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S09 Pathology 2c
Respiratory / GI
92
Other
Professional
07/20/2009

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Term
Upper
Definition
___ respiratory infections are the most common respiratory problem. They are self-limiting and include the common cold caused by viruses.
Term
Middle
Definition
___ respiratory syndromes are usually childhood and include croup and bronchiolitis.
Term
Lower
Definition
___ respiratory tract disease can occur at any age and include pneumonia.
Term
Croup
Definition
___ is the barking cough middle respiratory syndrome.
Term
Pneumonia
Definition
___ is acute inflammation of the lung.
Term
Pneumonia
Definition
___ is the #5 cause of death in USA, #3 in children <3years. Microscopically it is an acute inflammation.
Term
Focal Fibrosis
Definition
Pneumonia heals by ___ ___.
Term
With antibiotics and it can affect one or both lungs (double pneumonia)
Definition
How is pneumonia treated?
Term
1. Strep pneumoniae / 2. Haemophilus influenzae / 3. Staph aureus
Definition
What three bacteria are the most common causes of pneumonia?
Term
Influenza virus / Herepesvirus / Cytomegalovirus / and can be reactivated in the immunosuppressed
Definition
Which viruses cause pneumonia?
Term
Aspergillus flavus / Candida albicans / Pneumocystic carinii
Definition
Which fungi can cause pneumonia?
Term
Mycoplasma pneumoniae
Definition
___ ___ is a bacteria-like organism that cause pneumonia.
Term
Hemoptysis
Definition
___ is blood in sputum.
Term
Alveolar
Definition
___ pneumonia is inflammation of the air sac spaces. It is usually bacterial.
Term
False! Bacterial!
Definition
T/F: Alveolar pneumonia is usually viral.
Term
Interstitial
Definition
____ pneumonia affects the area in the lungs between the cells (connective tissue of the lung). Inflammation is usually in the septum and is often viral.
Term
True! Alveolar is bacterial!
Definition
T/F: Interstitial pneumonia is usually viral.
Term
Bronchopneumonia
Definition
___ is deeper in the lung and can affect on or both lungs.
Term
Aspiration
Definition
___ pneumonia is caused by throwing up while unconscious.
Term
Mycobacterium
Definition
____ is the causative organism in tuberculosis.
Term
Primary
Definition
___ tuberculosis is most commonly a localized lung inflammation.
Term
Ghon focus
Definition
___ ___ is a small focus of tuberculosis pneumonia in the mid lung.
Term
Ghon Complex (aka Scrofula)
Definition
____ ___ develops in Primary tuberculosis if it also involves regional lymph nodes.
Term
A. Pleural surface / B. Lung parenchyma / C. Contralateral lung
Definition
Explain tuberculosis' lymphatic spread.
Term
A. Bronchial spread in the same lung / B. Spread to the larynx / C. Aspirated TB swallowed into the esophagus leads to intestinal TB
Definition
Explain the tuberculosis spread through airways.
Term
Meningitis, tuberculosis of the urogenital tract and bone tuberculosis
Definition
Explain tuberculosis' hematogenous spread.
Term
80-90%
Definition
What percentage of COPD sufferers are smokers?
Term
Chronic Obstructive Pulmonary Disease (Chronic bronchitis)
Definition
______ is a clinical syndrome characterized by coughing up sputum on most days for at least 3 months a year for 2 or more years.
Term
A clinical syndrome characterized by coughing up sputum on most days for at least 3 months a year for 2 or more years.
Definition
Explain what COPD is.
Term
Emphysema, it is associated with chronic bronchitis but is not the result of it.
Definition
___ is the enlargement of the air spaces distal to the terminal bronchiole, with destruction of the alveolar wall. It affects chronic cigarette smokers.
Term
False, irreversible
Definition
T/F: The pulmonary lesions of emphysema are reversible.
Term
Emphysema
Definition
___ is also called pink puffer, presenting clinically with barrel chest, dyspnea, hunched-over, trying to expel air, hyperventilation.
Term
Chronic bronchitis, emphysema
Definition
What are the two diseases associated with COPD?
Term
Asthma
Definition
___ is an episodic reversible bronchoconstriction resulting from increased responsiveness of the airway to various stimuli. It is a common, multifactorial disease.
Term
Asthma
Definition
___ presents clinically with cough, wheezing, and dyspnea. It affects 5% of adults, 10% of kids, M>F and causes 6000 deaths a year.
Term
False! Males > females
Definition
T/F: Asthma affects females > males.
Term
histamine and cytokine release
Definition
All types of asthma result in ___ and ___ release. These cause episodic bronchospasm (smooth muscle contraction), hypersecretion of mucus and diminished ciliary activity.
Term
Steroids or bronchodilators
Definition
How is asthma treated?
Term
Sarcoidosis
Definition
___ is a multi-system disease with unknown etiology. It is characterized by non-caseating, hard granulomas most commonly in lymph nodes, lungs and spleen. Can be seen in oral cavity also.
Term
True! Twice as common in black women than men.
Definition
T/F: Blacks are most commonly affected with sarcoidosis.
Term
75%
Definition
___% of sarcoidosis patients are asymptomatic with potato nodes (enlarged lymph nodes in hilar lung) or fibrosis on routine chest x-ray.
Term
Sarcoidosis
Definition
Shortness of breath and cough are symptoms of a disease that affects more blacks than white and is characterized by non-caseating granulomas.
Term
True! Corticosteroids to treat advanced disease
Definition
T/F: Most sarcoidosis patients recover with no treatment.
Term
10% / 4%
Definition
___% of sarcoidosis patients experience progressive pulmonary fibrosis that can cause cor pulmonale and __% die of disease.
Term
Hypersensitivity pneumonitis, patients are abnormally sensitive to the dusts
Definition
___ ___ is also called allergic alveolitis. It is an immune mediated lung disease caused by inhalation of organic dusts.
Term
moldy hay and actinomycetes
Definition
Farmer's lung is caused by exposure to ___ ___ and ____.
Term
water reservoir and actinomycetes
Definition
Humidifier lung is caused by exposure to ___ ___ and ____.
Term
pigeon droppings and serum
Definition
Pigeon Breeder's disease is caused by exposure to pigeon ___ and ___.
Term
Pneumoconiose
Definition
___ is a lung disease caused by inhalation of mineral dusts, fumes, etc. It is a consequence of long term exposure and the most important diseases of this group are silicosis, asbestosis and coal-worker's lung disease.
Term
Pneumoconiose
Definition
Silicosis, asbestosis and coal-worker's lung disease are important diseases of this group:
Term
asbestosis
Definition
___ is caused by a carcinogenic mineral used in manufacturing and industry for many years. It leads to pulmonary fibrosis, pleural fibrosis, pleural plaques, lung cancer and mesothelioma.
Term
#1
Definition
Lung cancer is the #__ cause of cancer death in industrialized countries.
Term
10-15%
Definition
Lung cancer has a poor prognosis, 5year survival rate is ___-___%.
Term
Squamous cell carcinoma
Definition
___ ___ ___ is the most common type of lung cancer. It typically affects male smokers, usually central in the lung and is slow growing and may be resectable.
Term
False! Male smokers
Definition
T/F: Squamous cell carcinoma typically affects female smokers.
Term
Adenocarcinoma
Definition
___ is not as strongly linked to smoking. It affects males and females at the same rate. It usually is found at the periphery of the lung and doesn't obstruct the airway, causing it to be diagnosed late.
Term
False! Adenocarcinoma is not as strongly linked to smoking as squamous cell carcinoma
Definition
T/F: Squamous cell carcinoma is not as strongly linked to smoking as adenocarcinoma.
Term
adenocarcinoma
Definition
___ frequently leads to extensive metastases because it does not obstruct the airway causing it to be diagnosed late.
Term
Small (oat) cell carcinoma
Definition
____ cell carcinoma is highly malignant and strongly linked to cigarette smoking. It causes a central or hilar lesion and is almost always inoperable.
Term
Large cell carcinoma
Definition
___ cell carcinoma is poorly differentiated so it cannot be classified as other type. There is a poor prognosis.
Term
Nasopharyngeal carcinoma
Definition
___ carcinoma is strongly linked to EBV. There is a high frequency in southeast asia and metastasizes early. Lump in neck is often the presenting sign.
Term
digestion and ailmentation
Definition
The main function of the gastrointestinal tract is ___ and ___.
Term
squamous, glandular, squamous
Definition
The GI tract is a hollow tube made up of ___ epithelium, lower part of ___ epithelium and then ___ epithelium again.
Term
Upper
Definition
___ tract of the GI includes the mouth, pharynx, esophagus, stomach and duodenum.
Term
Lower
Definition
___ tract of the GI includes small and large intestine, appendix, rectum and anus.
Term
Mallory-Weiss Tear
Definition
A ___-___ ___ is a laceration that causes 10-15% of upper GI bleeds. Bleeding is usually moderate and surgery is not required.
Term
Hiatal hernia
Definition
___ ___ is when a portion of the stomach protrudes through the edge of the diaphragm. It is extremely common and often asymptomatic. It is more common in adults and increases the risk for GERD.
Term
GERD
Definition
___ is the #1 type of esophagitis. It is caused by frequent reflux of stomach contents into the esophagus due to an incompetent lower esophageal sphincter.
Term
Barrett's esophagus
Definition
GERD sometimes progresses to ___ ___. Mucosa is more sensitive to injury.
Term
Adenocarcinoma
Definition
The following describes (Squamous cell/adenocarcinoma): less common, lower esophagus, Barret's esophagus leads to metaplasia.
Term
Squamous cell
Definition
The following describes (squamous cell/adenocarcinoma): more common, middle esophagus, smoking/alcohol/diet, p53 mutation in 50%.
Term
Pyloric stenosis
Definition
___ ___ is a congenital hypertrophy of muscle of pyloric sphincter. It blocks the exit of stomach contents and causes projectile vomiting at age 3-4 weeks. Myotomy surgical correction possible.
Term
Helicobacter / NSAIDs
Definition
Chronic peptic ulcers have a strong association with ____ and ___.
Term
more common in older adults
Definition
Chronic gastritis is more common in who? Also metaplasia gives increased risk of gastric adenocarcinoma.
Term
Acute gastritis
Definition
(Acute/Chronic) gastritis may cause hemorrhage or erosion. It is caused by damage to the mucosal barrier by NSAIDs, alcohol, tobacco, or critical illness.
Term
False!
Definition
T/F: Gastric adenocarcinoma is found more common in North America than Japan.
Term
Gastric adenocarcinoma
Definition
___ ___ is caused by salt, smoked food, chronic atrophic gastritis with intestinal metaplasia, helicobacter or p53 mutation.
Term
Ischemic bowel disease
Definition
___ ___ ___ is usually found in older patients with severe atherosclerosis. Not as much blood flow due to hardening of arteries.
Term
Ulcerative colitis
Definition
___ ___ is ulceration affecting only the colon. It is characterized with episodes of bloody diarrhea with spontaneous remissions. High risk of bowel cancer.
Term
Crohn's Disease
Definition
___ ___ is chronic granulomatous inflammation of any part of the GI tract. "Gum to Bum"
Term
Crohn's disease
Definition
A patient with ___ ___ has sharply demarcated segments separated by normal bowel (skip lesions).
Term
Crohn's disease
Definition
Complications of ___ ___ include: systemic disease (skin / skeletal muscle / joints / liver / eye / lung), obstruction of GI lumen, fistulas to bowel and other organs, increased cancer of small or large bowel.
Term
Crohn's disease
Definition
___ ___ has an increased risk of cancer in small and large bowel, but is much lower than in ulcerative colitis.
Term
Familial adenomatous polyposis
Definition
___ ___ ___ is when hundreds of adenomas carpet the colon. 100% get colon cancer young. To treat you must remove entire colon.
Term
Gardner Syndrome (early detection by dental staff may save life)
Definition
___ ___ is characterized by osteomas, multiple impacted teeth, multiple supernumerary teeth, colon adenomas progress to colon cancer.
Term
Peutz-Jegher's Syndrome
Definition
____-____ syndrome is a type of hereditary intestinal polyposis where multiple colon polyps (hamartomas not adenomas) increase risk of colon carcinoma but not usually malignant.
Term
Peutz-Jegher's Syndrome
Definition
Pigmentation is classically noted clinically around facial orifices, intraorally, and occasionally on hands and feet in ____-____ ____. Bowel polyps may cause intersusseption or obstruction.
Term
#2, 95%
Definition
Colon malignancies are the #___ cause of cancer death. ___% are adenocarcinoma.
Term
colorectal adenocarcinoma
Definition
Adenomatous polyps are always the precursor to ___ ___.
Term
over 50%
Definition
Overall, colorectal adenocarcinoma's prognosis is ___% 5 year survival rate.
Term
50yrs / 40yrs
Definition
Screening for colon cancer should start at ___ years, or ___ years if patient has relative with colon cancer.
Term
Colonoscopy
Definition
___ can remove adenomas before they become cancers. This may prevent many cases of colon cancer.
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