Term
what is Eosinophilic Granuloma Complex (EGC) in cats?
its ______mediated
are they pruritic?
do they have primary or secondary lesions |
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Definition
-this is not a specific disease, but rather a rxn
pattern.
-OFTEN ALLERGY-MEDIATED (atopy, food, flea,
mosquito).
-Pruritus is variable!!
-Often have primary lesions |
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Term
| What are four syndromes cats with EGC get? |
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Definition
1. Eosinophilic plaques
2. Linear granuloma (eosinophilic granuloma)
3. Indolent ulcer (rodent ulcer, eosinophilic ulcer-
feline eosinophilic lip ulcer)
4. Mosquito bite Hypersensisitivity |
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Term
| what are six common features among all four syndromes of EGC? |
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Definition
1. MAY BE ALLERGY MEDIATED (atopy, food, flea,
mosquito)->work up for allergies
2. EOSINOPHILS OFTEN PREDOMINATE
3. May see all 4 lesions in an individual
4. DDX: bacterial/fungal infection or neoplasia
5. Dx: one of exclusion (may need to biopsy to rule
out above DDX)
6. Tx: avoidance of relevant allergens when
possible; hyposensitization therapy for atopy-
induced lesions; most respond to anti-
inflammatory doses of prednisone; occasionally
respond to Ab |
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Term
| what is the Tx for any of the four syndromes of EGC? |
|
Definition
1. avoidance of relevant allergens when
possible
2. hyposensitization therapy for atopy-induced
lesions
3. most respond to anti-inflammatory doses of
prednisone
4. occasionally respond to Antibiotics |
|
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Term
| what is the DDX for all four syndromes of EGC? |
|
Definition
| bacterial infection, fungal infection, neoplasia |
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Term
| what cell predominated in EGC reaction? |
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Definition
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Term
| what is Eosinophilic Plaque in EGC most often caused by? |
|
Definition
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Term
| what is the distribution of eosinophilic plaques in EGC? are they pruritic? are they dry or moist plaques? are other infections usually present? |
|
Definition
-often inguinal and ventral abdomen
-very pruritic
-Moist plaques
-2ndary infection often involved |
|
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Term
| what is Tx for Eosinophilic Plaques in EGC? |
|
Definition
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Term
| what is the etiology for Linear granuloma (eosinophilic granuloma) in EGC? |
|
Definition
-not usually associated with allergy
-may be genetic predisposition
-(cats<1 y/o spontaneously regress) |
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Term
describe the distribution of lesions in linear granuloma of EGC. shape? pruritic? location on body?
distribution |
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Definition
-linear, usually NON-pruritic
-caudal thighs, face, oral cavity of young cats
-may cause lower lip and chin swelling |
|
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Term
| what is the tx for linear granuloma of EGC is non-pruritic? what if it is pruritic? |
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Definition
-if not Pruritic then "scientific neglect"
-if pruritic, short-term systemic steroids |
|
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Term
| What are causes of Indolent ulcer in EGC? |
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Definition
| some cases are allergy mediated |
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Term
where are the lesions in Indolent Ulcer of EGC?
are they pruritic? what so the lesions look like? |
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Definition
-lesions are on upper lips and in oral cavity
-usually non pruritic and non-painful
-lesions are well-circumscribed, red-brown,
alopecic ulcers |
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Term
| what do painful oral Indolent Ulcer of EGC lead to? |
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Definition
| dysphagia and/or anorexia |
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Term
| what is tx for indolent ulcers of EGC? |
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Definition
-identify/trest specific allergy
-steroids if cannot accomplish this
-some may become refractory to steroids
-surgical removal if painful oral lesions are
refractory to medical treatment |
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Term
| what causes mosquito bite hypersensitivity in EGC? |
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Definition
| probably a Type I and/or Type IV hypersensitivity rxn |
|
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Term
| what kind of lesions are present in mosquito bite hypersensitivity EGC and what is their distribution? |
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Definition
-eruptive moist lesions
-on face, ears, and margins of pads |
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Term
| how do you treat mosquito bite hypersensitivity in EGC? |
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Definition
1. avoidance (house indoors, mosquito netting,
repellants)
2. steroids until resolution |
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