Term
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Definition
| Symptoms include verbal and physical aggression, cruel behavior toward people and pets, destructive behavior, lying, truancy, vandalism, and stealing. |
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Term
| what disorder has symptoms that include verbal and physical aggression, cruel behavior toward people and pets, destructive behavior, lying, truancy, vandalism, and stealing. |
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Definition
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Term
| which 5HT transporter allele is implicated in aggression? (5-HTTLPR) |
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Definition
the short one. this is a study done in rhesis monkeys.
interestingly, low serotonin and high dopamine & NE in the cortex is implicated in aggression, while decreased gaba and increase ACh & glutamate in the limbic lobe is. |
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Term
| Low MAOA activity is important because |
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Definition
| it can lead to aggression in BOYS that were ABUSED |
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Term
| the frontostraital regions have been implicated in which disorder? (noradrenergic, adrenergic, dopaminergic) |
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Definition
ADHD. decreased levels in NE & dopamine
gaba may also be involved |
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Term
| in ADHD, dysregulation of _______ inhibitory activity (mostly _____ergic) to _______ (predominantly ______ergic) leads to deficits in _____ inhibition and ______ function. |
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Definition
| frontocortical; noradrenergic; striatal; dopaminergic; response inhibition; executive function |
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Term
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Definition
| alpha2 agonist. it is used for ADHD. it is good for controlling impulsivity and inattention, but is debatable for hyperactivity. |
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Term
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Definition
| alpha2 agonist. it is used for ADHD. it is good for controlling impulsivity and inattention, but is debatable for hyperactivity. |
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Term
| what two drugs are alpha2 agonist. they are used for ADHD, and are good for controlling impulsivity and inattention, but efficacy is debatable for hyperactivity. |
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Definition
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Term
| what antidepressants can be used for ADHD? |
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Definition
IMIPRAMINE (TCA, can be used for enuresis, although desmopressin(synthetic vasopressin) is the DOC for this condition)
BUPROPION (weak dopamine/NE reuptake inhibitor. also used for smoking cessation; seizures in bulimic patients. no sexual side effects. metabolized by CYP2D6)
ATOMOXETINE (blocks NE reuptake (unlike methylphenidate which is a dopamine RI); non-stimulant; do not give to patients on MAOIs; do not give people with narrow-angle glaucoma; |
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Term
| give the actions behind imipramine, bupropion, and atomoxetine. what do these three drugs have in common? |
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Definition
IMIPRAMINE (TCA, can be used for enuresis, although desmopressin(synthetic vasopressin) is the DOC for this condition)
BUPROPION (weak dopamine/NE reuptake inhibitor. also used for smoking cessation; seizures in bulimic patients. no sexual side effects. metabolized by CYP2D6)
ATOMOXETINE (blocks NE reuptake (unlike methylphenidate which is a dopamine RI); non-stimulant; do not give to patients on MAOIs; do not give people with narrow-angle glaucoma;
all three of these drugs are used to treat ADHD |
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Term
| how does methyphenidate work? |
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Definition
| blocks dopamine reuptake (dopamine is thought to be low in ADHD-->disregulation of inhibitory input from frontocortical area to striatal dopiminergic areas decrease response inhibition and executive funciton) |
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Term
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Definition
| going on forever in detail (psychosis symptom) |
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Term
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Definition
| someone trying to tell you something in a strange way "somebody left that chair there to tell me to park in the garage" (psychosis) |
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Term
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Definition
| people giving you messages through the radio (psychosis) |
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Term
| five a's of negative symptoms of psychosis |
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Definition
affective flattening
alogia - reduction in fluency, productivity of thought and speech
avolition - restriction in goal directed behavior
anhedonia
attention impairment |
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Term
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Definition
| reduction in fluency and productivity of thought and speech (psychosis) |
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Term
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Definition
| reduction of initiation of goal-directed behavior |
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Term
| what do you use to block the EPS of D2 antagonist AP drugs? |
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Definition
| anticholinergics. Diphenhydramine and benztropin |
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Term
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Definition
| anticholinergic (used with first line AP and antiparkinsonian drugs to prevent EPS) |
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Term
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Definition
| anticholinergic. used with first line AP to prevent EPS |
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