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Rickettsia
BBD Lec 4/7 @11AM
24
Medical
Professional
04/07/2010

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Term
Describe of unique unique features of the Rickettsia group of bacteria.
Definition
LO
Term
Describe the epidemiology, clinical manifestations, and mode of transmission of the spotted fever group of Rickettsia and the typhus group of Rickettsia.
Definition
LO
Term
Describe the general features, epidemiology, and clinical manifestations of the diseases associated with Bartonella henselae.
Definition
LO
Term
What is the vector of Rickettsia and Bartonella?
Definition
arthropod vectors with humans being an accidental host.
Term
are these bacteria or viruses?
Definition
bacteria.
Term
where is the only place they grow in a host?
Definition
ONLY cytoplasm of eukaryotic cells
Term
how does rickettsia get into the cytoplasm of a eukayote?
Definition
they escape the phagosome (via phospholipase).
Term
can you grow rickettsia on an agar plate?
Definition
NO. Only inside living host cells.
Term
what bug causes Rocky Mountain Spotted Fever (RMSF)?
Definition
Rickettsia rickettsii
Term
how high is the mortality rate of Rocky Mountain Spotted Fever if untreated?
Definition
25%
Term
what is the main vector of RMSF in the eastern USA?
Definition
the dog tick. (it is a parasite of various species of ticks)
Term
what area of the USA does the wood tick transmit RMSF?
Definition
western
Term
what are the chances a tick is infected with the bacterium?
Definition
5% or 1 in 20 ticks.
Term
what diagnostic feature do you see on the palms/wrists and soles/ankles of some with RMSF?
Definition
rash
Term
what is transovarial transmission?
Definition
babies of an infeced arthropod are infected too.
Term
what is the minimum exposure time to an infected tick for transmission to occur?
Definition
6 hours
Term
what is meant by "petechial"?
Definition
erythmatous macules caused by bleeding underneath the skin.
Term
why is mortality rate higher in people with dark skin?
Definition
they cant see the red spots.
Term
what bug causes Louse-Borne Typhus Epidemic Fever?
Definition
Rickettsia prowazekii
Term
how is this disease transmitted?
Definition
body louse.
Term
where does the rash start?
Definition
on the trunk
Term
how does the the Louse-Borne Typhus Epidemic Fever start?
Definition
Epidemic typhus starts with the feeding of the body louse on a patient with an acute febrile infection.
Term
what is the causative agent of Cat Scratch Fever?
Definition
Bartonella henselae
Term
what is the vector for B. henselae?
Definition
transmitted cat to cat by fleas. (up to 25K cases/year)
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