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S09 Pathology 1d
Quiz 4
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06/09/2009

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Term
hyperemia
Definition
___ is the excess of blood in an organ.
Term
active
Definition
___ hyperemia is due to an increased supply of blood such as the dilation of arteries.
Term
active
Definition
___ hyperemia is dark red in color.
Term
passive
Definition
___ hyperemia is due to congestion or the blockage of blood's exit such as the blockages of veins.
Term
passive
Definition
___ hyperemia is blue-red in color.
Term
hemorrhage
Definition
___ is bleeding from blood vessels usually caused by trauma. They may also be caused by surgery, aneurysms, infections, fragile blood vessels or coagulation disorders.
Term
hemorrhage
Definition
___ may be caused by trauma, surgery, aneurysms, infections, fragile blood vessels or coagulation disorders.
Term
False! A hematoma (bleeding into soft tissue) does not blanch, but a hemangioma (benign neoplasm) does. This test is called a diascopy.
Definition
T/F: Hematoma blanches with pressure while hemangioma does not.
Term
hypovolemic shock = >20%
Definition
A loss of >20% of blood may lead to ___ ___.
Term
10% = donate blood
Definition
When you donate blood, you lose approximately ___%.
Term
20% = sick feeling
Definition
After losing ___%, you will probably feel sick.
Term
40% = hypovolemic shock
Definition
After losing ___% of blood, you will probably experience hypovolemic shock.
Term
exsanguination
Definition
___ is bleeding to death.
Term
hemothorax
Definition
___ is hemorrhaging into the pleural cavity.
Term
hemopericardium
Definition
___ is hemorrhaging into the pericardial sac.
Term
hemarthrosis
Definition
___ is hemorrhaging into a joint space.
Term
Hematoma
Definition
___ is hemorrhaging into soft tissue.
Term
petecchiae
Definition
___ are pinpoint bleeds ranging from 1mm - 3mm.
Term
palate
Definition
Where is the most common site for petecchiae?
Term
purpura (which means "purple")
Definition
___ are larger hematomas, ranging from >3mm - <1cm.
Term
ecchymosis
Definition
___ is a bruise >1cm.
Term
shock
Definition
___ is the widespread hypoperfusion due to reduction in blood volume, cardiac output, or the redistribution of blood resulting in reduction in effective circulating blood volume.
Term
cardiogenic shock = heart fails to pump adequately
Definition
___ shock is the failure of the heart to pump adequately.
Term
hypovolemic shock
Definition
___ shock is the inadequate volume of blood due to dehydration, exsanguination or ruptured organ.
Term
shock (both hypovolemic and cardiogenic)
Definition
Tired, weak pulse, grey / cool / clammy skin and the reduction in blood pressure are clinical signs of ____.
Term
septic shock
Definition
___ shock is due to an infection leading to peripheral pooling, direct injury, inflammatory / immune activation by endotoxins, multisystem failure or even death.
Term
septic shock
Definition
___ is clinically characterized by warm, flushed skin due to peripheral vasodilation caused by g(-) bacterial endotoxins affecting blood vessels.
Term
neurogenic shock
Definition
Anesthesia, spinal cord injury, periperhal vasodilation and blood pooling may cause ___ shock.
Term
neurogenic shock
Definition
___ shock is the injury of nerves leading to no muscle contraction causing blood pooling.
Term
Right = deoxygenated coming from body / going to lungs
Left = oxygenated coming from lungs / going to body
Definition
Deoxygenated blood is handled by the ___ side of the heart while oxygenated blood is handled by the ___ side.
Term
congestive heart failure
Definition
___ ___ ___ occurs when the heart is unable to pump enough oxygenated blood to meet the requirements of the tissues. It is usually caused by the failure of muscle to contract properly due to ischemic injury, valve disease, or other heart abnormalities.
Term
congestive heart failure
Definition
Fatigue and shortness of breath are clinical signs of what disease that affects 10 out of 100 people?
Term
heart failure
Definition
Muscle damage, high work load and inefficient function are the three top causes of ___ ___.
Term
Muscle damage (heart attack), high work load (high blood pressure), inefficient function (heart valve disease)
Definition
What are the top 3 causes of heart failure?
Term
hypertrophy
Definition
___ enlarges the heart in congestive heart failure. It increases capacity but also increases the metabolic demands.
Term
cardiomegaly
Definition
___ is the enlargement of the heart caused by hypertrophy to compensate for congestive heart failure
Term
True!
Definition
T/F: Usually the right and left sides of the heart fail together.
Term
left heart failure
Lungs --> atrium --> ventricle --> aorta.
Definition
___ heart failure is more severe. It causes problems with atrium / ventricle leading to extra pressure in lungs.
Term
left side heart failure
Definition
___ side heart failure may lead to pulmonary congestion, pulmonary edema, or kidney failure.
Term
dypsnea, orthopnea
Definition
___ is difficulty breathing. ___ is difficulty breathing especially while lying down. These are both signs of pulmonary edema caused by left side heart failure.
Term
paroxysmal nocturnal dyspnea
Definition
___ ___ ___ is the gasping for breath at night. The patient may need several pillows to sleep. This is caused by pulmonary edema due to left side heart failure.
Term
fluid in lungs
Definition
Cough and acute pulmonary edema are caused by ___ ___ ___ due to left side heart failure.
Term
heart failure cells
Definition
___ ___ cells are erythrocytes engulfed by macrophages causing them to appear red.
Term
heart failure cells
Definition
___ ___ cells are hemosiderin-laden macrophages.
Term
cor pulmonale
Definition
___ ___ is when only the right side of the heart is diseased.
Term
right side
Definition
Cor pulmonale is when only the ___ side of the heart is diseased.
Term
False! Vice versa... Right heart failure is almost always caused by left heart failure because it increases the workload of the right heart.
Definition
T/F: Left side heart failure is almost always due to right heart failure because it increases the workload of the left side.
Term
right heart failure
Definition
Blood backs up systemically and also into the portal (liver) system in ___ heart failure.
Term
right
Definition
Pitting edema of the ankles is due to the peripheral edema caused by ___ side heart failure.
Term
Right / Sclerosis is caused by blood vessels becoming compressed due to collagen and it is firm to the touch
Definition
"Nutmeg liver" and sclerosis of the liver are caused by ___ heart failure.
Term
True! Otherwise they may experience pulmonary edema and dyspnea while laying down.
Definition
T/F: You should sit a patient with congestive heart failure up as much as you can.
Term
Ischemic heart disease
Definition
___ heart disease is the imbalance between oxygen supply and the demand on the heart. The heart muscle does not get enough oxygen causing muscle cells to die.
Term
atherosclerosis
Definition
Ischemic heart disease is usually caused by ____ and causes 1/3 of US deaths.
Term
Atherosclerosis
Definition
___ is when the build up of plaque in the wall of an artery gradually occludes the lumen.
Term
atheroma
Definition
___ is the plaque build up composed of lipid, smooth muscle and fibrous tissue that occludes artery lumens.
Term
coronary
Definition
Atherosclerosis of the ___ arteries may cause ischemic heart disease or myocardial infarction.
Term
cerebral arteries (stroke) / aorta (aneurysm)
Definition
Atherosclerosis of the ___ arteries may cause a stroke. Atherosclerosis of the ___ may cause an aneurysm.
Term
atherosclerosis
Definition
HTN, acquired hyperlipidemia, cigarette smoking and diabetes mellitus are the 4 most common risk factors of ___.
Term
False! Vice versa! Post-menopausal women experience atherosclerosis at the same rate as men while it is almost unheard of in pre-menopausal women.
Definition
T/F: Pre-menopausal women experience atherosclerosis at the same rate as men while it is almost unheard of in post-menopausal women.
Term
low / high
Definition
___ density lipoproteins are deposited whereas ___ density lipoproteins help with metabolism of lipids.
Term
True! Also, periodontal disease has association with presence of atherosclerosis
Definition
T/F: Dental disease puts patient at high risk for cardiovascular disease and strokes.
Term
C-reactive protein
Definition
___ ___ is a strong predictor for atherogenesis. It is produced by the liver in acute inflammation. It is also elevated in periodontitis as well as atherosclerosis.
Term
False! Fatty streaks are NOT atherosclerosis... but they are found in normal arteries, even children.
Definition
T/F: Locations of fatty streaks correspond to sites of atheroscleosis and may be seen in normal arteries, even in children.
Term
1. Platelet adhesion, 2. release of factors, 3. smooth muscle constricts, 4. accumulation of collagen, 5. enhanced deposition of lipids
Definition
Explain the development of a fatty streak.
Term
atheroma
Definition
___ (a necrotic mass of lipid) makes up simple plaque along with a fibrous cap.
Term
simple plaque
Definition
___ plaque contains an atheroma, fibrous cap, fat-filled macrphages (foam cells), smooth muscle cells, and activated t-lymphocytes.
Term
atherosclerosis
Definition
___ plaque is 1-3cm usually found in the lower abdominal aorta, coronaries, politeals, descending thoracic aorta, internal carotids and circle of Willis.
Term
thrombosis
Definition
A ___ is a solid mass of coagulated blood inside the cardiovascular system. It can be life-saving or life-threatening.
Term
thrombosis
Definition
___ is caused by endothelial damage, alterations in blood flow or hypercoagulability.
Term
False! Vice versa!! Deep vein thrombosis can embolize, especially to lungs and be fatal. Superficial thrombosis rarely embolize and may cause statis ulcers.
Definition
T/F: Superficial thrombosis can embolize, especially to lungs and be fatal. Deep vein thrombosis rarely embolize and may cause statis ulcers.
Term
thrombus
Definition
Lysis/Resolution, propagation, organization, recanalization and embolism is the fate of a ____.
Term
embolism
Definition
___ is the occlusion of blood vessels by a mass transported by the bloodstream. Almost all are embolizing thrombus (thromboemboli).
Term
Embolism
Definition
Most ___ are from deep vein thrombosis and often end up in lungs.
Term
Brain / heart / kidney / intestine / legs / lungs
Definition
___ embolism = stroke / ___ embolism = MI / ___ embolism = renal infarct / ___ embolism = intestinal infarct / ___ embolism = gangrene / ___ embolism = pulmonary embolism
Term
ischemic heart disease
Definition
___ ___ ___ is usually atherosclerosis plus increase O2 demand and decreased O2 supply caused by anemia, platelet plug, thormbosis, hemorrhage into atherosclerotic plaque or vasospasm.
Term
angina pectoris
Definition
___ ___ is paroxysmal substernal chest pain lasting for a brief time, caused by transient myocardial hypoxia. The damage reversible.
Term
mandible
Definition
Angina pectoris may refer pain to ___.
Term
myocardial infaction
Definition
___ ___ is ischemic necrosis in the myocardium. Left heart is more often affected than right heart.
Term
False! Reversible damage
Definition
T/F: Angina pectoris causes irreversible damage.
Term
coagulation
Definition
___ necrosis may cause myocardial infarction. It then heals by fibrosis.
Term
mural
Definition
___ thrombus formation is a thrombus in the endocardium.
Term
chronic ischemic heart disease, major cause of unexplained heart failure, may accompany MI, usually leads to death through congestive heart failure
Definition
___ ___ heart disease is the most common cardiac disease.
Term
160/95mmHg
Definition
Hypertension = blood pressure higher than ___/___ mmHg.
Term
120mmHg (Remember: systolic/diastolic)
Definition
Malignant hypertension = diastolic pressure higher than ___mmHg.
Term
primary, secondary
Definition
90% of HTN is ___. (Blacks > whites) 10% is ___.
Term
hyaline / hyperplastic
Definition
___ arteriosclerosis is a mild disease with diffuse thickening of vessel walls. ___ arteriosclerosis is more deadly and is characterized by onion-skin thickening of vessel walls.
Term
benign / malignant
Definition
___ nephrosclerosis results from mild arteriosclerosis. ___ nephrosclerosis results from hyperplastc arteriosclerosis.
Term
rheumatic fever
Definition
___ ___ is an immune-related inflammatory disease usually in children following infection by group A beta-hemolytic streptococci.
Term
group A beta-hemolytic streptococci
Definition
Rheumatic fever usually occurs in children following an infection by what?
Term
strep throat
Definition
Triggering infection for rheumatic fever is usually ___ ___.
Term
1. congenital heart disease
2. mechanical / artificial heart valves
3. previous infective endocarditis
Definition
Who is at risk for infective endocarditis?
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