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Princples of Bio
Test 2
120
Biology
Undergraduate 1
10/10/2010

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Term
Nucleotides
Definition
Monomers of nucleic acids, composed of sugar, phosphate, and nitrogenous base
Term
DNA
Definition
a nucleic acid that contains genetic instructions for the biological development of an organism, a nucleic acid made of nucleotide monomers
Term
Deoxyribose
Definition
sugar in DNA
Term
Pyrimidines
Definition
thymine, cytosine
Term
Purines
Definition
Adenine, guanine
Term
Ribose
Definition
sugar in RNA
Term
Hydrogen bonds between bases holds DNA together
Definition
Term
Replication
Definition
starts with separation of dna strands
produces 2 identical daughter molecules of dna
happens quickly, very few errors, dna has proofreading enzyme, dna has a repair enzyme
Term
Helicases
Definition
dna repair enzyme
Term
Genotype
Definition
organisms genetic makeup
Term
Phenotype
Definition
the characteristics we see, manifestation of genotype
Term
dna genotype is express through proteins, genes to proteins
Definition
Term
gene
Definition
a herditary unit of information, specify how to build proteins
Term
Transcription
Definition
in nucleus
Initation, enlongation, termination
produces genetic messages in the form of rna
Term
mRna
Definition
during transcription, it carries the genetic message out of the nucleus
Term
Translation
Definition
Genetic information written in codons is translated into amino acid sequences
ribosome attaches to mrna then trna translates message to a polypeptide
Term
Codon
Definition
set of 3 nucleotides that code for an amino acid
Term
Mutation
Definition
changes in dna base sequence caused by error in dna, or some type of mutagen
Term
Mutagen
Definition
anything that is capable of causing genetic change
Term
ways to alter a gene
Definition
substituting, inserting, or deleting nucleotides
Term
Virus
Definition
gene packed into protein, phages aka bacteriophage
Term
Lytic Cycle
Definition
When phage DNA enters a lytic cycle inside a bacterium, it is replicated, transcribed, and translated.
The new viral DNA and protein molecules then assemble into new phages, which burst from the host cell
Term
Lysogenic Cycle
Definition
phage DNA inserts into the host chromosome and is passed on to generations of daughter cells
Term
3 outcomes of lysogenic cycle
Definition
may continue to reproduce asymptomatically, may insert and alter function of host cell, may revert to the lytic cycle
Term
Prodromal Phase
Definition
knowing you are about to have an outbreak but it is not visible yet
Term
S and S
Definition
symptomatic and supportive, treat what appears clinically
Term
Universal Barriers
Definition
every patient treated has to be treated as if they were HIV positive
Term
Influenza
Definition
leading cause of human viral disesase, 2 main types (a,b)
Term
Antigenic drift
Definition
viruses are constantly changing
Term
3 steps to not get flu
Definition
get flu vaccine, take everyday precautions, take flu antiviral drugs
Term
anitviral drugs make disease milder but are not a substitute for vaccines
Definition
Term
Herpes virus
Definition
2nd leading cause of viral disease, has 8 types
Term
herpes 1 and 2
Definition
1. cold sores
2. genital
can affect hands and fingers known as herpes whitlow
Term
herpes 3
Definition
varicella zoster
causes chicken pox in children, causes shingles in adults, associated with nerves
Term
herpes 4
Definition
epstein barr
mono, associated with chronic fatigue symptom
Term
herpes 5
Definition
cytomagalo virus
most prominent congenital viral illness
Term
Congenital
Definition
passing from mom to baby
Term
herpes 6 and 7
Definition
human herpes virus 6 and 7
cause rash
Term
herpes 8
Definition
human herpes virus 8
Kaposi Sarcoma- seen in aids patients
Term
viruses are named based on 2 proteins found on the surface of the virus
Definition
h protein and n protein
Term
people to get h1n1 vaccine
Definition
pregnant women, caregivers for young children, all health care and emergency workers, anyone from 6months to 24 yrs old, older people already sick
Term
Ebola
Definition
hommorragic fever, makes you bleed out all orfaces, 50-90% mortality rate
Term
Morbidity
Definition
injures you, doesnt kill you
Term
3 ways viruses enter plants
Definition
contaminated farming tools, insects, trauma
Term
many viruses has rna as their genetic material
Definition
Term
envelope virus
Definition
steal host cell membrane as a protective envelope, can exit cell without bursting cell
Term
mumps
Definition
an envelope virus that swells up parotic gland
Term
corona virus
Definition
family of viruses that have a crown appearance, cause different diseases
Term
emerging virus
Definition
new or newly studied
RNA mutates faster than DNA
Changing host species
Globalization
Term
endemic
Definition
occurs regularly in a specific population or area
Term
epizootic
Definition
an epidemic in non humans
Term
epidemic
Definition
a disease that appears in a given population during a specific period at a rate that substantially unexpected
Term
Panzootic
Definition
affects animals of many different species
Term
pandemic©
Definition
an epidemic that spreads worldwide
Term
virulence
Definition
that ability of any microorganism to cause disease
Term
retrovirus
Definition
any virus that makes dna on an rna template, includes aids
Term
differentation
Definition
the process in which cells acquire a specialized structure and function, yields a variety of cell types
Term
somatic cells
Definition
all cells in the body besides sperm and egg
Term
dna packing
Definition
dna packed so tightly that some genes are prevented access to, helps regulate gene expression
tends to block gene expression by preventing access of transcription proteins to the DNA
Term
nuclear transplantation
Definition
most common cloning technique
nucleus is removed from egg cell then nucleus from an adult somatic cell is put in its place
Term
2 basic types of cloning
Definition
reproductive and therapeutic
Term
stem cells
Definition
cells that have not differentiated
Term
reproductive cloning used for
Definition
research, agriculture, and medicine
Term
embyronic stem cell
Definition
found in embryos, some embryonic fluid, more potential
Term
adult stem cells
Definition
found in bone marrow, less potential to differentiate, can become blood cells
Term
Asexual Reproduction
Definition
produced by a single parent, no sperm or egg, clone
Term
binary fission
Definition
how prokaryotic cells asexually reproduce, common in prokaryotes and protists
Term
dna molecule is only visible during cell division
Definition
Term
chromosomes replicate before cell starts dividing
Definition
Term
sister chromatids
Definition
chromosome copies, genetically identical
Term
centromere
Definition
where sister chromatids are joined at
Term
in the miotic phase
Definition
In mitosis, after the chromosomes coil up, a mitotic spindle moves them to the middle of the cell
The sister chromatids then separate and move to opposite poles of the cell, where two nuclei form
Term
cytokineses
Definition
in which the cell divides in 2, overlaps the end of mitosis
Term
prophase
Definition
first phase of mitosis, sister chromatids are formed
Term
centrosome
Definition
regulates the process of cell cycle
Term
miotic spindle
Definition
controlled by centrosome, an array of micotubules and proteins that form between opposite poles of the cell
Term
prometaphase
Definition
spindle extending across cell, nuclear envelope breaks down
Term
metaphase
Definition
chromosomes lined up at equator
Term
metaphase
Definition
chromosomes lined up at equator
Term
anaphase
Definition
sister chromatids split
Term
telophase
Definition
nucleus begins reforming
Term
cytokineses
Definition
movement of the cytoplasm
Term
cytokenesis differs in plant and animal cells
Definition
in animals- occurs by construction of the cell, results in complete cleavage
in plants- incomplete cleavage, cell plate splits the cell in 2
Term
3 functions of mitosis
Definition
growth, replacement of damaged of lost cells, asexual reproduction
Term
most cells divide only when stimulated
Definition
Term
anchorage dependance
Definition
most cells divide only when attached to a surface
Term
density dependent inhibition
Definition
when cells have formed a single layer then stop dividing, if some cells are removed they will divide to fill the gap until single layer is formed again
Term
growth factors
Definition
proteins secreted by cells that stimulate other cells to divide, excess growth factor can cause cancer
Term
apoptosis
Definition
programmed cell death, unfertilized egg cells
Term
phagocytosis
Definition
specialized type of endocytosis, dead cells engulfed and digested by adjacent cell (cell eating)
Term
malignant tumor
Definition
can invade other tissues, progressively get worse, metastasize
Term
metastasize
Definition
the tumor has moved to a location other than the original location
Term
benign tumor
Definition
do not grow in aggressive manner, do not invade other tissues, do not metastasize
Term
biopsy
Definition
taking a piece of tissue for examination
Term
excisional biopsy
Definition
take out entire tumor
Term
incisional biopsy
Definition
take a piece of tumor, leave most of it in place
Term
3 types of cancer therapy
Definition
radiation, chemo, surgery, or combination of all 3
Term
oncologist
Definition
doctor who treats cancer
Term
etiology
Definition
the study of what causes a disease
Term
2 major components to what causes diseases
Definition
genetics and environmental factors
Term
proto-oncogenes
Definition
normal gene that promotes cell division
Term
oncogene
Definition
caused my a mutation of a proto-oncogene,, causes cell to divide excessively
Term
tumor supressor genes
Definition
supress tumor growth when active
Term
Cancers result from a series of genetic changes in a cell lineage
Accumulations of mutations can lead to cancer
Families may be predisposed to some cancers
Definition
Term
predisposing condition
Definition
something that makes a disease of condition more likely to appear
Term
precipitating factor
Definition
something that may trigger the predisposing condition of manifest
Term
cancers are named according to the tissues they are found in
Definition
Term
carcinoma
Definition
cancer that originates in external of internal body covering
Term
sarcoma
Definition
cancer that occurs in tissues that support the body
Term
leukemias
Definition
cancers of blood related tissues
Term
lymphoma
Definition
cancers related to lymphicites
Term
locus
Definition
position on a chromosome that a gene occupies
Term
homologus chromosomes
Definition
pair of chromosomes, inherited from each parent that have corresponding gene sequences and pair up duing meiosis
Term
diploid
Definition
cells with 2 sets of chromosomes
Term
haploid
Definition
cells with 1 set of chromosomes (gametes, egg, sperm)
Term
meiosis
Definition
reduces the chromosome number from diploid to haploid, preceeded by chromsome duplication, cell divides twice to form 4 daughter cells
Term
meiosis 1
Definition
the separation of homologous chromosmes, begins with synapsis
Term
synapsis
Definition
the pairing up of homologous chromosomes, then referred to as tetrads
Term
crossing over
Definition
homologous chromosomes exchange corresponding segments
Term
meiosis 2
Definition
There is no chromosome duplication
The sister chromatids of each chromosome separate
The result is a total of four daughter cells
Each of which is haploid
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