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Respiratory Tumors
Respiratory Tumors
14
Biology
11th Grade
05/24/2012

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Term
Poorly differentiated small cells
Arise from neuroendocrine cells
Chromogrannin positive
Definition
Small cell carcinoma

Arise from (Kulchitsky) cells
Term
Associated with smoking
Centrally located
May produce ACTH
Definition
Small cell carcinoma

Chromogrannin positive
Term
May produce ADH, ACTH, or cause Eaton Lambert Syndrome
Definition
Small cell carcinoma
Term
Keratin pearls
Intracellular bridging
Definition
Squamous cell carcinoma
Term
Associated with smoking
Centrally located
May produce PTHrP
Definition
Squamous cell carcinoma
Term
Most common tumor in nonsmokers and female smokers
Glands or mucin seen on histology
Definition
Adenocarcinoma
Term
Peripherally located
May involve the pleura
Definition
Adenocarcinoma

Most common tumor in nonsmokers and in female smokers
Term
Poorly differentiated
No keratin pearls, no intercellular bridges, no mucin or glands seen
Definition
Large Cell Carcinoma

Poor prognosis
Term
Columnar cells that grow along preexisting bronchioles and alveoli

Arise from Clara cells
Definition
Branchioalveloar carcinoma
Term
Not related to smoking
Peripherally located
Presents with a pneumonia like consolidation
Definition
Bronchioalveolar carcinoma
Term
Well differentiated neuroendocrine cells
Chromogrannin positive
Definition
Carcinoid tumor
Term
Presents as a polyp like mass in the bronchus
Grows in cellular nest like distribution
Definition
Carcinoid tumor
Term
Most common organs that metastasize TO the lung
Definition
Breast and colon

The lung likes to metastasize to the adrenals too
Term
Presents as cannon ball nodules on imaging
Definition
Metastasis to lung
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