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Pulmonary Failure
Smythe
13
Pharmacology
Pre-School
01/06/2010

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Cards

Term
Alveolar Dead Space
Definition
Ventilation w/o perfusion. If this exceeds 0.6 as a fraction of total ventilation mechanical ventilation may be required.
Term
Pulmonary Shunt
Definition
Area of lung where gas exchange cannot occur, if this exceeds 5% by much then this may become clinically significant
Term
minimal acceptable PaO2
Definition
60mm Hg or 90% saturated
Term
Total dead space
Definition
anatomic dead space (150ml) + alveolar dead space
Term
ALI definition
Definition
acute hypoxemia with PaO2:FiO2 < 300mm Hg
Term
ARDS definiton
Definition
acute hypoxemia w/PaO2 < 200mm Hg
Term
SIRS
Definition
systemic inflammatory response syndrome, ARDS is a component
Term
lung capacity in ARDS
Definition
20% - 30% of total lung capacity. complicating factor that some lung is not uniformly injured, some portion is compliant
Term
compliance
Definition
volume/pressure. less compliant lungs have high airway pressures reducing compliance
Term
tidal volume strategy with mechanical ventilation in ARDS
Definition
low tidal volume of 6ml/kg
Term
midazolam
Definition
rapid onset, short acting (in healthy patients, longer in ICU). Vd increases with renal impairment. also cyp 3A4 metabolism, inhibitors increase duration
Term
diazepam
Definition
long half-life, active metabolites, cheapest of the 'pams'
Term
propofol
Definition
aseptic techniques necessary; most expensive; rapid onset, short duration; pancreatitis, high calorie; decreases intracranial pressure;
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