Term
| What are six steps to the approach of a patient with a hemorrhagic disorder? |
|
Definition
1) systemic?
2) spontaneous?
3) Severity
4) Age at presentation
5) Family Hx
6) Underlying disorder |
|
|
Term
| What is the hallmark of thrombocytopenia? |
|
Definition
|
|
Term
| What platelet count is considered safe? |
|
Definition
|
|
Term
| What is ITP characterized by? |
|
Definition
| rapid destruction of platelets by autoantibody IgG |
|
|
Term
| What is the most cause of mortality in ITP patients? |
|
Definition
|
|
Term
| What are some treatments for ITP? |
|
Definition
1) avoid aspirin/NSAIDS
2) Prednisone
3) if Prednisone fails - splenectomy
4) IV immune globulin |
|
|
Term
| What are the 5 major manifestations of TTP? |
|
Definition
1) severe microangiopathic hemolytic anemia
2) moderate-severe thrombocytopenia with increased marrow megakaryocytes
3) Fever
4) CNS signs/symptoms
5) Renal Disease |
|
|
Term
| What are 4 abnormalities of platelet function? |
|
Definition
1) myeloproliferative diseases and associated platelet abnormalities
2) Uremia
3) Liver disease
4) Drug-induced platelet disorders |
|
|
Term
| platelet count >500,000 with normal function is what? |
|
Definition
|
|
Term
| What are vascular purpuras characterized by? |
|
Definition
| cutaneous hemorrhage, occasionally associated with mucosal bleeding |
|
|
Term
| What is the most common hereditary bleeding disorder? |
|
Definition
|
|
Term
| What is the most common type of Von Willebrand disease? |
|
Definition
| Type 1: vWF antigen, Factor VII, and ristocetin cofactor levels are all decreased |
|
|
Term
| What is effective to treat traumatic bleeding or prior to surgery in those with Von Willebrand disease? |
|
Definition
DDAVP
*stimulates release of vWF from endothelial cells |
|
|
Term
| What is deficient or defective in Hemophilia A? |
|
Definition
|
|
Term
| What is an important aspect for diagnosis of hemophilia A? |
|
Definition
| family history of bleeding |
|
|
Term
| What can be given to patients with Hemophilia A? |
|
Definition
| cryoprecipitate - factor VII replacement |
|
|
Term
| What is the most common acquired hemorrhagic disorder? |
|
Definition
|
|
Term
| What is the general pathophysiology of DIC? |
|
Definition
| massive activation of clotting cascade overwhelming anithtrombotic mechanisms giving rise to uncontrolled thrombin generation |
|
|
Term
| What diagnostic findings suggest DIC? |
|
Definition
1) microangiopathic RBCs
2) moderate thrombocytopenia |
|
|
Term
| What three populations have a higher incidence of acquired hemophilia? |
|
Definition
1) elderly
2) during pregnancy
3) postpartum |
|
|
Term
| Where are the most frequent hemorrhages related to severe liver disease? |
|
Definition
1) esophageal
2) GI
3) gastric
4) peptic Ulcer |
|
|
Term
| What is a revealing clue postoperatively of a systemic malfunction? |
|
Definition
| bleeding at multiple sites, particular areas other than surgical wound |
|
|
