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Definition
(procovertin)
small amt VIIa binds with Tissue factor
-activates IX-->IXa
-activates X-->Xa
*part of the EXTRINSIC coagulation pathway*
**shortest 1/2 life** 3-6hrs
Synthesized in liver |
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Definition
(thromboplastin)
Txmembrane ptn
Co-factor for Factor VIIa, txmits intracell signal
-activates IX-->IXa
-activates X-->Xa
*part of the EXTRINSIC coagulation pathway*
*Needed for vascular integrity* |
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activated by XIa
-with cofactor VIIIa, activates X-->Xa |
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Definition
Activates platelets-->exposure of phosphatidyl serine (allows coagulation factors that are Vit K-dep to bind to surface)
-Activates XI-->XIa (which activates IX-->IXa)
-Activates VIII-->VIIIa (which is a co-factor for IXa's activ of X)
-Activates V-->Va (which is a co-factor for Xa's activation of prothrombin)
-leads to formation of fibrin clot
-Factor XIII (stabilizes fibrin)
-thrombomodulin (activates ptn C
-TAFI (thrombin activatable finrinolysis inhibitor)
-PARs 1,3,4
C5 (complement)
Osteopontin (Th1 cytokine) |
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Term
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Definition
activated by both:
1) VIIa (from VII and TF complex)
2)IXa + VIIIa cofactor |
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Term
| Extrinsic coagulation cascade |
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Definition
Initiates most coagulation
Generally: VII-->VIIa-->activates X-->Xa
-TF + VIIa allows activation of X and IX |
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Definition
aka contact pathway (activated by surface contact)
- positive feedback loop
-Greatly increases thrombin production
Generally: XII-->XI-->IX+(VIII)-->X
*PK(prekallikrein) activates XII with HMWK (high MW kininogen) cofactor
*XII activates XI
Initiate thrombus formation in vitro (PTT) |
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Term
| Secondary Hemostasis - better image |
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Definition
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Term
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Definition
(Christmas factor)
*intrinsic pathway*
-activated by XIa; TF/VIIa
-activates: X-->Xa (+VIIa cofactor)
Deficiency: hemophilia B |
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Definition
*intrinsic pathway*
-activated by: thrombin
Deficiency: Hemophilia A |
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Definition
Generally: X(+V)-->II(prothrombin)-->fibrinogen
-X activated byTF/VIIa (extrinsic Xase) and IXa/VIIIa (intrinsic Xase) |
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Term
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Definition
Activated by: TF/VIIa (extrinsic Xase); IXa/VIIIa (intrinsic Xase
Activates: Prothrombin (II)+Va cofactor --> thrombin
*thrombin activates V->Va too (small loop)
*Xa is a target for anti-coagulation* |
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Definition
-Upregulates its own production (V, VII, XI)
-Downregulates its own production (activ of ptn C when assoc with thrombomodulin) |
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Definition
-Dimer of three pairs of chains (Aα, Bβ, γ)
-A and B are cleaved from Aα, Bβ chains by thrombin
***Fibrinopeptide A is only one required for fibrin polymer formation*** |
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Term
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Definition
Activated by thrombin
-cross links fibrin monomers at γ and α chains
-cross links α-2 antiplasmin (inhib fibrinolysis) into fibrin clot
Deficiency: severe bleeding
**longest 1/2 life** 10days |
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Definition
Factors II, VII, IX, X
Proteins C and S
-co-factor for carboxylating Glu residues in Gla domain
-allows for Ca2+ dependent binding of phospholipids
*warfarin (coumadin) is vit K antagonist --> low levels of these factors
*Newborns are given Vit K at birth |
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Definition
required for homeostasis
-Citrate, EDTA are calcium chelators/anticoagulants |
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Definition
(fibrinogen)
synthesized in liver |
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Definition
(prothrombin)
synthesized in liver |
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Definition
(prothrombin accelerator)
synthesized in liver/MKcytes
-activated by thrombin
-cofactor for Xa to activate prothrombin |
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Definition
synthesized in liver/endothelium
-activated by thrombin
-cofactor for IXa to activate factor X
-part of the intrinsic "ten-ase" |
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Definition
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Definition
Tissue factor pathway inhibitor
-membrane bound & soluble forms
-binds to TF/VIIa/Xa complex, shuts down extrinsic pathway |
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Definition
-on endothelial cells, mostly
-binds to/alters thrombin activity
-Decreased activ of fibrinogen, V, VIII, XI, PARs
-Increased activ of ptn C and TAFI
*ptn C degrades co-factors(V and VIII) with ptn S as co-factor |
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Definition
thrombin activatable fibrinolysis inhibitor
*inhibits fibrinolysis*
-cross linked with fibrin monomers by XIIIa to make a stable fibrin clot
-cleaves tPA and plasmin binding sites off of fibrin |
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Term
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Definition
-VitK dependent
-PtnC --> APC via thrombin-thrombomodulin complex; inactivates Va and VIIIa with ptnS cofactor
-factorV Leiden - can't be degraded by ptn C - most common cause of inherited hypercoagulability |
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Definition
serine protease inhib
-inhib activity of Xa and thrombin
requires heparin co-factor |
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Definition
-cleaves fibrin into products taht inhib XS clot formation
-activated from plasminogen by tPA (tissue plasminogen activator) and uPA (urokinase-type plasminogen activator) |
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Definition
directly inhibits plasmin
*fibrinolysis inhibitor* |
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Definition
Concentrate fibrinogen in cryprecipitate
-three alpha beta gamma chains stuck together by E ptn
-thrombin cleaves fibrinopeptides A and B off to convert fibrinogen --> fibrin
-fibrin polymerizes if monomers are proximal
-Factor VIII (activated by thrombin) stabilizes fibrinogen gel --> mesh |
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Definition
| Plasmin splits fibrinogen into fibrinogen split products and D dimers |
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Definition
Great lab value for DIV, DVT/PE
Product of fibrinolysis by plasmin |
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