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Resp drugs
step I
21
Medical
Graduate
05/13/2009

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Cards

Term
diphendramine
Definition
first generation h1 blocker. Mechanism: reversible inhibition of histamine receptors. uses: allergy, motion sickness, sleep aid. tx: sedation, antimuscarinic (hence the sleepy), motion sickness
Term
dimehydrinate
Definition
first generation h1 blocker. Mechanism: reversible inhibition of histamine receptors. uses: allergy, motion sickness, sleep aid. tx: sedation, antimuscarinic (hence the sleepy), motion sickness
Term
cholorpheniramine
Definition
first generation h1 blocker. Mechanism: reversible inhibition of histamine receptors. uses: allergy, motion sickness, sleep aid. tx: sedation, antimuscarinic (hence the sleepy), motion sickness
Term
cholorpheniramine
Definition
first generation h1 blocker. Mechanism: reversible inhibition of histamine receptors. uses: allergy, motion sickness, sleep aid. tx: sedation, antimuscarinic (hence the sleepy), motion sickness
Term
cholorpheniramine
Definition
first generation h1 blocker. Mechanism: reversible inhibition of histamine receptors. uses: allergy, motion sickness, sleep aid. tx: sedation, antimuscarinic (hence the sleepy), motion sickness
Term
loratadine
Definition
2n generation histamine blockers, has less entry into CNS so is far less edating. used for allergy (claritan)
Term
fexofenadine
Definition
2n generation histamine blockers, has less entry into CNS so is far less edating. used for allergy (claritan)
Term
desloratadine
Definition
2n generation histamine blockers, has less entry into CNS so is far less edating. used for allergy (claritan)
Term
cetrizine
Definition
2n generation histamine blockers, has less entry into CNS so is far less edating. used for allergy (claritan)
Term
Isoproterenol
Definition
non selective Beta agonist acts on AC to increase cAMP. causes Tachycardia (b1) and broncho dialation (b2)
Term
albuterol
Definition
B2 agonist relaxes bronchial smooth muscle. adverse effects are tremor and arrhythmia.
Term
salmetrol
Definition
B2 agonist relaxes bronchial smooth muscle. adverse effects are tremor and arrhythmia.
Term
Theophylline
Definition
likely causes bronchodilation by inhibiting phosophodiesterase thereby reducing cAMP hydrolysis (therby increaseing cAMP's ability to dilate. usage is limited by narrow theraputic index. metabolized by P-450
Term
Ipratropium
Definition
competitive block of muscarinic receptors preventing, bronchoconstriction. also used for copd.
Term
cromolyn
Definition
prevents released of mediators from mast cells, effective only for prophylaxis of asthma not effective during acute a attack. toxcity is rare.
Term
Beclotmethasone
Definition
inhibits the synth of all cytokines. inactivates nf-kb, the transription that induces the production of TNF-a and other inflammatory agents. 1st line for chronic asthma. obviously a host of catabolic effects.
Term
Zileuton
Definition
5-lipoxgenase pathway inhibitor, blocks conversion of arachadionic acid to leiotrienes
Term
Zafirlukast
Definition
blocks leukotrienes receptors, especially good for asprin induced asthma
Term
montelukast
Definition
blocks leukotrienes receptors, especially good for asprin induced asthma
Term
guaifensein (robotussin)
Definition
exportant: reomves excess sputum, but large doses necessary. does not supress cough reflex.
Term
N-acetylcysteine
Definition
mucolytic= can loosen mucous plugs in CF patients. cleaves disulfide bonds within mucous glycoproteins. also used as an antidote for acetaminophen overdose.
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