Term
|
Definition
Penetrates CNS
Pseudomonas, ETEC. G- rod UTIs
Gonorrhea (now use Ceftriaxone)
Anthrax
Pulmonary G- aerobes
Also legionella (alt to azithromycin)
Mycoplasma pneumo |
|
|
Term
|
Definition
Pulmonary G- aerobes
Comm acq pneumo, strep pneumo w/ penicillin resistance |
|
|
Term
|
Definition
DHPS, DHFR inhibitor combo.
Use: Recurrent UTI, exacerbation of chronic bronchitis.
Quite wide spectrum.
Adverse: megaloblastic anemia, leukopenia. Use leucovorin.
Resistance to TMP: reduced permeability, overexpress DHFR, mutate DHFR |
|
|
Term
|
Definition
DHPS inhibitor, reversible
Uses: UTIs (with TMP)
Pharm: Oral
Adverse: preggos, infants, bilirubin displacement. G6PD deficiency causes allergy and hemolytic anemia. |
|
|
Term
| Why are quinolones well tolerated? |
|
Definition
Bacteria actively growing
Affinity difference |
|
|
Term
|
Definition
2- relaxes supercoiling
4- decatenation |
|
|
Term
|
Definition
Efflux
Target mutation
Bacteria CANNOT chemically alter the drug |
|
|
Term
|
Definition
Metal ions chelate, antacids
Alter theophylline met
QTc interval prolongation |
|
|
Term
|
Definition
not in children, preggos. cartilage damage
Tendon damage.rupture, phototox |
|
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