Term
| schizophrenia has what two SYMPTOM CLASSES? examples |
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Definition
POSITIVE: delusions, hallucinations, bizarre thoughts
NEGATIVE: apathy, ambivalence, blunted affect |
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Term
| in general, what drugs to POSITIVE SYMPTOMS respond to? |
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Definition
CLASSICALS-->
-chlopromazine
-fluphenazine
-haloperidol
-trifluorperazine |
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Term
| two classes of ANTIPSYCHOTIC DRUGS |
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Definition
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Term
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Definition
EXCESS dopaminergic activity-->limbic system--> + symptoms
REDUCES dopaminergic activity-->prefrontal cortex--> - symptoms |
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Term
| what do CLASSIC antipsychotics block? ATYPICAL antipsychotics? |
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Definition
CLASSICAL--> D2 receptor block
ATYPICAL--> D2 and 5HT receptor block |
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Term
| dopamine/prolactin relation? |
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Definition
| dopamine normally inhibits prolactin release--> chronic users of ANTIPSYCHOTICS may develop GYNECOMASTIA or may LACTATE |
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Term
| classic antipsychotic side effects- |
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Definition
-increase QRS complex-->arrhythmias
-autonomic toxicity--> orthostatic hypotension
-extrapyramidal effects
***TARDIVE DYSKINESIAS-involuntary movements, often facial with TONGUE PROTRUSION, incurable |
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Term
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Definition
schizophrenia
psychosis
Tourette syndrome
antiemetic |
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Term
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Definition
CLASSIC drug
-rare CHOLESTATIC JAUNDICE--> raised alkaline phosphatase |
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Term
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Definition
CLASSIC drug
-FDA approved ANXIOLYTIC |
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Term
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Definition
CLASSIC drug
-Intramuscular DEPOT preparation (slow release) |
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Term
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Definition
CLASSIC drug
-FATAL ARRHYTHMIAS from increased QRS complex |
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Term
| ***butyrophenones (haloperidol)*** |
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Definition
HALOPERIDOL is a CLASSIC antipsychotic
-used in TOURETTE SYNDROME and STUTTERING
side effects:
-SERIOUS EPS
-TARDIVE DYSKINESIA |
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Term
| specifics of ATYPICAL ANTIPSYCHOTIC drugs |
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Definition
| -low potency -block D2 and 5HT |
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Term
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Definition
ATYPICAL antipsychotic
-low 5HT receptor affinity--> minimal weight gain
-metabolized by cyp450 |
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Term
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Definition
ATYPICAL antipsychotic
-FDA approved for BIPOLAR and MANIA |
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Term
| what is NEUROLEPTIC MALIGNANT SYNDROME |
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Definition
-occurs early in treatment or with increased dose
symptoms:
-fever
-muscle rigidity
-altered consciousness
-autonomic instability
-elevated serum creatine phosphate phosphokinase
***stop drug and treat with DANTROLENE (blocks ryanodine receptors) |
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Term
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Definition
-used when classicals don't work
-autonomic toxicity possible aplastic anemia and -**FATAL AGRANULOCYTOSIS
**must have WEEKLY BLOOD TESTS done |
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