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Physiology Intro to Neuro
Testing
6
Physiology
09/12/2009
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Term
Ionic composition in and out of cell
 Definition
Ion Inside Outside
Na 15.0 150.0
K 150.0 5.5
Cl 9.0 125.0
Ca 0.001 2.0
H 10-7 10-7
Term
Importance of Calcium
 Definition
Ca-volted (AP)
Ca-ligand (ACh)
Ca-store operated
2H+-Ca exchanger
Ca as secondary messenger: Ca-Calmodulin in smooth muscle; Ca in release of vesicles; Ca in IP3/Ca phosphorylation
Term
Metabotropic
 Definition
slow; G-protein linked
Term
Ionotropic
 Definition
fast; ligand activated
Term
GABA a receptor
 Definition
Cl- ionotropic; hyperpolarization
Term
GABA b receptor
 Definition
metabotropic; slows Ca uptake; negative feedback mechanism