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Pulm- Signs and Symptoms
Lect 3 On
62
Medical
Graduate
10/22/2012

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Term
Interstitial Lung Disease
Definition
a. affecting interstitium, lung tissue, and space around air sacs
Term
Idiopathic Pulmonary Fibrosis (UIP)
Definition
1. Diagnosis of Exclusion
2. Usually age >50
3. Insidious unexplained Dyspnea upon exertion or at rest (most common)
4. Bibasilar inspiratory crackles
5. Dry cough
6. Decreased activity tolerance
7. Cyanosis/Clubbing nails
8. Tachypnea
9. Signs of Right Ventricle Failure
Term
Sarcoidosis
Definition
1. More common African American, female, age 20-40
2. Often no symptoms, but abnormal CXR
3. Can have fever, SOB, neurologic or vision abnormalities, enlarged Lymph nodes, Hepatomegaly or Splenomegaly, dry cough, weight loss, kidney stones
Term
Bronchiolitis Obliterans
Definition
See Cryptogenic organizing pneumonia COP
Term
Non-cryptogenic Organizing Pneumonia
Definition
1. Associated with HIV, Rheumatic Pneumonia, Drug induced, Radiation, Cocaine, Collagen Vascular Disease, Lung or Bone Marrow Transplant, Heme disorders/malignancies, and coronary artery bypass graft
Term
Silicosis
Definition
1. Simple Chronic: Rxn to free crystalline silica long term (20yrs)
2. Accelerated: larger amount over 5-15 yrs
3. Acute: large amount over short term
4. Inflamed lungs, can fill w/ fluid
5. Chronic cough
6. SOB, can be severe and worse w/ exercise
7. More common with Acute: fever, weight loss
Term
Coal Worker's Pneumoconiosis
Definition
1. Significant amount of exposure to coal, graphite, or man made carbon
2. Lung inflammation and scarring
3. Simple: 1-2 mm noudules
4. Complicated: >1cm masses of fibrotic areas w/ cavaties
5. Age > 50
6. SOB, chronic cough, crackles
Term
Asbestosis
Definition
1. long-term heavy inhalation
2. Inc. risk in smokers
3. SOB, cough, chest tighness/pain
4. Clubbing, lung crackles
5. Related Dz: pleural plaques, malignant mesothelioma
Term
Hypersensitivity Pneumonitis
Definition
Acute:
1. Cough, fever, chills
2. SOB, malaise
Subacute:
1. Wheeze w/ SOB
Chronic:
1. dry cough w/ SOB
2. Weight loss, loss of appetite
Term
Drug Inuduced Parenchymal Disease
Definition
1. Usually Hypersensitivity Pneumonitis, Eosinophilic LD, or organizing pneumonia
2. Any drug but commonly: Bleomycin
Term
Radiation Induced Lung Disease
Definition
1. hypoventilation
Term
Obesity- Restrictive Lung Disease
Definition
1. Hypoventilation Syndrome- BMI >30, Hypercapnea
2. Decreased lung volume
Term
Diaphragm Paralysis Restrictive Lung Disease
Definition
1. hypoventilation
Term
Chest Wall Disease RLD
Definition
1. Hypoventilation
Term
Tuberculosis
Definition
1. Previous contact w/ TB
2. Immunocompromised, more likely
3. Cough, fever, sweats
4. Weight loss
5. Hemoptysis- only seen late if seen
Term
Asthma
Definition
1. cough, wheezing, pulsus paradoxus
2. SOB, chest tighness
3. sputum production
4. decreased exercise tolerance
5. May be associated w/ allergens, occupation, medications, or exercise
6. Family Hx important
Term
COPD
Definition
1. Men >women, older, lower SEC status,
2. Airway obstruction, inflammation, structural chxs
3.Dyspnea
4. chronic cough and sputum
5. Hx exposure to smoke, environmental pollution, etc.
Term
Chronic Bronchitis
Definition
1. increased mucus production
2. recurrent cough, intermittent dyspnea
3. frequent infections
4. Pedal edema
5. hemoptysis
6. cyanosis, wheezing, diminished breath sounds,
7. weight gain
8. distant heart sounds
Term
Emphysema
Definition
1. chronic cigarette smoking
2. slowly progressive dyspnea
3. minimal cough, scant sputum, minimal wheezing
3. occasional infections,
4. significant wt loss
5. barrel chest, pursed lips, accessory muscles
6. decreased breath sounds
Term
Bronchiectasis
Definition
1. chronic cough
2. blood streaked sputum
3. clubbing
4. recurrent pneumonia
Term
Cystic Fibrosis
Definition
1. Airway filled w/ mucus = bacterial infections, widened airway
2. Cor pulmonale, pneumothorax, nasal polyps, chronic sinusitis
3. Exocrine pancreatic- malnutrition, diabetes mellitis, steatorrhea
4. Cirrhosis- portal hypertension
5. kidney and gallstones
6. salty sweat
Term
Venous Thromboembolism
Definition
1. pain tenderness, warmth, edema, erythema
2. dilated collateral vessels
Term
Acute Pulmonary Embolus
Definition
1. Leg pain, swelling, erythema, warmth
2. dyspnea, chest pain, hemoptysis, all sudden
3. tachypnea, fever, tachycardia
Term
Primary Pulmonary Hypertension
Definition
1. progressive dyspnea, cough, chest pain
2. syncope, hemoptysis, pedal edema
3. diminished expansion, crackles
4. JVD, hepatomegaly
Term
Secondary Pulmonary Hypertension
Definition
1. Cardiac disease- pressure or volume overload
2. Respiratory disease- vasoconstriction
Term
Pleural Effusion
Definition
1. chest pain, cough, tachypnea, SOB, dyspnea
2. fever
3. dullness
Term
Pleurisy
Definition
1. pain that worsens with movement or deep breaths
Term
Pneumothoraces
Definition
1. sharp chest pain made worse by cough or deep breath
2.SOB
3. Can have tachycardia, fatigue, nasal flaring
4. decreased or no breath sounds over affected area
Term
Nosocomial Pneumonia
Definition
1. HAP developing after 48-72 hrs
2. fever, cough, worsening oxygenation
Term
Hospital Acquired Pneumonia
Definition
1. fever, chills, anorexia, nausea vomiting
2. SOB, sharp chest pain
3. confusion in the elderly
Term
Mesothelioma
Definition
1. LB pain, chest pain, SOB
2. persistent cough, fever, wt loss
3. Hx asbestos exposure
Term
Community Acquired Pneumonia
Definition
1. Fever, cough
2. tachycardia, crackles over lungs
3. tachypnea, chest pain, rales, consolidation
4. Confusion in the elderly
Term
Pneumonia in Immunocompromised Pt
Definition
1. HIV/AIDS, organ transplant recipient, chemotherapy, heme malignancies, long-term high dose steroids, splenectomy, sickle cell disease
Term
Pulmonary Abcess
Definition
1. cough, fever, chills
2. purulent sputum
3. chest pain, SOB, wheezing
4. consolidation, bronchial breath sounds
Term
Empyema
Definition
1. chest pain, dry cough, fever chills, SOB
2. excessive sweating
3. wt loss, malaise
4. decrease breath sounds or friction rub
Term
Lung Cancer Risk Factors
Definition
1. smoking
2. occupational- asbestos, radon, metals
3. COPD
Term
Lung Cancer Epidemiology
Definition
1. Higher death rate than some cx combined
2. cigarette leading cause
3. quitting smoking does dec. risk
Term
Bronchiogenic Carcinoma
Definition
1. small cell
2. non-small cell
Term
Carcinoid Tumors
Definition
1. Often no symptoms, very vague
2. chest pain, cough, hemoptysis, SOB, wheezing, tachycardia, recurrent pneumonia
Term
Metastatic Tumors
Definition
1. bone pain, especially back pain = poor prognosis
2. N/V, headaches
2. mental status change, seizures, incoordination
Term
Pulmonary Nodules
Definition
1. older, Hx smoking, previous hx cancer
2. Solitary- <3c
3. Spiculated- high chance malignancy
Usually an incidental finding
Term
Small Cell Lung Cancer
Definition
1. bloody sputum
2. cough, chest pain, anorexia, SOB, wheezing, weight loss, anorexia
3. hoarseness, atelectasis
4. Superior vena cava syndrome
Term
Nonsmall Cell Cancer
Definition
1. Squamous cell- 30%, male, centrally with mainstem or lobar bronchus
2. Adenocarcinoma- 35% women, some non-smokers, periphery of lung
3. Large cell 10%, poorly differentiated
4. Chest pain, cough, hemoptysis, fatigue, anorexia, wt loss, SOB, wheezing, hoarseness
5. may hear fluid around lung, atelectasis
Term
Paraneoplastic Syndrome
Definition
1. consequence of cancer
2. Cushing's syndrome, SIADH, hypercalcemia, Lambert-Eaton Myasthenic Syndrome, encephalitis, cerebellar degeneration, acanthosis nigrans
Term
Mediastinal Masses
Definition
1. chest pain, chills, fever, cough, hemoptysis
2. SOB, hoarseness, wt loss
3. stridor, lymphadadenopathy
Term
Idiopathic Pulm Fibrosis- Chronic Progressive
Definition
extensive deposition of Collagen leading to widespread fibrosis
Term
Idiopathic Pulm Fibrosis- Acute Exacerbation
Definition
1. Within 30 days
2. Previous Dx
3. Worsening or New Dyspnea, otherwise unexplained
4. New Bilateral ground glass abnormality or consolidation superimposed on reticular or honeycomb background.
5. No evidence of Pulm Infection
Term
Cryptogenic Organizing Pneumonia
Definition
1. Begins with flu-like Symps
2. Progressively mild dyspnea
3. Anorexia, weight loss
4. Focal, sparse crackles
Term
Acute Respiratory Failure
Definition
1. Hypoxia with (Type II) or without (type I) hypercapnea
2. Caused by pulmonary or cardiac dysfunction
3. V/Q mismatch
Term
Acute Respiratory Distress Syndrome
Definition
1. dyspnea, tachypnea, SOB
2. low BP, organ failure, cyanosis
3.Abnormal breath sounds
Term
Hyaline Membrane Disease
Definition
1. Infants (especially preterm) displaying respiratory distress
2. tachypnea, cyanosis, expiratory grunting
3. poor air movement on auscultation, despite increased respiratory effort
4. hypoexpansion and air bronchograms on CXR, doming of diaphragm
Term
Acute Asthma
Definition
"asthma attack"
1. SOB, wheezing, chest tightness
2. coughing, decreased breath sounds
3. accessory respiratory muscles, paradoxical pulse, cyanosis
Term
Chronic Asthma
Definition
1. inflammation of airway, reversible airflow obstruction, bronchospasm w/ episodes of acute asthma
Term
Lower Respiratory Tract Infection
Definition
1. bronchitis
2. pneumonia
Term
Obstructive Sleep Apnea
Definition
1. loud snoring, observation of apnea/gasping by bedmate
2. hypertension, large neck circumference
3. Daytime sleepiness may or may not be present
4. obesity, retrognathia, large tongue
Term
Central Sleep Apnea
Definition
1. fatigue, sleepiness, headaches
2. dysphagia, voice change, weakness or numbness throughout body
Term
Apneustic Respiration
Definition
1. decerebrate posturing, fixed dilated pupils
2. coma or profound stupor, quadriparesis
3. absent corneal reflex
4. No gag reflex
5. pattern of breathing characterized by a prolonged inspiratory phase followed by expiration apnea
6. Associated w/ head injury
Term
Ataxic Respiration
Definition
1. complete irregularity of breathing, irregular pauses, increasing periods of apnea
2. More irregular than Biot's breathing
Term
Cheyne-Stokes Respiration
Definition
1. abnormal pattern of breathing progressively deeper, sometimes faster, followed by gradual decrease that results in apnea
Term
Kaposi Sarcoma
Definition
1. most common malignancy in pts w/ HIV
2. Skin most common, involve airway, lung tissue, mediastinal lymph nodes and pleura
3. cough, dyspnea, fever
Term
HIV associated
Definition
1. Cytomegalovirus- dyspnea, non-productive cough, fever, diffuse opacities on CXR ("Owl's eye")
2. Atypical mycobacteria MAC- persistent fever, diarrhea, WASTING, disseminated pulmonary involvement
3. Fungal pneumonia- meningitis, diffuse infiltrates most common on CXR
4. Pulmonary Aspergilosis- cavitation and hemoptysis, invasive parenchymal infection, dyspnea and airway obstruction
5. Pulmonary HTN
6. ILD
7. Immune reconstitution syndrome- deterioration due to recovery of immune system, AIDS pt on HAART, appears like infection or inflammatory
Term
PCP (jiroveci) pneumonia
Definition
1. fungal- gradual onset
2. fever, cough (generally non-productive), progressive dyspnea
3. Other: fatigue, chills, chest pain, wt loss
4. HIV associated
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