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Physiology:Respiratory
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52
Physiology
Graduate
08/16/2009

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Term
CONDUCTING ZONE
Definition
CONDUCTING AIRWAYS THAT BRING AIR INTO AND OUT OF THE LUNGS.
Term
RESPIRATORY ZONE
Definition
AREA LINED WITH ALVEOLI, WHERE GAS EXCHANGE OCCURS
Term
CONTENTS OF CONDUCTING ZONE:
Definition
NOSE, NASOPHARNYX, LARNYX, TRACHEA, BRONCHI, BRONCHIOLES, TERMINAL BRONCHIOLES
Term
WHAT ARE THE EFFECTS OF THE SYMPATHETIC/PARASYMPATHETIC ON THE SMOOTH MUSCLE OF THE CONDUCTIVE AIRWAY?
Definition
SYMPATHETIC:ACTIVIATE b2 RECEPTORS ON BRONCHIAL SMOOTH MUSCLE LEADING TO DIALATION OF THE AIRWAYS.
PARASYMPATHETIC: ACTIVATE MUSCARINIC RECEPTORS LEADS TO CONSTRICTION OF AIRWAYS.
Term
BETA 2 RECEPTORS
Definition
CONDUCTIVE AIRWAY SMOOTH MUSCLE RECEPTORS FOR ADRENERGIC MOLECULES OF SYMPATHETIC RESPONSE; LEAD TO DIALATION
Term
MUSCARINIC RECEPTORS:
Definition
CONDUCTIVE AIRWAY SMOOTH MUSCLE RECEPTOR FOR CHOLENERGIC MOLECULES OF THE PARASYMPATHETIC SYS; LEADS TO CONSTRICTION.
Term
ISOPROTERENOL:
Definition
BETA 2 ADRENERGIC AGONIST LEADING TO SYMPATHETIC RESPONSE.
Term
NAME THREE BETA 2 ADRENERGIC AGONISTS:
Definition
1. EPINEPHRINE
2. ISOPROTERENOL
3. ALBUTEROL
Term
MAIN FXN OF ALVEOLI:
Definition
GAS EXCHANGE
Term
NAME THE ALVEOLAR EPITHELIAL CELLS:
FXN:
Definition
TYPE I & II PNEUMOCYTES
TYPE II SYNTHESIZE PULMONARY SURFACTANT FOR REDUCTION OF SURFACE TENSION OF ALVEOLI.
Term
NAME THE PHAGOCITIC CELLS OF THE ALVEOLI:
FXNl
Definition
ALVEOLAR MACROPHAGES
KEEP ALVEOLI FREE OF DUST AND DEBRI; ALVEOLI HAVE NO CILLIA FOR THIS FXN.
Term
SPIROMETER:
Definition
MEASURES STATIC VOLUMES OF THE LUNG
Term
TIDAL VOLUME:
Definition
NORMAL, QUIET INSPIRATION/EXPIRATION
500mL (volume of air that fills the alveoli + volume of air that fills the airways)
Term
INSPIRATORY RESERVE VOLUME:
Definition
ADDITIONAL VOLUME THAT CAN BE INSPIRED ABOVE TIDAL VOLUME (apx 3000mL)
Term
EXPIRATORY RESERVE VOLUME:
Definition
ADDITIONAL VOLUME THAT CAN BE EXPIRED BELOW TIDAL VOLUME (1200mL)
Term
RESIDUAL VOLUME (RV):
Definition
VOLUME REMAINING AFTER A MAXIMAL FORCED EXPIRATION (1200mL); CAN'T BE MEASURED BY SPIROMETER
Term
NAME FOUR LUNG CAPACITIES:
Definition
1. INSPIRITORY CAPACITY (IC)
2. FUNCTIONAL RESIDUAL CAPACITY (FRC)
3. VITAL CAPACITY (VC)
4. TOTAL LUNG CAPACITY (TLC)
Term
INSPIRATORY CAPACITY (IC)
Definition
TIDAL VOLUME + INSPIRATORY RESERVE VOLUME
Term
FUNCTIONAL RESIDUAL CAPACITY (FRC)
Definition
EXPIRATORY RESERVE VOLUME (ERV) + RESIDUAL VOLUME = apx 2400mL
THAT IS REMAINING IN THE LUNGS AFTER A NORMAL TIDAL VOLUME IS EXPIRED
Term
VITAL CAPACITY (VC)
Definition
INSPIRATORY CAPACITY + EXPIRATORY RESERVE VOL. = apx 4700mL ; VOL. THAT CAN BE EXPIRED AFTER MAX. INSPIRATION.
Term
TOTAL LUNG CAPACITY (TLC)
Definition
VITAL CAPACITY + RESIDUAL VOL.= apx 5900mL
Term
WHICH LUNG CAPACITY IS OF GREATEST INTERSEST? WHY?
Definition
FRC; IT IS THE RESTING OR EQUILIBRIUM VOL. OF THE LUNGS
Term
2 WAYS TO MEASURE THE FRC:
Definition
HELIUM DILUTION & BODY PLETHYSMOGRAPH
Term
CELL TYPE THAT CONTRIBUTES 95% OF THE STRUCTURE TO ALVEOLI
Definition
TYPE 1 PNEUMOCYTES
Term
WHICH CELLS SECRETE SURFACTANT?
Definition
TYPE II PNEUMOCYTES
Term
SURFACTANT FUNCTION
Definition
DECREASES SURFACE TENSION ALLOWING ALVEOLI OF SMALL DIAMETER NOT TO COLLAPSE
Term
AIR FLOW EQUATION:
Definition
Q=dP/R
Term
HOW DOES RADIUS OF AIRWAY AFFECT RESISTANCE?
Definition
SMALL REDUCTIONS IN r CAN GREATLY INCREASE R
Term
WHERE DOES THE GREATEST AMOUNT OF AIRWAY RESISTANCE OCCUR?
Definition
LARGER BRONCHIOLES
Term
RECEPTORS OF SM THAT ARE RESPOSIBLE FOR BRONCHDILATION:
Definition
BETA 2 RECEPTORS; ADRENERGIC
Term
RECEPTORS ON SM THAT ARE RESPONSIBLE FOR BRONCHCONSTRICTION
Definition
MUSCARINIC; CHOLINERGIC, PARASYMPATHETIC
Term
HIGH LUNG VOLUMES: DECREASE OR INCREASE R?
Definition
DECREASE
Term
WHAT 2 FORCES ARE RESPONSIBLE FOR NEG PRESSURE MAINTAINED IN THE PLEURAL SPACE?
Definition
ELASTIC RECOIL OF TISSUE AND LYMPHATIC DRAINAGE OF PLEURAL FLUID
Term
DEFINE PNEUMOTHORAX
Definition
AIR INTRODUCED INTO THE PLEURAL SPACE; LUNGS COLAPSE CHEST WALL SPRINGS OUT
Term
WHAT IS THE MAJOR COLLAPSING FORCE IN THE LUNG?
Definition
SURFACE TENSION FOLLOWED BY ELASTIN
Term
DEFINE DPPC:
Definition
DIPALMITYL PHOSPHATIDYLCHOLINE MAKES UP SURFACTANT
Term
WHEN DEALING WITH SURFACE TENSION AS DIAMETER DECREASES SURFACE TENSION & COLLAPSING FORCE:
Definition
INCREASE
Term
WHEN DOES SURFACTANT SYNTHESIS BEGIN IN FETUS?
Definition
24WKS
Term
SURFACTANT IS ALWAYS PRESENT AT WHAT WEEK GESTATION?
Definition
35
Term
GIVEN THE PROPERTIES OF SURFACE TENSION WHY IS WURFACTANT EVEN MORE IMPORTANT IN INFANTS?
Definition
ALVEOLAR DIAMETER IS MUCH SMALLER, THEREFORE COLLAPSING FORCES ARE MUCH GREATER
Term
2 TREATMENTS FOR NEONATAL REPIRATORY DISTRESS:
Definition
1. POSITIVE PRESSURE OXYGEN
2. INTRODUCE SURFACTANT INTO LUNGS
Term
DEFINE TRANSPULMONARY PRESSURE
Definition
PRESSURE DIFFERENCE BTWN ALVEOLAR PRESSURE AND PLEURAL PRESSURE; THE GREATER THE PRESSURE DIF THE GREATER THE TENDENCY FOR ALVEOLI TO INFLATE
Term
MINUTE VENTILATION FORMULA
Definition
Vt(TIDAL VOL) x BREATHS/MINUTE = MINUTE VENTILATION
Term
PERSONS CAN SURVIVE FOR A SHORT TIME WITH A MINUTE VENTILATION AS LOW AS:
Definition
1.5L/MIN
Term
NORMAL MINUTE VENTILATION =
Definition
6L/min
Term
2 FACTORS CONTRIBUTING TO PHYSIOLOGIC DEAD SPACE:
Definition
ALVEOLI NOT PARTICIPATING IN GAS EXCHANGE AND THE CONDUCTING AIRWAYS
Term
VOLUME OF NORMAL PHYSIOLOGIC DEAD SPACE
Definition
150ml
Term
4 ASSUMPTIONS IN CA;CULATING PHYSIOLOGIC DEAD SPACE:
Definition
1. CO2 IN EXPIRED AIR IS COMMING FROM VENTILATED ALVEOLI
2. NO CO2 IN INSPIRED AIR
3. PHYSIOLOGIC DEAD SPACE DOES NOT CONTRIBUTE CO2
4. [CO2]IN ALVEOLI = [CO2] IN ARTERIAL
Term
PHYSIOLOGIC DEAD SPACE FORMULA:
Definition
Vd=Vt(PaCO2-PECO2)/PaCO2
Term
DEFINE ALVEOLAR VENTILATION RATE
Definition
MINUTE VENTILATION RATE CORRECTED FOR PHYSIOLOGIC DEAD SPACE
Term
HOW IS ALVEOLAR VENTILATION USED
Definition
MAJOR FACTOR IN DETERMINING ALVEOLAR O2 AND CO2 CONCENTRATIONS
Term
ALVEOLAR VENTILATION FORMULA
Definition
Va = (Vt - Vd) x BREATHS/min
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