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ppt3- Histology
Anatomy 2012
196
Anatomy
Undergraduate 4
01/20/2012

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Term
what are the four primary tissues
Definition
epithelial, connective, nervous, and muscular tissues
Term
what is epithelial tissue?
Definition
tissue composed of layers of closely spaced cells that cover organ surfaces or form glands, and serve for protection, secretion, and absorption
Term
what is connective tissue?
Definition
tissue with more matrix than cell volume, often specialized to support, bind, and protect organs
Term
what is nervous tissue?
Definition
tissue containing excitable cells specialized for rapid transmission of coded information to other cells.
Term
what is muscle tissue?
Definition
tissue composed of elongated, excitable cells specialized for contraction
Term
four steps of tissue section preparation
Definition
fixation
section
stain
observation
Term
Describe intercellular material and blood vessel counts in epithelium tissue
Definition
little intercellular material
no blood vessels
Term
characteristics of epithelium
Definition
1+ layers
closely adhered cells
form surfaces
avascular
basement membrane
basal and apical surface
Term
functions of epithelium
Definition
barrier
secretion
absorption
excretion
sensory reception
Term
what does epithelium rest upon?
Definition
basement membrane
Term
what composes the basement membrane?
Definition
adhesive glycoproteins and other extracellular material
Term
what is the role of the basement membrane?
Definition
the adhesive glycoproteins an other extracellular material separates it from and binds it to connective tissue

binds growth factors that affect epithelial development and maintenance
Term
[image]
Definition

1. dead squamous cells

2. living epithelial cells

3. connective tissue

Term
[image]
Definition
1. living epithelial cells
Term
types of epithelium tissue cells
Definition
simple squamous epithelium
simple cuboidal
simple columnar
pseudostratified columnar
stratified squamous
stratified cuboidal
transitional epithelium
Term
what are simple epithelium?
Definition
all cells contact basement membrane
Term
what are stratified epithelium?
Definition
some cells rest atop others without touching the basement membrane
Term
what are simple squamous epithelium?
Definition
single layer of flat, scale-like cells
Term
characteristics of simple squamous epithelium
Definition
cells fit tightly together
easily damaged
found where diffusion takes place
Term
where are simple squamous epithelium found?
Definition
serosae of abdominal viscera
endothelium of cardiovascular system (capillaries)
alveoli of the lungs
Term
why is the structure of simple squamous epithelium ideal for diffusion?
Definition
minimizes barrier to diffusion of gases and fluids, and secretes serous fluids.
Term
[image]
Definition
simple squamous cells
Term
define simple cuboidal epithelial cells
Definition
single layer of cube-shaped cells
Term
function of simple cuboidal epithelial cells
Definition
mainly functions in secretion and absorption
Term
where are simple cuboidal cells located?
Definition
kidney tubules
salivary glands
ducts of thyroid
bronchioles
pancreas
liver
Term
[image]
Definition

1. brush border (microvilli)

2. connective tissue

3. basement membrane

4. goblet cell

5. columnar cells

Term
[image]
Definition

1. lumen of kidney tubule

2. (simple) cuboidal epithelial cells

3. basement membrane

Term
what are simple columnar cells?
Definition
single layer of elongated cells
Term
what do simple columnar cells function in?
Definition
functions in secretion and absorption
Term
where are simple columnar cells found?
Definition
lining most of digestive tract/intestines
uterus
stomach
Term
unique characteristics to simple columnar epithelial cells?
Definition
surface often possesses numerous microvilli
contains mucous-secreting goblet cells
Term
what are pseudostratified columnar epithelial cells?
Definition
elongated (columnar) cells arranged to appear as several layers, but is actually just one in which the cell nuclei area at different levels
Term
where are pseudostratified columnar epithelium often found?
Definition
lining upper portion of respiratory tract and oviducts contains numerous goblet cells which secrete mucous that is moved along by cilia
Term
[image]
Definition

1. Cilia

2. Basement membrane

3. Basal cells

4. goblet cells

5. pseudostratified columnar epithelium

Term
what are stratified squamous epithelium?
Definition
many layers; cell division occurs in lower layers and pushes outward as outer layers are lost
range from cuboidal to columnar near basement membrane to squamous at surface
Term
where are stratified squamous epithelium found?
Definition
areas of heavy wear and tear:
epidermis
mouth
anus
esophogus
Term
what is keratinized stratified squamous epithelium?
Definition
has a thick layer of dead cells packed with keratin on the surface.
drier and tougher, found in epidermis
Term
what is nonkeratinized stratified squamous epithelium?
Definition
stratified squamous epithelium that has living cells all the way to surface
characteristic of esophagus and vagina
Term
what is stratified cuboidal epithelium?
Definition
consists of two or more layers of cuboidal cells or cuboidal cells resting atop squamous basal cells
Term
where is stratified cuboidal epithelium found?
Definition
sweat gland ducts
seminiferous tubules of the testis
follicles of the ovary
Term
what are transitional epithelium?
Definition
appearance of cells changes with tension
Term
where are transitional epithelium found?
Definition
lining the urinary system (esp. bladder)
Term
how does transitional epithelium appear when bladder is empty? full?
Definition
empty: numerous layers can be seen
full: few layers are seen
Term
where are transitional epithtelium found?
Definition
urinary tract
within kidney
parts of the urethra
umbilical cord
Term
what do fibroblasts do?
Definition
produce fibers and ground substance
Term
what do macrophages do?
Definition
wandering, resident (?)
Term
what do leukocytes do?
Definition
transform blood into connective tissue (?)
Term
what do plasma cells do?
Definition
produce antibodies
Term
what do mast cells do?
Definition
produce heparin and histamine
Term
what are the 3 primary fiber types?
Definition
collagen
reticular
elastic
Term
what is the role of fluids in oxygen and nturient/wastes in the blood?
Definition
tissue fluid helps diffusion of oxygen and nutrients/wastes that arise from blood vessels, specifically postcapillary venules
Term
describe connective tissue
Definition
type of tissue in which cells usually occupy less space that the extracellular material
Term
what does connective tissue form?
Definition
all:
bones
cartilage
tendons
ligaments
fat
blood
dermis of the skin
filler between other organs
Term
main role of connective tissue?
Definition
bind organs to each other or to support and protect organs
also help:
immunity, movement, storage, heat production, and transport
Term
describe fibrous connective tissue
Definition
exhibits conspicuous fibers in its matrix
Term
types of fibrous connective tissue?
Definition
collagenous
reticular
elastic
Term
common cell types in fibrous connective tissue?
Definition
fibroblasts
macrophages
leukocytes
plasma cells
mast cells
adipocytes
Term
what are the cells and fibers of connective tissue often embedded in?
Definition
a homogenous ground substance that usually has a gelatinous consistency due to three types of large protein-carbohydrate complexes
Term
what are the three large protein-carbohydrate complexes often found surrounding connective tissue cells and fibers?
Definition
glycosaminoglycans
proteoglycans
adhesive glycoproteins
Term
types of loose connective tissue?
Definition
areolar
reticular
Term
describe areolar connective tissue/what does it do?
Definition
abundant, binds epithelia to deeper tissue
Term
what does reticular connective tissue do?
Definition
supports lymphatic organs
Term
characteristic of loose connective tissue?
Definition
abundant ground substance
widely spaced cells and fibers
Term
describe areolar tissue's orientation?
Definition
seemingly random array of collagenous and elastic fibers, scattered fibroblasts, and other cells
underlies most epithelia
fills space between adjacent organs such as trachea and esophogus
Term
useful function for areolar tissue?
Definition
arena for immune defense against invading pathogens
allows nerves and blood vessels to reach other tissues
Term
describe reticular tissue's orientation?
Definition
a loose web of reticular fibers infiltrated with lymphocytes and other cells
Term
what does reticular tissue form a network for?
Definition
lymphnodes
spleen
thymus
bone marrow
Term
describe dense regular connective tissue
Definition
highly organized fibers
less ground substance/more closely packed fibers
Term
main cell type that makes up dense regular connective tissue?
Definition
mainly fibroblasts
Term
what are the two types of dense fibrous connective tissue?
Definition
dense regular
dense irregular
Term
what is made of dense regular connective tissue?
Definition
tendons and ligaments
Term
orientation of dense regular connective tissue?
Definition
bundles of parallel collagen fibers with fibroblasts squeezed between them
Term
useful feature of dense regular connective tissue?
Definition
resists stress and tearing, hence why it makes up tendons and ligaments
Term
describe dense irregular connective tissue
Definition
mostly seemingly randomly arranged, densely packed collagen
Term
what fiber type makes up most of dense irregular and regular connective tissue?
Definition
collagen
Term
what does dense irregular connective tissue form?
Definition
most of the dermis of the skin
sheaths around bones and cartilages
protective capsules around many internal organs
Term
feature of dense irregular connective tissue?
Definition
resists stress
Term
functions of adipose tissue?
Definition
stores energy
protection
Term
what cells mainly constitute adipose tissue?
Definition
adipocytes (fat cells)
Term
describe structure of adipocyte
Definition
has a large central globule of triglyceride surrounded by a thin layer of cytoplasm
Term
what does white (sometimes yellow) fat do?
Definition
serves as energy reserve
cushions and protects organs
holds some organs in place
contours the body
Term
what does brown fat do?
Definition
contains multiple triglyceride globules
serves only to generate heat, especially in infants
Term
what is cartilage?
Definition
supportive connective tissue with a flexible rubbery matrix
Term
what cells are in cartilage?
Definition
chondrocytes
chondroblasts
Term
where are chondrocytes in cartilage found?
Definition
occupy cavities called lacunae scattered throughout collagen matrix
Term
what are the three types of collagen?
Definition
hyaline
elastic
fibrocartilage
Term
what is hyaline cartilage?
Definition
a clear matrix in which fibers are too fine to be easily visible
Term
what makes up most of a fetal skeleton?
Definition
hyaline cartilage
Term
where is hyaline cartilage found in adults?
Definition
covers articular surfaces of many bones
supports larynx, trachea, and bronchi
connects the ribs to the sternum
Term
is cartilage vascular or avascular?
Definition
avascular
Term
describe elastic cartilage
Definition
coarser, more conspicuous fibers made of elastin
Term
where is elastic cartilage found/what does it do?
Definition
shapes the ear pinna
supports epiglottis
Term
describe fibrocartilage
Definition
coarse collagen bundles
often parallel rows of chondrocytes
Term
where is fibrocartilage found?
Definition
intervertebral discs
pubic symphysis where tendons grade into hyaline cartilage at the joints
Term
what is the perichondrium?
Definition
a fibrous sheath that surrounds elastic cartilage and most hyaline cartilage
BUT DOES NOT surround fibrocartilage
Term
types of bone?
Definition
spongy
compact
Term
other name for bone?
Definition
osseous tissue
Term
describe bone
Definition
supportive connective tissue with a calcified matrix
Term
cells found in bone?
Definition
osteocytes
Term
where are osteocytes found?
Definition
occupy lacunae between layers of lamellae
Term
what are canaliculi?
Definition
fine channels that interconnect lacunae in bone
osteocytes communicate through them
Term
what are osteons?
Definition
cylinders of compact bone tissue
lamellae arrange around a central canal in them
Term
where are osteons found?
Definition
compact bone
Term
how is compact bone arranged?
Definition
mostly in cylinders of osteons
Term
what does spongy bone consist of?
Definition
a porous honeycomb of thin plates and spines, ALWAYS covered with a sheet of compact bone
Term
what components make up compact bone?
Definition
central canal
lamellae
osteon
osteocytes
canaliculi
periosteum
Term
what are lamellae?
Definition
thin plate-like structures/alternating layers of different material
Term
describe blood
Definition
fluid connective tissue
Term
function of blood?
Definition
transport cells and solutes from place to place
Term
what elements make up blood?
Definition
erythrocytes
leukocytes (five kinds)
platelets
Term
what are erythrocytes?
Definition
discoidal, oxygen-transporting cells without nuclei
Term
what are leukocytes?
Definition
round, nucleated cells involved in defense
Term
what are platelets?
Definition
small cell fragments involved in blood vessel maintenance and clotting
Term
what are the elements of blood suspended in?
Definition
liquid ground substance called plasma
Term
what is nervous tissue?
Definition
tissue specialized for rapid communication by means of electrical and chemical signals
Term
what constitutes as nervous tissue?
Definition
brain
spinal cord
nerves
neurons
neuroglia
Term
what are neurons?
Definition
nerve cells
Term
what are neuroglia?
Definition
supportive nerve cells
Term
what do neurons do?
Definition
carry out the communicative function of nervous tissue
Term
what makes up a neuron?
Definition
neurosoma
multiple dendrites
usually a single axon too
Term
what is a neurosoma?
Definition
a nerve cell body
Term
what is an axon?
Definition
nerve fiber
Term
what is the role of an axon?
Definition
carry signals away to another cell
Term
what are the types of muscle tissue?
Definition
skeletal
cardiac
smooth
Term
role of muscular tissue?
Definition
specialized to contract when stimulated and to exert force on other tissues
Term
what are examples of muscle tissue's functions?
Definition
body movements
movement of material through the digestive tract
waste elimination
breathing
speech
blood circulation
Term
what is skeletal muscle?
Definition
elongated, striated, multinucleanated cells called muscle fibers
Term
function of skeletal muscle?
Definition
attached to bones and moves joints when it contracts
Term
is skeletal muscle voluntary or involuntary?
Definition
voluntary
Term
what makes up cardiac muscle/what is its arrangement?
Definition
cardiocytes (shorter cells than muscle fibers) with a single nucleus
striated
intercalated discs (cells meet end to end)
Term
cardiac muscle is voluntary or involuntary?
Definition
involuntary
Term
where is the only place cardiac muscle is found?
Definition
heart
Term
what makes up smooth muscle?
Definition
short fusiform cells with a single nucleus
no striation
Term
smooth muscle is voluntary or involuntary?
Definition
involuntary
Term
where does smooth muscle occur?
Definition
iris
skin
blood vessels
walls of the digestive, respiratory, urinary, and reproductive tracts
Term
what makes up smooth muscle?
Definition
short fusiform cells with a single nucleus
no striation
Term
smooth muscle is voluntary or involuntary?
Definition
involuntary
Term
where does smooth muscle occur?
Definition
iris
skin
blood vessels
walls of the digestive, respiratory, urinary, and reproductive tracts
Term
what can both smooth and cardiac muscle cells be called?
Definition
myocytes
Term
what is another name for smooth muscle in the internal organs?
Definition
visceral muscle
Term
what are sphincters?
Definition
rings of muscle (either smooth or skeletal) that regulate body openings and the passage of material through the body
(including the eyelids, stomach, intestines, and urethra)
Term
the three types of glands
Definition
endocrine
exocrine
multi- or unicellular
Term
the three types of glands
Definition
endocrine
exocrine
multi- or unicellular
Term
difference between endocrine and exocrine glands?
Definition
exocrine have ducts usually and release secretions onto the body surface or into the lumen of another organ

endocrine lack ducts and secrete products (hormones) into the bloodstream
Term
what are unicellular glands?
Definition
unicellular glands are isolated gland cells found in predominantly nonglandular epithelia

can be exocrine (i.e. goblet cells) or endocrine (hormone-secreting cells of digestive tract)
Term
what is the stroma?
Definition
a supportive connective tissue framework for glands: a connective tissue capsule surrounds most glands and issues fibrous septa (trabeculae) into the interior of the gland, thus dividing it into lobes and microscopic lobules
Term
what are parenchyma?
Definition
secretory portions of a gland
composed of epithelial cellsgan that secretes substances for use in the body or for elimination as waste
Term
what do serous glands secret?
Definition
thin, watery fluids
Term
what do mucous glands secrete?
Definition
mucin in the gland absorbs water to make/secrete mucus
Term
what are mixed glands?
Definition
both serous and mucous cells
Term
what do cytogenic glands produce?
Definition
whole cells like sperm in the testes or eggs in the ovaries
Term
what is another name for merocrine glands?
Definition
eccrine glands
Term
how do merocrine glands secrete?
Definition
via exocytosis
Term
examples of merocrine glands?
Definition
tear glands
pancreas
gastric glands
Term
how do holocrine glands secrete?
Definition
whole cells disintegrate and become the secretion
Term
what are examples of holocrine glands?
Definition
oil-producing glands of scalp, eyelid
Term
how do apocrine glands secrete?
Definition
predominantly merocrine method, but have a distinct histological appearance
Term
examples of apocrine glands?
Definition
mammary and axillary glands
Term
what are the types of body membranes?
Definition
cutaneous
mucous
serous
endothelium
Term
what is the cutaneous membrane?
Definition
the skin
also the largest membrane of the body
Term
what are mucous membranes?
Definition
composed of a secretory epithelium, a connective tissue lamina propria (areolar connective tissue), and sometimes a muscularis mucosae (smooth muscle layer)
Term
where are mucous membranes found?
Definition
lining passages that open to the exterior (digestive, respiratory, urinary)
Term
what makes up serous membranes?
Definition
simple squamous epithelium on a thin bed of areolar connective tissue
Term
what do serous membranes secrete?
Definition
watery serous fluid
Term
what is endothelium?
Definition
a simple squamous epithelium that lines the inside of the heart and blood vessels
Term
what is mesothelium?
Definition
a simple squamous epithelium of the peritoneum and pleurae
Term
what are synovial membranes?
Definition
fibrous membranes that enclose joint cavities
Term
how do tissues normally grow?
Definition
by means of hyperplasia and hypertrophy
Term
what is hyperplasia?
Definition
cell multiplication
Term
what is hypertrophy?
Definition
enlargement of preexisting cells
Term
how do cells grow pathologically?
Definition
by means of neoplasia
Term
what is neoplasia?
Definition
tumor growth; responsible for pathological tissue growth
Term
what is differentiation?
Definition
the transformation of an unspecialized embryonic tissue into a specialized mature tissue
Term
how can tissues change from one type to another?
Definition
differentiation
metaplasia
Term
what is metaplasia?
Definition
transformation of one mature tissue type to another
Term
how are damaged tissues repaired?
Definition
regeneration
fibrosis
Term
what is regeneration?
Definition
the restoration of preexisting tissue type and its functionality
Term
what is fibrosis?
Definition
formation of scar tissue
Term
how can tissues shrink or degenerate?
Definition
atrophy
necrosis
apoptosis
Term
what is atrophy?
Definition
shrinkage through aging or lack of use
Term
what is necrosis?
Definition
pathological tissue death due to trauma, toxins, infections, etc.
Term
what is apoptosis?
Definition
programmed cell death
Term
what are the two components of any tissue?
Definition
cells and intracellular space
Term
what are the 3 main types of fibers found in the intracellular substance?
Definition
collagen
reticular
elastic
Term
what are the 4 primary tissues?
Definition
epithelium
connective
muscle
nervous
Term
what are the specialized functions of each primary tissue type?
Definition
epithelium: barrier, secretion, reception, excretion, absorption
connective: support, storage, transport, protection, defense, healing
muscle: contraction
nervous: impulse conduction
Term
List the two foremost characteristics of epithelial tissue.
Definition
all cells have a free surface (exhibits polarity), all cells are anchored to a basement membrane
Term
Where is the basement membrane located?
Definition
basal aspect of the cell
Term
how are epithelial cells nourished?
Definition
diffusion
Term
what is the function of the basement membrane?
Definition
mainly a structural element, for support
Term
what are the two main types of epithelial glands?
Definition
endocrine, exocrine
Term
what 2 features are used to classify epithelial glands?
Definition
1. shape of duct (branched vs. unbranched)
2. shape of secretory unit (acinar vs. tubular)
Term
what are the 4 modes of secretory release?
Definition
merocrine
apocrine
holocrine
cytogenous
Term
Name the 3 types of cell membrane specializations, and be able to list examples of each
Definition
1. apical: microvilli & cilia
2. lateral & basal: tight, adhering, and hemidesmosomes junctions
3. communication: gap/nexus junctions
Term
How do the 2 apical cell membrane specializations differ structurally?
Definition
microvilli: core of microfilaments
cilia: core of microtubules, longer than microvilli
Term
what is the function of the two apical cell membrane specializations?
Definition
microvillli: increase surface area for absorption and secretion
cilia: move things over cell surface by beating in a wave-like fashion
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