Term
Salicylic Acid
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms
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Definition
Prodrug: Aspirin
Linker group: Ester
Enzyme Activator: Esterase
Barrier: GI
Molecular Target: Analgesic
Disease/Symptoms Pain/Inflammation |
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Term
Prilosec/Nexium
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Pivampicillin
Linker group: Ester
Enzyme Activator: Esterase
Barrier: Absorption
Molecular Target: Transpeptidase
Disease/Symptoms: Acid Reflux |
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Term
Morphine
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Codeine
Linker group: Ether
Enzyme Activator: Cyt P450
Barrier: BBB
Molecular Target: Opioid Receptors
Disease/Symptoms: Pain |
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Term
Dopamine
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms? |
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Definition
Prodrug: Docarpamine
Linker group: Ester/Amide
Enzyme Activator: Esterase/Amidase
Barrier: BBB
Molecular Target: Basal ganglia
Disease/Symptoms: Parkinsons |
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Term
GABA
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Progabide
Linker group: Imine/Amide
Enzyme Activator: Esterase/Amidase
Barrier: BBB
Molecular Target: GABA Receptors
Disease/Symptoms: Epilepsy |
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Term
Etoposide
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Etopophos
Linker group: Phosphate ester
Enzyme Activator: Phosphatase
Barrier: Aq Solubility
Molecular Target: Topoisomerase II
Disease/Symptoms: Anti-cancer |
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Term
Prednisolone
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Prednisone phosphate
Linker group: Ester
Enzyme Activator: Phosphatase
Barrier: Aq Solubility
Molecular Target: Glucocorticoid receptors
Disease/Symptoms: Inflammation |
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Term
Epinephrine
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Dipivalyl Epinephrine
Linker group: Ester
Enzyme Activator: Esterase
Barrier: Absorption
Molecular Target: Adrenergic Receptors
Disease/Symptom: Glaucoma |
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Term
Mustard Agents
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Nitro-Mustards
Linker group: P-aromatic Nitro
Enzyme Activator: NADPH/P450 Reductase
Barrier: Non-specific toxicity
Molecular Target: DNA-Alkylation
Disease/Symptoms: Cancer |
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Term
Camptothecin
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: CPT4
Linker group: Quinone
Enzyme Activator: NQO1
Barrier: Non-specific toxicity
Molecular Target: DNA-Topoisomerase I
Disease/Symptom: Cancer |
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Term
Camptothecin
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Irinotecan
Linker group: Carbamate/Ester
Enzyme Activator: Esterase
Barrier: Non-specific toxicity
Molecular Target: DNA-Topoisomerase I
Disease/Symptoms: Cancer |
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Term
Valium
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: BDMA
Linker group: NN-Dimethyl Amine
Enzyme Activator: P450
Barrier: Solubility
Molecular Target: GABA Receptors
Disease/Symptoms: Sedative |
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Term
Dopamine
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Dopamine DHP
Linker group: Dihydropyridine
Enzyme Activator: NADH-Trans Hydrogenase
Barrier: BBB
Molecular Target: Basal Ganglia
Disease/Symptoms: Parkinsons |
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Term
Omeprazole Sulfenamide
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Omeprazole (Prilosec)
Linker group: Bioprecursor
Enzyme Activator: Stomach Acid
Barrier: Site selectivity
Molecular Target: H+/K+ ATPase Proton Pump
Disease/Symptoms: Acid Reflux |
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Term
Tazarotenic Acid
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Tazarotene
Linker group: Ethyl Ester
Enzyme Activator: Esterase
Barrier: Improved Topical Absorption
Molecular Target: Acne Bacteria
Disease/Symptoms: Acne |
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Term
Phenytoin
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Fosphentoin
Linker group: Phosphate
Enzyme Activator: Phosphatase
Barrier: Solubility
Molecular Target: Voltage gated Na Channels
Disease/Symptoms: Epilepsy |
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Term
Esomeprazole Sulfenamide
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Esomeprazole (Nexium)
Linker group: Bioprecursor
Enzyme Activator: Stomach acid
Barrier: Site Selectivity
Molecular Target: H+/K+ ATPase Proton Pump
Disease/Symptoms: Acid Reflux |
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Term
O-Desmethyl Tramadol
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Tramadol
Linker group: Methyl Ether
Enzyme Activator: CYP 2D6
Barrier: BBB
Molecular Target: Opioid Receptors
Disease/Symptom: Analgesic/Pain |
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Term
Dabigatran
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Dabigatran Etixilate
Linker group: Ethyl Ester
Enzyme Activator: Carboxy Esterase
Barrier: Inc Oral Bioavailability
Molecular Target: Direct Thrombin Inhibitor
Disease/Symptoms: Stroke/Anti-Coagulant |
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Term
Oseltamivir Carbocylate
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Oseltamivir (Tamiflu)
Linker group: Ethyl Ester
Enzyme Activator: Carboxy Esterase
Barrier: Oral Bioavailability
Molecular Target: Neuraminidase Inhibitor
Disease/Symptoms: Influenza |
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Term
Terbutaline
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Bambuterol
Linker group: Carbamate/Ester
Enzyme Activator: Butyrylcholinesterase
Barrier: Oral bioavailability
Molecular Target: B2-Agonist
Disease/Symptoms: Asthma and COPD/Bronchodilator |
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Term
AZT-Triphosphate
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms? |
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Definition
Prodrug: AZT
Linker group: Alcohol
Enzyme Activator: Host Thymidine Kinase
Barrier: Inc site specificity and lipophilicity
Molecular Target: HIV Reverse Transcriptase
Disease/Symptoms: HIV/AIDs |
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Term
Acyclovir
Prodrug?
Linker group?
Enzyme Activator?
Barrier?
Molecular Target?
Disease/Symptoms |
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Definition
Prodrug: Valacyclovir
Linker group: Ester
Enzyme Activator: Esterase
Barrier: Increased oral bioavailability
Molecular Target: Viral polymerase
Disease/Symptoms: Herpes Virus |
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Term
Nitrogen Mustard (PR104M)
Prodrug?
Linker Group?
Enzyme/Activator?
Barrier?
Molecular Target?
Disease/Symptoms? |
|
Definition
Prodrug: Nitrogen Mustard PR104
Linker Group: p-nitro group, and phosphate group
Enzyme/Activator: NADPH/P450 Reductase and phosphatase
Barrier: Decreased cytotoxicity and water solubility
Molecular Target: DNA alkylating agent
Disease/Symptoms: Cancer Chemotherapy |
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