Term
| This bacterium is mostly responsible for peptic ulcer disease? |
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Definition
|
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Term
| T/F. GERD (chronic) can lead to Barretts Esophagus/ Esophageal adenocarcinoma? |
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Definition
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|
Term
| T/F. Decrease in pepsin causes PUD? |
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Definition
| False, increase in pepsin. |
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Term
| T/F. Death can occur as a result of PUD? |
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Definition
|
|
Term
| PUD function to _____ the pH of the stomach? |
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Definition
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Term
| ____ is a drug used to treat both PUD and GERD? |
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Definition
|
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Term
|
Definition
| Competitive H2 receptor antagonist |
|
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Term
| Pepcid (famotidine) Pharm effect? |
|
Definition
| Inhibits histamine stimulated gastric acid secretion. |
|
|
Term
| Typically both PUD and GERD meds have what Key drug interaction? |
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Definition
| Reduce absorption of "conazole"s |
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Term
| Specifically, Pepcid (famotidine) inhibits absorption of _____ inhibitors? |
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Definition
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|
Term
| H2 receptor antagonists share what suffix? |
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Definition
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|
Term
| Proton pump inhibots bind what _____? |
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Definition
|
|
Term
| Prilosec (omeprazole) MOA? |
|
Definition
| non competitive inhibitor of K-ATPase |
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|
Term
| Prilosec (omeprazole) pharm effect ? |
|
Definition
| Inhibits gastric acid secretion |
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|
Term
| Superior to H2 antagonists, ____ is used to treat PUD and GERD? |
|
Definition
|
|
Term
| Prilosec (omeprazole) key drug interaction? |
|
Definition
| inhibits conversion of plavix prodrug to its active form. |
|
|
Term
| What is the suffix for proton pump inhibitors? |
|
Definition
|
|
Term
| Alginic acid is used to treat? |
|
Definition
|
|
Term
| Carafate (sucralfate) MOA? |
|
Definition
| Binds ulcer site as a gastroprotective suspension |
|
|
Term
| These _____ are used to fight H. pylori and are combined with protein pump inhibitors? |
|
Definition
Antibiotics
Clarithromycin
Amoxicillin |
|
|
Term
| Four primary compounds of Antacids? |
|
Definition
Sodium bicarbonate
Magnesium salts
Aluminum salts
Calcium carbonate |
|
|
Term
|
Definition
Alginic Acid
Acid precipitates with sodium bicarb to form sodium alginate, floating on the surface it creates a barrier between the stomach and the esophagus |
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|
Term
| Reglan (metoclopramide) is contraindicated with what medications? |
|
Definition
|
|
Term
| Reglan (metoclopramide) MOA? |
|
Definition
| Dopamine receptor antagonist. |
|
|
Term
| What neurotransmitters mediate emesis? |
|
Definition
Histamine
Dopamine
Serotonin
Acetylcholine |
|
|
Term
| _____ and ______ because of their MOA have parkinson sides effects at high doses when treating N/V? |
|
Definition
Compazine (prochlorperazine)
Reglan (metoclopramide) |
|
|
Term
| Compazine and reglan inhibit the chemoreceptor trigger zone by what MOA? |
|
Definition
| Dopamine Receptor Antagonist |
|
|
Term
| Phernergan (promethazine) is a _____ used to treat N/V? |
|
Definition
|
|
Term
| Antivert (meclinzine) is an ____ used to treat N/V? |
|
Definition
|
|
Term
| Zofram (ondansetron) is an ______ that blocks central and peripheral vominting reflexes? |
|
Definition
| Serontonin, 5-HT3 antagonist |
|
|
Term
| Key interaction (drug) with Zofran (ondansetron) ____ (2) |
|
Definition
|
|
Term
| T/F. Anti-emetics are all receptor antagonists? |
|
Definition
| False, Cannabinoids, agonize CB1 receptor |
|
|
Term
| ___ salts can cause constipation, while ___ salts cause diarrhea? |
|
Definition
|
|
Term
| Milk of magnesia, Mg(OH2) MOA? |
|
Definition
| Osmotically increase water content of feces |
|
|
Term
|
Definition
| Absorbs water and expands |
|
|
Term
|
Definition
|
|
Term
| Colace (docusate) pharm effects? |
|
Definition
| Allows intestinal fluids to penetrate fecal mass |
|
|
Term
|
Definition
| Increase mucosal permeability, resulting in movement of fluid across the intestinal lumen. |
|
|
Term
| Linzess (linaclotide) Pharm effect? |
|
Definition
| Stimulates bowel muscle contractions |
|
|
Term
| Linzess (linaclotide) MOA? |
|
Definition
| Stimulates intestinal guanylate cyclase |
|
|
Term
| Amitiza (lubiprostone) MOA? |
|
Definition
| Activates CIC-2 chloride channels |
|
|
Term
| Amitiza (lubiprostone) pharm effect? |
|
Definition
| Increases intestinal fluid secretion and motility. |
|
|
Term
| ___ is a contraindication for GI motility drugs? |
|
Definition
|
|
Term
| Amitiza (lubiprostone) key drug interaction? |
|
Definition
| Zydelig ( idelalisib) - fatal diarrhea |
|
|
Term
| Kaopectate (kaolin and pectin) treats _____, by what mechanism? |
|
Definition
Diarrhea
Binding large numbers bacterial and toxins to reduce water loss. |
|
|
Term
| Lomotil (diphenooxylate) acts similar to an _____ causing constipation. |
|
Definition
|
|
Term
| Can you overdose on Lomotil (diphenooxylate)? |
|
Definition
| Yes, similar effects as opiods |
|
|
Term
| Imodium (loperamide) MOA? |
|
Definition
Alters motor function
Delays passage of fluid |
|
|
Term
| Imodium (loperamide) is used to treat ___? |
|
Definition
|
|
Term
| Bentyl (dicyclomine) is an ____, that acts _______, reducing ___? |
|
Definition
Antispasmodic
Antagonist muscarinic receptors
Relaxes muscle and reduces hypermotility. |
|
|
Term
| These supplements should be avoided when taking Bentyl (dicyclomine)? |
|
Definition
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