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Radiobiology ch 29-36
Hawkes
132
Biology
Undergraduate 1
01/24/2018

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Term
Describes SEVERITY of radiation response; you can determine what will happen.

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Definition
Deterministic
Term
INCIDENT of the radiation response increases with increasing dose

Long term effects
Definition
Stochastic
Term
water makes up ___% of the body
Definition
80%
Term
Which molecular composition of the body is most radio-sensitive?
Definition
DNA (nucleic acid)
Term
When are cells most vulnerable?
Definition
division
Term
Radiation doses that are "protracted" are given _________?
Definition
continously
Term
Radiation doses that are "fractionated" are given _________?
Definition
with breaks in between
Term
What type of graphs are A, B, and C?
[image]
Definition
A. linear, non-threshold
B. linear, threshold
C. non-linear, threshold
Term
What does LET stand for?
Definition
Linear Energy Transfer
Term
At what rate does an alphaparticle use energy?
Definition
QUICKLY! High LET

(Like how a monster truck uses up it's gas fast)
Term
What does LET stand for?
Definition
Linear Energy Transfer
Term
At what rate does an alphaparticle use energy?
Definition
QUICKLY! High LET

(Like how a monster truck uses up it's gas fast)
Term
At what rate does an xray photon use energy?
Definition
slowly; low LET (like a prius that can keep running on it's tank of gas)
Term
What does RBE stand for?
Definition
Relative Biological Effectiveness
Term
what does RBE measure?
Definition
How effective radiation is at affecting biological tissue relative to "test radiation"
Term
How do you solve RBE?
Definition
(Baseline / test radiation) = RBE
Term
AS LET goes up the RBE goes....
Definition
up!
Term
What does OER stand for?
Definition
Oxygen Enhancement Ratio
Term
What do OER measure?
Definition
The ability of oxygen to increase the effectiveness of radiation to damaged tissues.
Term
How do you solve OER?
Definition
(anoxic / aerobic) = OER
Term
SI unit name for roentgen, R (and SI symbol)
Definition
air kerma (GYa)
Term
SI unit name for rad (and SI symbol)
Definition
gray (GY1)
Term
SI unit name for rem (and SI symbol)
Definition
sievert (Sv)
Term
Exposure (ionization in the air) is known as
Definition
roentgen
Term
Absorbed dose is known as
Definition
rad
Term
Effective dose is known as
Definition
rem
Term
R/100=
Definition
GYa
Term
rem/100=
Definition
Sv
Term
RBE will increase with increasing
Definition
LET
Term
All are properties of x-rays except:
- they travel in straight lines, in a predictable, divergent pattern
-can ionize atoms
-capable of producting harmful biological effects
-are affected by magnetic fields
Definition
"are affected by magnetic fields"
Term
As LET continues to increase, the ability of O2 to enhance radiosensivity decreases this is because
Definition
When LET reaches a certain level, the radiation itself will destroy all of the cells. Therefore, O2 no longer has a measurable effect in increasing the effectiveness of the radiation
Term
T or F; X-rays are electrically neutral
Definition
True
Term
The _____ is the basic functional unit of all plants and animals.
Definition
Cell
Term
What are nucleic acids in the cell?
Definition
DNA and RNA
Term
The most radiosensitive target molecule in the human cell is the
Definition
DNA
Term
T or F; Overall, the cells of a typical 25 year old person have the exact same sensitivity cells of a typical 85 year old person
Definition
FALSE
Term
Meiosis is the process of cell division for ____ cells
Definition
genetic
Term
The law of ________ states that the radiosensitivity of living tissue is a function of metabolism and maturation of that tissue.
Definition
Bergonie and Tribondeau
Term
Tissues that are immature with a ____ metabolic rate are more radiosensitive
Definition
high
Term
___ is a measure of the rate that energy is transferred from ionizing radiation to soft tissue
Definition
LET
Term
As LET ______, the RBE ______.
Definition
increases, increases
Term
A protracted dose of radiation is given
Definition
over a long period of time
Term
Tissue is ____ radiosenstive under high oxygen conditions and ____ radiosensitive under hypoxic conditions.
Definition
more, less
Term
humans are most radiosensitive during
Definition
fetal stages
Term
The possible beneficial effect of a small amount of radiation is called
Definition
hormesis
Term
A ____ response to radiation is directly proportional to the dose received.
Definition
Linear
Term
If a response to radiation is expected at a certain dose, then that dose-response is referred to as
Definition
threshold
Term
Radiation induced leukemia follows a _____ response relationship.
Definition
linear, non-threshold
Term
All of the following describe characteristics of radiosensitive cells, except:
a. specialized
b. high mitotic rate
c. undifferentiated
d. stem
Definition
a. specialized
Term
All of the following responses are classified as stochastic, except:
a. cancer
b. radiation induced skin burns (erythema)
c. leukemia
d. genetic effects
Definition
b. radiation induced skin burns (erythema)
Term
As LET increases, OER ______
Definition
decreases
Term
What are the three principles of radiation protection?
Definition
time, distance, and shielding
Term
What does the NCRP establish?
Definition
recommended limits, values, measurements, etc. (DOESN'T ENFORCE)
Term
Who enforces the radiation safety?
Definition
-FDA
-Department of heath, education and welfare
-OSHA
-State Regulatory Boards
Term
The radium watch dial painters showed an increase incidence of
Definition
bone cancer
Term
_____ tissue is most radio-resistant (least radio-sensitive).
Definition
Nervous
Term
immediately following a whole body dose of 10 Gy, the victim would experience _______ symptoms.
Definition
prodromal symptoms
Term
most sensitive cells in the hematopoietic system?
Definition
lymphocytes
Term
During which period does the victim experience a lack of symptoms and seems to feel fine?
Definition
latent period
Term
Gonadal responses to radiation
Definition
.1 Gy
Term
Most effects of x-radiation in macromolecules of living systems in vivo, result from _____ action
Definition
indirect
Term
Cataracts show non-linear, threshold results, what is the effect?
Definition
late effect
Term
Chernobyl Nuclear Disaster increased rate of ______ cancer
Definition
thyroid
Term
6 Gy = ___ RAD
Definition
600
Term
If radiation interacts with a "simple" cell and deactivates the "master molecule" what will most likely happen?
Definition
cell death
Term
How many sieverts is 500 mSv?
Definition
.5 Sv
Term
indirect effects are ____ common
Definition
most
Term
Destruction of ____ cells in intestinal lining is a major contributor to the cause of death from GI syndrome
Definition
stem
Term
main chain scission's effect on viscosity
Definition
reduces viscosity
Term
greater mitotic rate = greater radiosensitivity
Definition
Bergonie and Tribdondeau
Term
Bergonie and Tribdondeau says _____ proportional to reproductive activity and _____ proportional to their degree of specialization
Definition
directly, indirectly
Term
The ionization of water is aka
Definition
radiolysis
Term
OER and LET are _____ proportional
Definition
indirectly
Term
LET and RBE are ______ proportional until maximum is reached.
Definition
directly
Term
______ can be used to increase sensitivity of tumor cells to radiation
Definition
oxygen
Term
The CNS syndrome occurs after whole body dose of ____Gy or more
Definition
50 Gy
Term
50/60 results in death in ___ days, ___% of irradiated population
Definition
60 days, 50%
Term
a person subjected to 50 Gy would most likely survive for about _______ before death occurred
Definition
a few days
Term
the amount of absorber material that will reduce the intensity of the beam to 1/2 of the original
Definition
HVL- Half Value Layer
Term
The ______ barrier is a wall or area where the x-ray tube can never be directed towards.
Definition
secondary (1/32 lead)
Term
The _______ barrier is any wall that the x-ray tube can be directed at
Definition
Primary
Term
The lead equivalence for the primary barrier
Definition
1/16 lead
Term
The x-ray tube is never pointed at the ______ barrier.
Definition
secondary
Term
In fluoro, the _________ acts as a primary protector barrier
Definition
image intensifier
Term
Total filtration when operated above 70kVp
Definition
2.5mm
Term
What is the traditional until for Air Kerma (Gya)
Definition
Roentgen
Term
What is the SI unit for Rad?
Definition
Gray
Term
What is the traditional unit for equivalent and effective dose?
Definition
Rem
Term
D x WR =
Definition
EqD
Term
D x WR x WT =
Definition
EfD
Term
_____ tells a simple story, ____ tells a more complete story and ______ tells the whole story.
Definition
Air Kerma, Gray, and Sievert
Term
To keep time short in fluor what three things should be done?
Definition
-pulsed fluoro
-staggered foot pedal
-don't use mag feature
Term
What is added together to get the total filtration (2.5)?
Definition
inherent (.5) and added (2mm)
Term
How long must the mobile x-ray cord be?
Definition
6 feet (2 meters)
Term
What are the three things control panels must do?
Definition
light up, make a sound and be fixed on the wall.
Term
SID indicator has to be within __%.
Definition
2%
Term
As radiation absorption in biologic tissue increases, the risk of adverse effects also increases.
Definition
True
Term
Gonadal doses as low as _____ Gy can depress sperm count in the male, and delay or suppress menstruation in the female
Definition
.1
Term
Which of the following is not a likely result of radiolysis?
-creation of isotopes within the blood
-formation of H2O2
-formation of free radicals
-re-formation of H20
Definition
creation of isotopes within the blood
Term
Radiation protection guidelines for radiographers are based on:
Definition
stochastic effects of radiation
Term
Which of the following is true regarding the cells/tissues of children?
-because their cells are less specialized and have an increased rate of mitotic activity, adults are less sensitive to radiation than children.
-because of their increased metabolism, children are less radiosensitive than adults
-because of their slower metabolism when compared to adults, children are less sensitive to radiation.
-because of their increased metabolism, children are more sensitive to radiation than adults.
Definition
because of their increased metabolism, children are more sensitive to radiation than adults.
Term
A cell that has a higher rate of mitosis, will be more resistant to radiation than a cell with a slower rate of mitosis
Definition
false
Term
A ______ effect increases in incidence but not in severity as the dose increases.
Definition
stochastic
Term
As radiation absorption in biologic tissue increases, the risk of adverse effects also increases.
Definition
true
Term
x-rays are produced as a result of:
-electrons being driven into the cathode with high kinetic energy
-electrons being driven into the anode with high kinetic energy
-AC current across the x-ray tube
-exciting electrons in an air filled chamber
Definition
electrons being driven into the anode with high kinetic energy
Term
Also known as an indirect effect
Definition
radiolysis
Term
All of the following are possible results of radiolysis except:
-alpha particles are created
-production of free radicals
-H20 recombines to form a normal water molecule
-H202 (hydrogen peroxide) is created
Definition
alpha particles are created
Term
The viscosity of macromolecules irradiated in vitro is decreased when ______________ is observed.
Definition
Main Chain Scission
Term
This type of cancer results in the over-production of white blood cells, and has a linear, non-threshold dose response relationship
Definition
leukemia
Term
Malignant disease (cancer, leukemia) and genetic damage observed in later generations, follow a...
Definition
linear, non-threshold dose response relationship
Term
A "low" D37 dose would indicate:
Definition
radiosensitive cells
Term
The probability of a hit is increased with _______ oxygen and ______ LET radiation.
Definition
high, high
Term
The ______ -target, _______ -hit model of radiation induced cell death applies to simple cells only.
Definition
single, single
Term
Which of the following has the highest LET?
Definition
alpha particle
Term
This can be a result of radiolysis, can damage a cell, and has a greater probability of occurring in the presence of 02
Definition
free radical
Term
Which of the following best describes the term, "HVL?"
Definition
The amount of absorber material that will reduce the intensity of the beam to 1/2 of the original
Term
EqD (equivalent dose), takes into account the dose and
Definition
The radiation weighting factor
Term
Which of the following units would be used to describe a dose, when the type of radiation is known, and the tissues that are irradiated are known:
Gya
C/kg
Roentgen
Sievert
Definition
Sievert
Term
In regards to the x-ray tube housing, leakage must be less than:
Definition
1 mGy/hour at 1 meter from the tube
Term
When testing for linearity (or "reciprocity"), a medical physicist will move the mA and time stations around to ensure the same mAs can still be created. The allowable deviation for linearity is:
Definition
10%
Term
"The exposure switch cord should be at least 2 meters in length." This describes a safety limit for:
Definition
A portable x-ray machine
Term
The minimum SSD (source to skin distance) for a fixed fluoroscopic unit is________, and for a mobile fluoroscopic unit it is _________.
Definition
15", 12"
Term
A primary barrier, must have ________ of Pb, or Pb equivalent.
Definition
1/16"
Term
A secondary barrier must have ________ of Pb, or Pb equivalent.
Definition
1/32"
Term
Fluoroscopic protection features should include a bucky slot cover, and protective lead curtains that attach to the image intensifier. Both of these items should be _______ Pb, or Pb equivalent.
Definition
.25
Term
where is the fetal dosmieter worn ?
Definition
waist level
Term
The safest place to stand during an exam is at a __ degree angle to the patient
Definition
90
Term
Annual Effective Dose Limit for diagnostic Imaging Personnel in REM and mSV?
Definition
5 REM
50 mSV
Term
General public radiation dose in REM and mSV?
Definition
.5 REM
5 mSV
Term
What is the #1 source of scatter
Definition
The Patient
Term
What kind of dosimeter has a non-destructive readout?
Definition
OSL (optically stimulated luminescence)
Term
Where does secondary radiation come from?
Definition
scatter and leakage
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