Term
| Characteristics of metastatic tumors |
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Definition
well-cirumscribed lesions at the gray-white junction
Lung and breast are common sources (kidney is a 3rd) |
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Term
| Most common primary tumors in adults |
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Definition
glioblastoma multiforme
meningioma
schwannoma |
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Term
| most common location for primary tumors in children |
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Definition
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Term
| Most common tumors in children |
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Definition
| pilocytic astrocytoma, ependymoma and medulloblastoma |
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Term
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Definition
malignant, high grade tumor of astrocytes
most common malignant cns tumor in adults
characteristically crosses CC "butterfly lesion"
characterized by regions of necrosis surrounded by tumor cells |
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Term
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Definition
Benign tumor of arachnoid cells
most common benign CNS tumor in adults
more commonly seen in women
May present w/seizures (tumor does not invade cortex)
HIsto shows whorled pattern w/ psammoma bodies |
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Term
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Definition
most freq involves CN VIII
tumor cells are S-100 positive
bilateral tumors often assoc w/ NF-2
benign tumor of arachnoid cells |
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Term
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Definition
Malignant tumor of oligodendrocytes
calcified tumor in white matter -usually frontal lobe
may present w/seizures
well-circumscribed
Fried-egg appearance of cells on biopsy |
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Term
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Definition
Benign tumor of astrocytes
Most common CNS tumor in children - usually cerebellum
Biopsy shows rosenthal fibers and eosinophilc granular bodies |
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Term
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Definition
malignant tumor of cells of cerebellum
usually in children
Histo - small, round blue cells; Homer-Write rosettes
poor prognosis, may metastasize to cauda equina |
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Term
|
Definition
malignant tumor, usually seen in children
most comonly in 4th ventricle
characteristically will see pseudorosettes on biopsy |
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Term
|
Definition
Tumor arises from remnants of Rathke's pouch
Presents in children/young adults
May crompress optic chiasm leading to bitemporal hemianopsia
calcifications are commonly seen 'tooth-like' tissue
benign but tends to recur after resection |
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Term
| Spongiform encephalopathy |
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Definition
Prion derived - Beta-pleated confromation
Diseased form prion converts normal protein -domino effect
Creutzfedlt-Jakob most common spongiform encephalopathy
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Term
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Definition
Deg disease of frontal and temporal cortex (spares parietal/occ)
characterized by round aggregates of tau (pick bodies) in neurons
behavioral and language symptoms arise early
progresses to dementia |
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Term
| PML (progressive multifocal leukoencephalopathy) |
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Definition
JC virus infection of oligodendrocytes (white matter)
Seen in immunosuppressed - AIDS or leukemia often
presents w/ visual loss, weakness demential, rapidly progressing until death |
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Term
Subacute sclerosing panencephalitis
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Definition
Progressive debilitating encephalitis leading to death
Caused by Measles virus |
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Term
| Central pontine myelinolysis |
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Definition
focal demyelination of the pons
due to rapid intravenous correction of hyponaturemia
occurs in severely malnourished - alcoholics, anorexia |
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