Tolerance

Cessation shows distinct withdrawl

Larger Ammounts

Tried to cut down

More Time Spent

Neglect activities

Use depite Problems

CNS:Increase Focus, Vigilence, Attention, Euphoria

Muscle: Relaxation

CV: increased HR/SV

GI: motility, acid

Clotting: Plate Aggregation, Endothelial Damage

Weight Loss

Cigars: Neutral form-> absorbed in Mouth

Cigarettes: Conjugate Acid-> Mucociliary Trees deprotonates to neutral-> absorption within lungs

What are the main drugs used to aide in smoking cessation?

What is the mechanism of each?

What is the effect of each?

Bupropion- DA, 5HT, Norepi Ruptake block(atypical anti)

Effect: Decreases depression

Gamma-Vinyl Chloride- Inhibits GABA degradation

Effect: Decreases Craving/Seeking behavior

Bromocriptine- Dopamine Agonist

Effect: decrease Reward

Verenicline- Nicotine Partial Ag

Effect: Decrease Craving and Withdrawal