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Physiology-Digestion
Exam 2
37
Physiology
Undergraduate 3
10/28/2013

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Term
why do we eat food?
Definition
to acquire nutrients (for growth, wound repair, etc)
Term
Nutrient acquisition (6 places)
Definition
1. water (large amounts)
2. proteins, amino acids (large amounts)
3. carbohydrates (large amounts)
4. lipids (large amounts)
5. inorganic salts, metals
6. vitamins (organic compounds)
Term
functions of alimentary digestive systems (3)
Definition
1. digest food: breaking it down into usable subunits
2. absorb food: bring those bits into system (bloodstream)
3. remove indigestible and toxic parts: excrete unusable bits
Term
basic processes of digestive system (4)
Definition
1. digestion
2. secretion of fluids
3. absorption
4. motility: moving food through system
Term
digestion process
Definition
mechanical: physical breakdown of food increases it's surface area to have chemical breakdown
chemical breakdown: breaking of bonds (only has access to surface area that touches secretions)
Term
secretion process
Definition
mechanical: lubrication (water, ions, mucous makes up 95% of digestive secretions)

composed of
-water and ions: comes in through blood stream
-mucous: comes in through goblet cells to gastrointestinal lining
-digestive enzymes: break down bonds
Term
digestive enzymes
Definition
carbohydrases, lipases, peptidases: all break down through hydrolysis

buffering: maintaining appropriate environment for enzymes
to work, secretions function to maintain proper pH and temperature
Term
carbohydrases
Definition
polysaccaridases: attack large chain carbohydrates (amylase or [cellulase: breaks down cellulose, is found in bacteria])
glycosidases: break down smaller carbohydrates, dissacharides and monosaccarides
Term
lipases
Definition
break down fats into fatty acids
Term
peptidases
Definition
break down proteins
endopeptidase: big to little proteins
exopeptidase: little to tiny proteins
Term
motility
Definition
how food moves through the digestive system, a transit system
adaptable, complex

the faster food moves through digestive tract, the less time it has for absorption
Term
alimentary canal
Definition
common phylogenetic design for digestive system
canal through organisms, open at both ends
allows for regional specialization (pH, storage)
can eat while still digesting
Term
headgut
Definition
mouthpart: used for ingestion, diverse specialization across species
Buccal cavity: where food enters
pharynx (throat): passage to foregut
associated structuresL mechanical aid, salivary glands, tongues
Term
foregut
Definition
esophagus
stomach: storage of food, start digestion
rugae: muscular folds in walls of stomach that mechanically grind food

monogastric stomach has 2 parts:
-fundus: food storage, some amylase digestion
-antrum: mixing food with secretions, start protein digestion
Term
midgut
Definition
primary site of chemical digestion of proteins, fats, carbs
primary site of absorption of nutrients

three sections in typical vertebrate:
duodenum: receives secretions from liver and pancreas
jejunum
ileum
Term
hindgut
Definition
consolidates indigestible materials (makes feces)
last bit of water absorption
Term
saliva (4 components)
Definition
saliva: increase stimulated by parasympathetic nervous system , decrease stimulated by sympathetic nervous system
water
ions: Na, K, Cl, carbonate (buffers amylase to make an alkaline environment)
amylase
antimicrobial agents: prevent bacteria/viruses from entering system
Term
Gastrin
Definition
hormone
made in G-cells (gastric pits have G-cells)

stimulated by stomach distention, protein
release regulated by pH: decreased pH, decreased gastrin

stimulates motility, release of alkaline fluid in pancreas
stimulates secretion of HCl, pepsinogen, Histamine
Term
Histamine
Definition
paracrine signal
comes from mast/ECL cells in parietal cells of gastric pit

stimulated by gastrin

Gastrin+Histamine stimulates HCl secretion
Term
HCl
Definition
defense mechanism that kills microorganisms
increases acidity which denatures proteins

stimulated by Gastin+Histamine
Term
Pepsin
Definition
peptidase, breaks down proteins
secreted as pepsinogen
HCl+Pepsinogen=pepsin

stimulated by Gastrin, proteins in stomach
Term
Somatostatin
Definition
produced in D-cells

stimulated by low pH

inhibits HCl, Gastrin, Histamine
Term
Mucous
Definition
thick mucousal layer of stomach lining
released by goblet cells
Term
Pancreatic juice
Definition
contains: pancreatic alpha amylase, endopeptidases, lipases, nucleases, bicarbonate (alkaline buffer)
secreted into duodenum

Functions:
1. digestive enzyme, stimulated by CCK
2. increases pH of chyme (alkaline fluid), stimulated by Gastrin and Secretin
Term
Secretin
Definition
hormone
produced in duodenal mucosa (wall of duodenum)

stimulated by acid in small intestine

Functions:
1. increase pancreatic alkaline fluid
2. inhibit gastric motility
3. inhibit gastric secretions from chief and parietal cells
Term
CCK
Definition
hormone
produced in duodenal mucosa

stimulated by fatty acids and amino acids in duodenum

stimulates pancreatic enzyme release
inhibits gastric motility and secretions
Term
Bile
Definition
produced in liver
composed of: water, bile salts, cholesterol, lecithin, inorganic salts, bile pigments
stored in gall bladder

stimulated by CCK, which causes contraction of gall bladder (release of bile into chyme in duodenum)

Function:
1. acts as a buffer
2. waste removal
Term
Intestinal Juice (Succus Entericus)
Definition
alkaline fluid produced in the intestine
-Brunner glands: secrete in duodenum
-Crypts of Lieberkuhn: secrete in small intestine

stimulated by distention reflex
Term
muscle structure (5)
Definition
submucosa: tissue for structure
mucosa: absorptive layer, can use endocytosis to absorb
longitudinal muscle
circular muscle
circular fold
Term
submucosa
Definition
has thick, circular layer and projections into mucosa
increased surface area allows for mucosa attachment
Term
mucosa
Definition
has villi inside that increase surface area for absorption
within each villus is a capillary bed and lymph system that provides blood circulation in the intestines
Term
Brush border
Definition
made of microvilli and glycocalyx (extensions of microvilli)
contain digestive enzymes
contain motor proteins: actin and myosin that cause microvilli to move and churn chyme, which maximizes absorption
Term
simple diffusion
Definition
diffusion of water through open channels
Term
facilitated diffusion
Definition
diffusion by transport protein
Term
active transport
Definition
transport by ATP (direct pump), linked to transport proteins
Term
absorption in blood stream
Definition
sugars and amino acids go through hepatic portal vein straight to liver where toxin break down occurs
Term
absorption in lymph system
Definition
Lacteal: 80% of fatty acids diffuse into cell (in packaged version of cholesterol) into chylomicrons
chylomicrons are removed via exocytosis into lacteal
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