Olanzapine

dyslipidemia

sedation

type 2 dm

weight gain

clozaril

anticholinergic

dyslipidemia

postural hypotension

sedation

seizures

type 2 dm

weight gain

agranulocytosis

wbc < 3500

anc < 2000

potentially fatal

can result in opportunistic infections

can occur in clozaril treated patients 

• third line treatment
• due to agranulocytosis
• treats negative symptoms of schizophrenia better than other antipsychotic medications 
• patient must be on clozaril national registry
• wbc monitored weekly, then every two weeks then every four weeks

• Extra-Pyramidal Symptoms
• parkinsonism
• akathesia
• dystonia
• tardive dyskinesia

tremor

bradykinesia

rigidity

resting 

rhythmic

course 

affects the limbs, head, mouth, tongue

• subjective: 
• inner restlessness, 
• urge to move
• irritability
• objective: 
• crossing/uncrossing legs, 
• restless legs
• lifting feet

cogwheel

lead pipe