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RES 136 Chapter 1
RES 136 Chapter 1
148
Medical
Undergraduate 3
10/20/2011

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Term
URT composition
Definition

 nasal cavity and sinuses

oral cavity

pharynx

larynx

Term
Where does gas exchange occur?
Definition
LRT
Term
what does the eustachian tube do?
Definition
leads to ear canal, allows to equalize pressure
Term
where do the external nares lead into?
Definition
into the cavities
Term
what are the vestibules?
Definition
rt and lft chambers in the opening of the nose (contain vibrissae hairs as a filter)
Term
There are 3 shelf-like bones projecting as lateral walls. what are they called?
Definition
concha or turbinates
Term
what are the functions of the concha/turbinates?
Definition
increase surface area for filtering, warming and humidifying of inhaled gases
Term
function of the meatus
Definition
drains mucus from sinus cavities (below the concha)
Term
olfactory cells do what?
Definition
provide sense of smell
Term
how do the cavities and sinuses obtain surface fluid?
Definition
provided by the goblet cells and submucosal glands
Term
what seperates the nasal from the oral cavity?
Definition
palatine process of the maxilla
Term
which epithelium layer lines the oral cavity, larynx, and anterior 1/3 nasal cavity?
Definition
stratified squamous
Term
which epithelium contributes to the trachea and bronchioles and latter 2/3 of nose (where you see mucus)?
Definition
psuedostratified columnar ciliated epithelium
Term
what layers are in the simple cuboidal epithelium?
Definition
respiratory bronchioles to terminal bronchioles
Term
which set of airways are are before the alveoli?
Definition
respi and terminal bronchioles are last sets before aveoli
Term
how thick is the simple squamous epithelium?
Definition
one cell thick
Term
what epithelium layer contains the alveoli and capillaries?
Definition
simple squamous epithelium
Term
4 sets of sinuses?
Definition

frontal

ethmoid

sphenoid

maxillary

Term
functions of the sinuses?
Definition

reduce weight of head

strengthen skull

modify the voice during phonation

produces mucus

Term
an infection can affect mucus how?
Definition
produce more mucus and in turn become trapped due to swelling
Term
what portion of the tongue has a gag reflex to protect the airway?
Definition
posterior (taste buds)
Term
aspiration will lead to what?
Definition
an infection
Term
tonsils are made of what type of tissue?
Definition
lymphoid
Term
funtion of the tonsils and 3 types?
Definition
immunologic defense; pharyngeal, palatine, lingual
Term
where are the pharyngeal, palatine, and lingual tonsils located?
Definition

phary- nasopharynx (adenoids)

pala- oral cavity

ling- base of tongue

Term
where does the laryngopharynx lie behind?
Definition
the epiglottis
Term
muscular membranes act as a source of what?
Definition
conduction
Term
3 portions of the pharynx
Definition

nasopharynx

oropharynx

laryngopharynx

Term
nasopharynx consists of what?
Definition

eustachian tube opening to ears

pharyngeal tonsils

Term
the oropharynx consists of what (from uvula to tip of epiglottis)?
Definition

palatine tonsils

lingual tonsils

vallucula

Term
where specifically is the vallecula located?
Definition
space between the wall of pharynx and epiglottis
Term
which pharynx and nerves produce the gag reflex?
Definition
laryngopharynx; sensory 9th cranial nerve ( glossopharyngeal) and motor 10th cranial nerve (vagus)
Term
is the pharynx soft or hard tissue?
Definition
soft
Term
relative positions of oral cavity, pharynx, and larynx are major determinants of what?
Definition
patency, particularly in an unconscious patient
Term
what in the airway can occur if the patient's head tilts forward?
Definition
partial or total occlusion
Term
what position should the head be in to open the airway and facilitate artificial airway insertion?
Definition
"sniff position"
Term
in the process of oral intubation, what type of tube will be used?
Definition
endotracheal tube
Term
functions of the larynx:
Definition

acts as a pathway

protective mechanism against aspiration

speech (vocal cords)

Term
what is the normal structure of a larynx?
Definition

9 cartilages

single: thyroid, cricoid, epiglottis

paired: arytenoid, corniculate, cuneiform

vocal cords

glottis

Term
where is the adam's apple located?
Definition
thyroid cartilage
Term
what are some symptoms of croup?
Definition

drooling

barking cough

swollen epiglottis

swollen trachea tissue below the vocal cords

Term
what is the ventilatory function of the larynx?
Definition
abduct/adduct of the vocal cords with inspiration and expiration
Term
what is the valsalva manuever?
Definition
pushing up against the vocal cords will stimulate a vagal response; tachycardic pt take laxatives to not stimulate the vagus
Term
lower airways begin with what structure?
Definition
trachea
Term
the conducting zone is known as what?
Definition
dead space
Term
how are generations in the structures of the lungs divided?
Definition
divided in each section of the LRT
Term
what do goblet cells do?
Definition
produce a gel layer within the epitheial lining
Term
the submucosal/bronchial glands are parasympathetic innervated and produce how many ml of mucus/day?
Definition
100 ml
Term
the lamina propia contains what?
Definition
bld vessels, vagus nerve endings, smooth muscle fibers, and mast cells
Term
the epitheial lining consists of:
Definition

basement membrane

basal cells

goblet cells

submucosal/bronchial glands

lamina proopia

psuedostratified ciliates columnar epithelium

Term
mucus contains two layers:
Definition

sol layer

gel layer

Term
characteristics of sol layer of mucus
Definition

thin secretions

adjacent to the cilia

Term
gel layer characteristics
Definition

viscous

close to interluminal surface

Term
2 types of immune response
Definition

cellular immunity

humoral immunity

Term
cellular immunity
Definition
sensitized lymphocytes responsible for tissue rejection
Term
humoral immunity
Definition
circulating antibodies also known as immunoglobins which defend against circulating antigens
Term
types of circulating antibodies
Definition
lgA, lgG, lgM, lgD, and lgE
Term
mast cells contain what?
Definition
chemical mediators of inflammation
Term
types of chemical mediators:
Definition
histamine, heparin, leukotrienes, platelet-activating factor (PAF), slow reacting substance of anaphylaxis (SRS-A), eosinophillis cemotactic factor of anaphylaxis (ECF-A)
Term
What is the chain reaction of antigen exposure?
Definition

antigen exposure

specific lgE release

lgE attaches to mast cell

second exposure

lgE interaction ruptures mast cell

chemical mediators released

Term
immunologic mechanisms results in:
Definition

increased vascular permeability

smooth muscle contraction

increased mucus production

vasodilation with edema

Term
order of the structure of the lungs
Definition

trachea

L & R main bronchi (lungs)

lobar bronchi (lobes 3R, 2L)

segmental bronchi (bronchopulmonary segments)

bronchioles

terminal bronchioles

resp. bronchioles

alveolar ducts

alveolar sacs

alveoli

Term
the trachea extends below the cricoid cartilage to sternal angle and has the length and diameter of what?
Definition
11-13cm in length and 1.5-2.5cm diameter
Term
trachea has how many c-shaped cartilages?
Definition
15-20
Term
what connects the c-shaped cartilage and forms the posterior wall in the trachea?
Definition
muscle
Term
true of false. the carnia has A LOT of nerve endings.
Definition
true
Term
rt and lft mainstem bronchi bifurcate at what?
Definition
carina
Term
rt bronchus branches at a 20-30 degree angle. due to this angle, what happens?
Definition
due to this angle, most foreign aspirate goes to the rt lower lobe
Term
what angle does the lft branches sit at?
Definition
45-55 degrees
Term
what is the number of lobes and segments for the lft and rt lungs?
Definition

rt- 3 lobes, 10 segments

lft- 2 lobes and 8 or 10 segments

Term
true or false. each segment is supplied by a segmental bronchus and further divides numerous times until the conduction airways end in terminal bronchioles.
Definition
true
Term
true or false. all airways up to the terminal bronchioles constitute anatomical dead space.
Definition
true
Term
acinus
Definition
bronchioles, alveoli sacs and ducts
Term
resp broncioles have two functions:
Definition

conduct gas deeper into resp zone

participate in gas exchange (bronciole walls sprout alveolis)

Term
each acinus is composed of:
Definition
resp bronchioles, alveolar ducts, alveolar sacs, and about 10,000 alveoli
Term
alveoli
Definition
saclike growths that sprout on walls on resp bronchioles, alveolar ducts and alveolar sacs; primary function is gas exchange
Term
characteristics of type 1 pneumocytes
Definition
flat, cover 93% alveolar surface, thin, tight joints
Term
function of type 1 pneomocytes
Definition
faciliatate gas exchange in alveoli, limit movements of materials into alveolar space
Term
characteristics of type 2 pneumocytes
Definition
cuboidal, twice as many as type 1 pneumoncytes, smaller, make up the cell wall
Term
functions of type 2 pneumocytes
Definition
produces surfactant, store surfactant, keep alveoli from collapsing by reducing surface tension, increases compliance and decreases work of breathing
Term
function of alveolar macrophages
Definition
provide defense; can move around, full of potent enzymes, destroy foreign cells
Term
what types of pneumocytes are in the acinus?
Definition
type 1, type 2, and free alveolar macrophages
Term
canals of lambert
Definition
little openings in bronchioles (tubes) where gas can exchange
Term
4 main components of the pulmonary vascular system
Definition

arteries

arterioles

capillaries

venules and veins

Term
true or false. veins return to the heart and arteries leave the heart
Definition
true
Term
what do the bronchial arteries supply bld to?
Definition
tracheal bronchial tree, mediastinal lymph nodes, pulmonary nerves, esophagus, and visceral pleura
Term
true or false. bronchial arteries have 99% cardiac output and eventually merge with the pulmonary arteries and capillaries
Definition
false. they have a 1% output
Term
describe how, how much, and where the bronchial veins supply bld to in the heart.
Definition

by way of azygos, hemiazygos and intercostal veins, 1/3 return to rt atrium

 

by way of bronchiopulmonary anastomos, 2/3 return to the lft atrium

Term
lympathic system has 3 main components to it:
Definition
lymphatic vessels, lymph nodes, juxta-alveolar lymphatics
Term
juxta-alveolar lymphatics
Definition
vessels immediately adjacent to alveoli
Term
lymph nodes function
Definition

produce lymphocytes and monocytes

filter bacteria

Term
function and distribution of the lymphatic vessels
Definition

function: remove excess fluid from the lungs

distribution: more lower lobes, lft lower lobes more than right lower lobes

Term
true or false. the apex of the lung pointed, rises above the level of the 1st rib.
Definition
true
Term
the base of the lung convex lies where in relation to the ribs?
Definition
6th rib anterior, 11th rib posterior
Term
characteristics of the rt lung
Definition
larger, heavier, 3 lobes, 2 fissures, olbique and horizontal
Term
characteristics of the lft lung
Definition
smaller, 2 lobes, 1 fissure, oblique
Term
where is the mediastinum located and what organs does it contain?
Definition
between the rt and lft lungs; contains the heart, great vessels of the heart, esophagus, trachea, phrenic nerve, cardiac nerve, thoracic duct, and lymph nodes of the central chest
Term
what is included in the anterior sternum area?
Definition
manubrium, body of sternum (gladiolus), xiphoid process
Term
where is the posterior thoracic vertebrae located?
Definition
between the cervical and lumbar regions; increase in size as proceed down the spine
Term
carnia
Definition
the site of the tracheal bifurcation at the lower end of the trachea
Term
angle of louis
Definition
where the manubrium attaches to the body of sternum
Term
where is the carnia located?
Definition
at the 4th to 5th thoracic vertebrae, which is the angle of louis
Term
true or false. the mucous membrane of the carnia is the most sensitive area of the trachea and larynx for triggering a cough reflex
Definition
true.
Term
hilum
Definition
a triangular depression where the structures which form the root of the lung enter and leave
Term
what forms the thoracic wall?
Definition
skin, fat, skeletal muscles, bony structures
Term
parietal pleural
Definition
inner layer lined with serous membrane
Term
visceral pleura
Definition
contacts the serous membrane that covers the lungs
Term
pleural space
Definition
thin fluid layer seperating pleuras
Term
the parietal and visceral pleuras are filled with how much fluid?
Definition
approx 10 ml fluid
Term
what does the pleural fluid do?
Definition
decreases lung friction as lungs slide accross the inner chest wall
Term
is pleural pressure positive or negative?
Definition
negative due to opposing tendency of lung to collapse and thorax to expand
Term
costophrenic angle
Definition
formed where parietal and pleural departs chest wall to diaphragm
Term
pairs 1-7 (true ribs) of the ribs connect to what?
Definition
directly to the sternum
Term
how many pairs of ribs are there?
Definition
12 pairs
Term
immediately below each rib lies what?
Definition
artery, vein, and nerves for that portion of the chest wall
Term
8-10 rib pairs are called what, 11th and 12th are called what?
Definition

8-10 are called false ribs

11-12 called floating ribs

Term
the diaphragm seperates what?
Definition
the thoracic cavity (heart, lungs and ribs) from the abdominal cavity
Term
true or false. the diaphragm functions in breathing
Definition
true
Term
nonrespiratory functions of the diaphragm:
Definition

expel vomit, feces, urine by increasing intra-abdominal pressure

prevents acid reflux by exerting pressure on the esophagus as it passes through the hiatus

Term
what are the primary muscles of respiration?
Definition
diaphragm and intercostals
Term
diaphragm and intercostals characteristics:
Definition

active during resting breathing

75% of work performed by diaphragm

muscle relaxation results in passive exhalation

Term
characteristics of accessory muscles of inspiration:
Definition

active only during increased demand

primarily scalene and sternocleidomastoids

Term
accessory muscles of inspiration include what?
Definition

scalenus muscles

sternoclidomastoid muscles

pectoralis major muscles

trapexius muscles

external intercostal muscles

Term
during times of increased demand, expiratory muscle contraction increases what?
Definition
speed of exhalation
Term
what is the process of expiratory muscle contraction?
Definition

*compression of abdomen by an array of abdominal muscles

*ribs pulled down and together by internal intercostal muscles

Term
accessory muscles of expiration
Definition

rectus abdominus

external abdominus obliquus

internal abdominus obliquus

transversus abdominis

internal intercostal muscles

Term
the heart is composed of 3 layers:
Definition

outer is epicardium

middle myocardium

endocardium

Term
middle myocardium
Definition
comprises the bulk of the heart and is composed of muscle tissue
Term
endocardium
Definition
forms a thin continuous tissue with bld vessels
Term
4 muscle chambers of the heart
Definition

upper chambers- rt and lt atria

lower chambers- rt and lt ventricles (responsible for forward movement of the bld)

Term
semilunar valves consist of how many half-moon shaped cuffs?
Definition
3
Term
what are the 2 semilunar valve types and where are the semilunar valves located?
Definition
pulmonary valve and aortic vavle;ventricle exits to arterial trunks
Term
where is the pulmonary valve located?
Definition
between the rt ventricle and the pulmonary artery
Term
where does the aortic valve lie between?
Definition
between the lft ventricle and aorta
Term
during systole, what happens?
Definition
valves open, allowing the ventricular ejection into arteries (pulmonary artery and aorta)
Term
during diastole, what happens?
Definition
the valves close, preventing back flow of bld into the ventricle
Term
the rt and lft coronary arteries arise behind the aortic valve cusps. what happens with the coronary arteries during systole and diastole?
Definition

sys- cusps obstruct flow into the system

dia- bld flow occurs so this pressure is very important

Term
systemic venous bld returns to the rt atrium via:
Definition
superior (drains upper extremities) and inferior (drains lower body) vena cava
Term
bld flows through the tricuspid valve into which ventricle?
Definition
right ventricle
Term
pumped from the right ventricle through the pulm. valve into the pulm. artery carries bld where?
Definition
to the lungs (called oxygenation)
Term
pulmonary arterial bld returns by the pulmonary veins to which atriumm?
Definition
lft atrium
Term
from the lft atrium, oxygenated bld flows through the mitral valve into which ventricle?
Definition
lft ventricle
Term
true or false. lft ventricle pumps the bld out through the aortic valve and into systemic circulation.
Definition
true
Term
bld passes through the systemic capillary beds into the systemic veins and back to where?
Definition
the svc and ivc
Term
systemic vasculature has 3 components
Definition

arterial system- large elastic resistance, small muscular arterioles like faucets

capillary system- transfer nutrients and waste products

venous system- reservoir for circ. system holds 3/4 of bodys bld volume

Term
true or false. A/C membrane provides area for gas exchange.
Definition
true. 140 m2 and 1um thick
Term
O2 and CO2 diffuse from the alveoli through what?
Definition

surfactant layer

type 1 cell

basement membrane

plasma

capillary endothelial cells

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