Term
| alternative pathway of compliment |
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Definition
Path initiated by C3
Associated with INNATE immunity |
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Term
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Definition
C3a, C4a, C5a
binding to their receptors on mast cells and basophils induces degranulation |
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Term
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Definition
INH1
Protien that inactivates C3a, C4a, C5a |
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Term
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Definition
| proteolytic fragment of Factor B following cleavage by Factor D. |
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Term
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Definition
Proteolytic fragment of Factor B following cleavage by factor D.
Part of C3 convertase AP |
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Term
| C1 inhibitor protien (C1 INH) |
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Definition
Protien that binds to C1 to prevent activation.
When unbound C1 cleaves C4 and C2 |
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Term
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Definition
| proteins of the classical pathway |
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Term
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Definition
Weak KININ
Increases vascular permeability |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| spontaneous production of C3b which will activate AP |
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Term
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Definition
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Term
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Definition
proteolytic fragment of C3
OPSONIN
activates AP
component of both pathways |
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Term
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Definition
regulatory protien
Binds o C4b to prevent attachment to cells, promotes dissociation of C3 convetase (CP) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| MAC inhibitor, regulatory protien |
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Term
| classical pathway of compliment |
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Definition
| pathway initiated by IgM or IgG |
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Term
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Definition
compliment receptor 1
for C3b |
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Term
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Definition
Compliment receptor 2
for C3bi |
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Term
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Definition
compliment receptor 3a/4a
for those anaphylotoxins |
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Term
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Definition
| Receptor for anaphylatoxin C5a |
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Term
DAF
Decay Accelerating Factor |
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Definition
Regulatory protein
prevents formation of or dissociates C3 convertases |
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Term
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Definition
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Term
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Definition
retulatory protien that binds to C3b
prevents binding of Factor B to C3B and dissociates C3bBb |
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Term
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Definition
Retulatory protien that requires cofactors
Cleaves SOLUBLE forms of C3b, C4b |
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Term
Glycosylphosphatidylinositol (GPI)
clinical |
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Definition
| molecule which attaches some protiens to the cell in lieu of the transmembrane domain |
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Term
hereditary angioedema
(HAE)
clinical |
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Definition
compliment disorder
caused by (genetic) difficiency of C1 IHN |
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Term
Homologous restriction factor
(HRF) |
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Definition
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Term
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Definition
| formed during intrinsic coagulation pathway activation (by Factor XII) |
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Term
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Definition
protien that is a substrate for Kallikrein
Bradykinen is released |
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Term
Membrane Attack Complex
(MAC) |
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Definition
complesx of C5b, 6, 7, 8, 9
Inserts into cell wall causing lysis |
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Term
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Definition
bacterium
MAC protien difficiencies (especially C8) results in recurrent infections with these species |
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Term
Paroxysmal nocturnal hamoglobinuria
(clinical) |
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Definition
| Inherited disorder that manifests as hemolytic anemia because of genetic defect in GPI linkeages |
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Term
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Definition
Stabilizes alternative pathway
C3bBb |
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Term
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Definition
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Term
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Definition
AP and CP
converge to form this path
resulting in MAC |
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Term
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Definition
| MAC inhibitor - regulatory protien |
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Term
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Definition
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