Term
|
Definition
| the study of the effects of drugs on the nervous system and behavior |
|
|
Term
|
Definition
| the changes a drug produces in an animals physiological processes and behavior |
|
|
Term
|
Definition
| a location at which molecules located on or in cells of the body thus affecting some biochemical processes of these cells |
|
|
Term
|
Definition
| the process by which drugs are absorbed , distributed within the body metabolized and excreted. |
|
|
Term
|
Definition
| injection of a substance directly into the vein |
|
|
Term
| intraparetineal injection |
|
Definition
| injection of a substance into the paretineal cavity the space that surrounds the stomach intestines liver and other abdominal oragans |
|
|
Term
|
Definition
| injection of substance into a muscle |
|
|
Term
|
Definition
| injection of substance into the space beneath the skin |
|
|
Term
|
Definition
| administration of a substance by placing it beneath the tongue |
|
|
Term
| sublingual administration |
|
Definition
| administration of a substance by placing it beneath the tongue |
|
|
Term
| intrarectal administration |
|
Definition
| administration of a substance into the rectum |
|
|
Term
|
Definition
| administration of a vaporous substance into the lungs |
|
|
Term
|
Definition
| administration of a substance directly onto the skin or mucous membrane |
|
|
Term
| intracerebral administration |
|
Definition
| administration of a substance directly into the brain |
|
|
Term
| intracerebroventricular administration |
|
Definition
| administration of a substance into one of the cerebral ventricles |
|
|
Term
|
Definition
| a graph of the magnitude of an effect of a drug as a function of the amount of a drug administered |
|
|
Term
|
Definition
| the ratio between the dose that produces the desired effect in 50 percent of the animals and the dose that produces toxic effects in 50 percent of the animals |
|
|
Term
|
Definition
| the readiness with which two molecules join together |
|
|
Term
|
Definition
| a decrease in the effectiveness of a drug that is administered repeatedly |
|
|
Term
|
Definition
| an increase in the effectiveness of a drug that is administered repeatedly |
|
|
Term
|
Definition
| the appearance of symptoms opposite to those produced by a drug when the drug is administered repeatedly and then suddenly no longer taken. |
|
|
Term
|
Definition
| an inert substance that is given to an organism in lieu of physiologically active drug used experimentally to control for the effects of mere administration of a drug |
|
|
Term
|
Definition
| a drug that opposes or inhibits the effects of a particular neurotransmitter on the post-synaptic cell |
|
|
Term
|
Definition
| a drug that facilitates the effects of a particular neurotransmitter on the post synaptic cell |
|
|
Term
|
Definition
| a drug that binds with and activates a receptor |
|
|
Term
|
Definition
| a drug that binds with a receptor but does not activate it prevents the natural ligand from binding to the recptor |
|
|
Term
|
Definition
| a synonym for receptor blocker |
|
|
Term
|
Definition
| binding of a drug to a site on a receptor does not interfere with the binding site for the principal ligand |
|
|
Term
|
Definition
| a drug that attaches to a binding site on a receptor and interfere with the action of the receptor does not interfere with the site for the principal ligand |
|
|
Term
|
Definition
| a drug that attaches to a binding site on a receptor and facilitates the action of the receptor does not interfere with the binding site for the principal ligand |
|
|
Term
|
Definition
| a cofactor that supplies acetate for the synthesis of acetylcholine |
|
|
Term
| choline acetyltransferase |
|
Definition
| the enzyme that transfers the acetate ion from acetyl coenzyme A to choline producing the neurotransmitter acetylcholine |
|
|
Term
|
Definition
| an acetylcholine antagonist prevents release of by terminal buttons |
|
|
Term
|
Definition
| a poison produces by a spider that triggers the release of acetylcholine |
|
|
Term
|
Definition
| a drug that inhibits the activity of acetylcholinesterase |
|
|
Term
|
Definition
| an ionotropic acetlycholine receptor that is stimulated by nicotine and blocked by curare |
|
|
Term
|
Definition
| a metabotropic acetylcholine receptor that is stimulated by muscarine and blocked by atopine |
|
|
Term
|
Definition
| a drug that blocks muscarinic acetlycholinereceptors |
|
|
Term
|
Definition
| adrug that blocks nicotinic actylcholine receptors |
|
|
Term
|
Definition
| a class of amines that incluudes indolamines such as serotonin and catecholamines such as dopamine nor-epinephrine and epinephrine |
|
|
Term
|
Definition
| a class of amines that includes the neurotransmitters doapmine norepinephrine and epinephrine |
|
|
Term
|
Definition
| a neurotransmitter one of the catecholamines |
|
|
Term
|
Definition
| the levoratatory form of DOPA the precursor of the catecholomines often used to treat Parkinson disease because of its effect as a dopamine agonist |
|
|
Term
|
Definition
| a system of neurons originating in the substancia nigra and terminating in the neostriatum |
|
|
Term
|
Definition
| a system of dopaminergic neurons originating in the ventral tegmental area and terminating in the nucleus accumbens amygdala and hippocampus |
|
|
Term
|
Definition
| a system of dopaminergic neurons originating in the ventral tegmental area and terminating in the pre frontal cortex |
|
|
Term
|
Definition
| a drug that blocks the activity of tyrosine hydoxylase and thus interferes with the synthesis of the catecholamines |
|
|
Term
|
Definition
| a drug that interferes with the storage of monomines in synaptic vesicles |
|
|
Term
|
Definition
| a drug that inhibits the reuptake of dopamine |
|
|
Term
|
Definition
| a class of enzymes that destroy the monoamines dopamine norepinephrine and serotonin |
|
|
Term
|
Definition
| a drug that blocks the activity of MAO_B acts as a dopamine antagonist |
|
|
Term
|
Definition
| a drug that reduces the symptoms of schizophrenia by blocking dopamine D2 receptors |
|
|
Term
|
Definition
| one of the catecholamines s neurotransmitter found in the brain and in the sympathetic division of the autonomic nervous system |
|
|
Term
|
Definition
| one of the catecholomines a hromone secreted by the adrenal medulla serves also as a neurotransmitter in the brain |
|
|
Term
|
Definition
| a drug that inhibits the activity of the enzyme dopamine B hydroxylase and thus blocks the production of norepinephrine |
|
|
Term
|
Definition
| a dark colored group of noradrenergic cell bodies located in the pons near the rostral end of the floor of the fourth ventricle |
|
|
Term
|
Definition
| a drug that blocks presynaptic noradrenergic receptors and hence acts as an agonist stimulating the synthesis and release of NE |
|
|
Term
|
Definition
| an indolamine neurotransmitter also called 5 hydroxytryptamine |
|
|
Term
|
Definition
| a drug that inhibits the activity of tryptophan hydroxylase and thus interferes with the synthesis of serotonin |
|
|
Term
|
Definition
| a drug that stimulates serotonin receptors |
|
|
Term
|
Definition
| a drug that serves as a noradrenergic and serotonergic agonist also known as excasty has excitatory and hallucinogenic effects |
|
|
Term
|
Definition
| a neurotransmitter that plays an important role in stimulating wakefulness |
|
|
Term
|
Definition
| an amino acid the most important excitatory neurotransmitter in the brain |
|
|
Term
|
Definition
| a specialized ionotropic glutamate receptor that controls a sodium channel that is normally blocked by mg 2 ions has several other binding sites |
|
|
Term
|
Definition
| an ionotropic glutamate receptor that controls a sodium channel stimulated by kainic acid |
|
|
Term
|
Definition
| an ionotropic glutamate receptor that controls a sodium channel stimulated by kainic acid |
|
|
Term
|
Definition
| phencyclidine a drug that binds with the PCP binding site of the NMDA receptor and serves ad an indirect antagonist |
|
|
Term
|
Definition
| an amino acid the most important inhibitory neurotransmitter in the brain |
|
|
Term
|
Definition
| a drug that inhibits the activity of GAD and thus blocks the synthesis of GABA |
|
|
Term
|
Definition
| a direct agonist for the GABA binding site on the GABA A receptor |
|
|
Term
|
Definition
| a direct antagonist for the GABA binding site on the GABA A receptor |
|
|
Term
|
Definition
| a category of anxiolytic drugs an indirect agonist for the GABA A receptor |
|
|
Term
|
Definition
| an anxiety reducing effect |
|
|
Term
|
Definition
| an amino acid an important inhibitory neurotransmitter in the lower brain stem and spinal cord |
|
|
Term
|
Definition
| a direct antagonist for the glycine receptor |
|
|
Term
|
Definition
| a class of peptides secreted by the brain that cat as opiates |
|
|
Term
|
Definition
| one of the endogenous opiods |
|
|
Term
|
Definition
| a drug that blocks opiate receptors |
|
|
Term
|
Definition
| a lipid an endogenous ligand for receptors that bind with THC the active ingredient of marijuana |
|
|
Term
|
Definition
| the first cannabinoid to be discovered and probably the most important one |
|
|
Term
|
Definition
| a drug that blocks cannabinoid CB receptors |
|
|
Term
|
Definition
| a nucleoside a combination of ribose and adenine serves as a neuromodulator in the brain |
|
|
Term
|
Definition
| a drug that blocks adenosine receptors |
|
|
Term
|
Definition
| a gas produced by cells in the nervous system used as a means of communication between cells |
|
|
Term
|
Definition
| the enzyme responsible for the production of nitric oxide |
|
|
