reverse Transcriptase Inhibitors
Definition
Neutropenia
Megaloblastic Anemia (AZT)
Pancreatitis (ddl)
Peripheral neuropathy (ddc,d4T)
Hypersensitivity reactions (Rash)
Lactic Acidosis (abacavir)
GI upset
Term
Non-Nucleoside Reverse Transcriptase Inhibitors
(Nevirapine)
Definition
Steven-Johnson Syndrome
Fulminant hepatitis
Induction of cytochrome P450, increased metabolism of several drugs including OCs, warfarin, metronidazole, ketoconazole, and some protease inhibitors
Term
Non-Nucleoside Reverse Transcriptase Inhibitors
(Delavirdine)
Definition
HA
Fatigue
Nausea
Rash
Elevated LFTs
Teratogenic Compound
Term
Non-Nucleoside Reverse Transcriptase Inhibitors
(Efavirenz)
Definition
CNS disturbances including:
Insomnia
Dizziness
Delusions
Nightmares
Rash
Term
Protease Inhibitors (Saquinivir, ritonavir, indinavir, nelfinavir, lopinavir, fosaprenavir, etc)
Definition
ALTERED DISTRIBUTION OF BODY FAT
BUFFALO HUMP
INCREASED TRUNCAL OBESITY
Insulin Resistance
HYPERLIPIDEMIA
GI discomfort
Paresthesias
Elevated Bilirubin levels
Kidney stones

Ritonavir--inhibits cytochrome P450 increasing serum levels of various drugs
Term
Acyclovir
Definition
GI upset
neurotoxicity (tremor, delirium)
nephrotoxicity
May crystallize in urinary tract
Term
Ganciclovir
Definition
PANCYTOPENIA
NEPHROTOXICITY
Seizures
HA
Term
Amantadine
Definition
CNS symptoms
Ataxia
Slurred Speech
Dizziness
GI upset
Term
Ribavirin
Definition
Hemolytic Anemia
elevated bilirubin
Teratogenic compound
CI in pregnant and renal insuff
Term
Flucytosine
Definition
Bone marrow suppression
Hepatotoxicity
Term
Amphotericin B
Definition
Infusion related reaction (fever, chills, muscle spasms, HA)
Nephrotoxicity
Abnormal LFTs
Term
Ketoconazole
Definition
Mild GI upset
Abnormal Liver enzymes
Hormone synthesis inhibition (decreased libido, gynecomastia, menstrual irregularities)
Inhibits CP450 so increased serum levels of several drugs
Term
Fluconazole
Definition
Mild GI upset
Abnormal Liver Enzymes
Fever
Chills
Inhibits CP450 so increased serum levels of several drugs
Term
Griseofulvin
Definition
HA
Confusion
GI upset
Allergic Reactions
Hepatitis
Term
Chloroquine
Definition
GI upset
Pruritis
Visual disturbances
ECG changes
Term
Quinine
Definition
Cinchonism (tinnitis, HA, dizziness, nausea)
Coombs positive hemolytic anemia
CI in pregnancy, extremely toxic to fetus
Term
Mefloquine
Definition
Hemolytic Anemia in G6PD patients
Abdominal Pain
CI in pregnancy since may cause hemolytic anemia in fetus
Term
Primaquine
Definition
Hemolytic Anemia
Abdominal Pain
Contraindicated in Pregnancy (anemia in fetus)
Term
Pentamidine
Definition
Nephrotoxicity
Pancreatic Damage
Cardiac Arrythmias
Term
Nifurtimox
Definition
GI upset
Neuropathy
Seizures
Hypersensitivity Reactions
Term
Suramin
Definition
GI upset
Neuro disturbances
Renal abnormalities
Term
Melarsoprol
Definition
Encephalopathy
Hypersensitivity Reactions
GI upset
Renal Damage
Term
Sodium Stibogluconate
Definition
GI upset
ECG changes
Cardiac Arrythmias
Term
Ivermectin
Definition
Mazotti reaction (fever, rash, hypotension, arthralgias, vertigo)
Term
Mebendazole & Albendazole
Definition
GI upset
Allergic Reactions
Term
Thiabendazole
Definition
GI upset
Allergic Reactions
Term
Pyrantel Pamoate
Definition
GI upset
Term
Praziquantel
Definition
GI upset
elevated LFTs
Term
Niclosamide
Definition
GI upset
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