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Respiratory Histology
Histology 1
54
Medical
Graduate
11/22/2008

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Cards

Term

Place these in the order that air passes through them:

Larynx, Nasal Cavities, Terminal Bronchioles, Alveolar Sacs, Nasopharynx, Alveoli, bronchioles, trachea, oropharynx, bronchi, respiratoy bronchioles, alveolar ducts

Definition
nasal cavities, nasopharynx, oropharynx, larynx, trachea, brinchi, bronchioles, terminal bronchioles, respiratory bronchioles, alveolar ducts, alveolar sacs, alveoli
Term
Where does the respiratory portion of the system begin?
Definition
Respiratory bronchioles
Term
What are the three parts of the nasal cavity?
Definition
Vestibule, Respiratory Segment, Olfactory Segment
Term
what are the bony shelves projecting from the vestibule of the nasal cavity? What is their function?
Definition

nasal conchae (aka turbinates)

 

They create turbulence, which circulates the air to warm, moisten and clean it

Term
What type of epithelium is respiratory epithelium?
Definition
ciliated pseudostratified columnar epithelium with goblet cells
Term
What are the 5 cell types of respiratory epithelium?
Definition

1) Ciliated Columnar

2) Mucous Goblet Cells

3) Brush Cells

4) Basal Cells (stem cells)

5) Small Granule Cells

Term
What structures are located at the apical side of the brush cells?
Definition
Microvilli
(actin-based projections.  Unlike the Ciliated columnar cells, which contain microtubule-based cilia)
Term

What is the job of the basal cells in respiratory epithelium?

Definition
To differentiate into the other 4 cell types
Term
What do Small Granule Cells secrete?
Definition
bombesin and serotonin
Term
What is the function of bombesin and serotonin?
Definition
to control the functioning of other respiratory cells
Term
What is the benefit to the many capillaries found in the conducting portion of the respiratory system?
Definition
Release heat, thereby warming the air
Term
What is Kartagener's Syndrome?
Definition

also known as 'immotil cilia syndrome', it is an inherited condition in which cilia fail to function normally due to a lack of dynein.  Airways are improperly cleared and the individual is more susceptible to bacterial infection.

Term
What cell types are found in Olfactory Epithelium?
Definition

1) Olfactory Receptor Cells (neurons)

2) Supporting (sustentacular) cells

3) Basal Cells (stem cells)

Term
What type of epithelium is Olfactory Epithelium
Definition

pseudostratified columnar epithelium

Term

Are most odorants organic or inorganic compounds?

Definition
Organic
Term
What happens to olfactory neurons after 1 month?
Definition
They are degraded and replaced by newly differentiated basal cells
Term
What type of neuron is an olfactory neuron?
1) Pseudounipolar
2) Bipolar
3) Multipolar
Definition
Bipolar


(special senses contain bipolar neurons)
Term
Why is the nose a particularly susceptible place on the human body?
Definition
It is the only region where neurons have direct contact with the outside environment.  These olfactory neurons provide a passageway/tract from the outside environment directly to the brain.
Term
What are Bowman's Glands?  Where are they located?
Definition
Serous-secreting glands located beneath the olfactory epithelium
Term
How does the nose prepare itself to receive a new smell?
Definition
Bowman's glands secrete a serous fluid, which washes away previous odorant and readies the olfactory neurons to receive a new stimulant.
Term
How many different olfactory receptor types can an olfactory neuron produce?
Definition
1
Term
How do olfactory receptors operate?
Definition
They bind a ligand, which stimulates them to act on ion channels. These ion channels open, depolarizing the cell and inducing an action potential.
Term
What are Mitral cells?  Whare are they located?
Definition
Mitral Cells are neurons located in the glomeruli of the olfactory bulb.  They synapse with olfactory neurons and project their axons into the olfactory tract and ultimately to the olfactory cortex
Term
What causes the pharynx to be so susceptible during an allergic reaction?
Definition

Its high content of mast cells release histamine, causing vasodilation and increased blood flow. This can result in edema, which swells the pharynx and occludes the airway.

 

in severe cases, this can be life-threatening

Term
What type of epithelium lines:
1) nasopharynx
2)orophanynx
3)laryngeal pharynx
Definition

1) respiratory epithelium

2) Stratified Squamous

3) Stratified Squamous

Term
What type of cartilage is found in the epiglottis?
Definition

Elastic Cartilage

Term
What separates the false and true vocal folds?
Definition

laryngeal ventricle

Term
False vocal cords are movable or immovable?
Definition
immovable
Term
Is vocal cord adduction or abduction responsible for phonation?
Definition

adduction. 

 

vocal cords are pulled toward each other by the vocalis muscle, which attaches to the vocal ligament.

Term
What epithelium is found in true vocal cords?
Definition
stratified squamous
Term
what epithelium is found in the false vocal cords?
Definition

Respiratory Epithelium

 

 

(ciliated pseudostratified columnar w/ goblet cells)

Term
If you find stratified squamous cells in the respiratory epithelium, this is an example of what?
Definition
dysplasia
Term
What are the C-shaped rings in the trachea made from?
Definition
hyaline cartilage
Term
What are the 3 layers of the trachea?
Definition

Mucosa
Submucosa

Adventitia

Term
What immune cells are found in the lamina propria of the thracheal mucosa.
Definition
lymphocytes
Term
In what tracheal layer are the c-rings found?
Definition
Adventitia
Term
What happens to the glands, goblet cells, and height of epithelial cells as you preogress down the airways?
Definition
decrease
Term
What happens to smooth muscle and elastic tissue as you progress down the airways?
Definition
Increase
Term
Which bronchi is something more likely to become lodged in?
Definition
Right
Term
What distinguishes bronchi from bronchioles?
Definition
Bronchioles do not have cartilage associated with them
Term
What treatments are used for asthma?
Definition

Steroids and B2-agonists

(relax bronchial smooth muscle)

Term
Where are Clara Cells found?
Definition
Epithelium of terminal bronchioles
Term
What is the function of Clara Cells?
Definition

secrete GAGs, which lubricates the lumen of terminal bronchioles, preventing adhesion of pollutants.

 

Contain smooth ER and produce cytochrome P450 to metabolize airborn toxins

Term
What structural difference can be observed to distinguish respiratory bronchioles from terminal bronchioles?
Definition
Breaks in the wall are visible in respiratory bronchioles.  These lead into alveolar outpocketings.
Term

What structural feature can be seen in alveolar ducts, but not alveolar sacs?

Definition
muscle nodules
Term
What are lamellar bodies?
Definition
secretory organelles of type II pneumocytes, which contain surfactant
Term
Which alveolar cell secretes surfactant
Definition
type II
Term
what is the respiratory treatment for a premature baby?
Definition
synthetic surfactant and glucocorticoids
Term
what comprises the blood-air barrier?
Definition

1) alveolar epithelial cells

2) basal lamina of alveolar epithelium
3) basal lamina of capillaries

4) endothelial cells of capillaries

Term
what are macrophages in the alvoleolar region known as?
Definition
dust cells
Term
What do alveolar pores of Kohn do?
Definition
equalize pressure between alveoli
Term
Cigarette smoking is the major cause of emphysema.  How does this lung disease decrease the O2 absorption in the lungs?
Definition
destruction or impaired synthesis of elastic fibers leads to fewer and larger alveoli with less total surface area.  This decreases O2 absorption efficiency.
Term

What are 2 examples of Chronic Obstructive Pulmonary Disease (COPD)?

Definition
Bronchitis
Emphysema
Term
How does bronchitis cause breathing difficulties?
Definition
constriction of the bronchiole smooth muscles
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