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UMB Rhythm Disturbances 2 - PHAR550
Rhythm Disturbances 2 - PHAR550
34
Pharmacology
Professional
01/17/2014

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Cards

Term
How are supra-ventricular arrhythmias, bradycardia, and heart block treated?
Definition
Pacemaker
Term
How is sinus tachycardia treated?
Definition
Remove the offending cause
Term
What are the therapeutic objectives when treating Paroxysmal AV nodal reentry?
Definition
1. break the reentry circuit (NSR)
2. Prevent recurrence
Term
What is the choice drug for immediately treating paroxysmal AV nodal reentry?
Definition
Adenosine 6mg IV, 12mg IV, 12mg IV
Term
When treating paroxysmal AV nodal reentry with adenosine some concerning pt variables are...
Definition
Asthma - b/c of broncho-constriction
Term
What is the antidote to adenosine?
Definition
Aminophylline
Term
T/F Massaging the carotid arteries could treat paroxsymal AV nodal reentry?
Definition
True - increases vagal tone, slows HR, resolves problem
Term
What are the choice drugs for chronically treating paroxysmal AV nodal reentry?
Definition
Verapamil, diltiazem, metoprolol
Term
When a pt is in atrial flutter what two problems exist?
Definition
Rhythm control
Rate control
Term
What is the best way to resolve the rate control problem in atrial flutter?
Definition
BB, CCB,Dig...
Term
What is the best way to resolve the rhythm control problem in atrial flutter?
Definition
electrocardioversion
Term
What is the definition of atrial fibrillation?
Definition
supraventricular
tachycardia
disorganized atrial excitation
uncoordinated atrial contraction
erratic ventricular response
Term
3 classes of A. Fib
Definition
1. New-onset
2. Paroxysmal - self terminating w/in 7d
3. Permanent - not self terminating
Term
Describe an EKG of a pt with A. Fib
Definition
No p waves
Term
When controlling rate in a. fib, at what site do BB, CCB, or Dig work at?
Definition
AV NODE
Term
Is rate control better than rhythm control in an a. fib pt
Definition
NO difference AFFIRM, HOT-CAFE, RACE trials
Term
Aside from cardioversion, what other ways are available to correct rhythm in a. fib?
Definition
Catheter-based pulmonary vein ablation
Term
A. fib treatment algorithm (assume the a. fib. is not new-onset)
Definition
1. TEE (trans esophageal echo)

2. If thrombus present than anticoagulates for 3 weeks

3. When/if thrombus free - Cardioversion

4. 4 weeks of anticoagulants
Term
Rate control BPM objectives?
Definition
60-80 @ rest
90-155 @ moderate exercise
Term
The RACE trial...
Definition
Kept pts at strict rate control, and they died. This resulted in a new goal of <110 BPM
Term
T/F BB used to treat arrhythmias should have ISA properties
Definition
False - thus we use esmolol, metoprolol, propranolol
Term
Which CCB is better at sinus rate control, and which CCB is commonly used for AV node rate control`
Definition
Diltiazem - it is better at sinus node control as opposed to av node, but it is much easier to give than verapamil, so everyone uses diltazem IV
Term
When does digoxin work
Definition
@ rest
Term
In what way is therapeutic efficacy determined in digoxin pts?
Definition
Dig levels are irrelevant in terms of therapeutic efficacy…it will be higher than this number b/c you need more to decrease conduction through the AV node than you do for myocardial contractility


Therapeutic efficacy is determined by ventricular rate?
Term
The most important objective in a. fib. pts is...
Definition
Preventing TE stroke
Term
In relation to cardioversion...Most TEs occur...
Definition
w/in 72 hours
Term
]An a. fib. pts long term need for anti-coagulation therapy will be determined by...
Definition
The CHADs scale/chart
Term
The most common drug used in rhythm control at a hospital is
Definition
dofetilide PO

ibutilide IV
Term
T/F a pt must be hospitalized to start dofetilide for rhythm control?
Definition
True
Term
The most common drug used in a. fib. rhythm control is...
Definition
Amiodarone
Term
Half life of amioderone
Definition
40-55 days!!!!
Term
Amiodorone monitoring/counseling points
Definition
1. turn blue in the sun
2. corneal deposits
3. 40% iodine
4. nausea common
Term
Which two drugs are reserved for pts with normal hearts anf a. fib?
Definition
flecainide (150-300mg) & propafenone (600mg)
Term
The CAST study determined...
Definition
PVCs were not such a big deal b/c of pt death, and reduced the use of Clkass 1C drugs
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