Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Growth Hormone is released by: |
|
Definition
- amino acids
- protein meal
- starvation- ghrelin
- hypglycemia
- exercise
- sleep |
|
|
Term
| exercise and sleep is when growth hormone is tested to see if anterior pituitary is working |
|
Definition
|
|
Term
| Effects of growth hormone: |
|
Definition
- increased anabolism: amino acid transport, protein synthesis, RNA synthesis
- Slows catabolism
- increases activity of hormone sensitive lipase
- decreases CHO utilization |
|
|
Term
| Growth hormone has an anti-___ effect in that it spares ___ for the brain. So individuals with high growth hormone levels become ___ resistant and can develop Diabetes. |
|
Definition
- anti-insulin effect
- spares CHO
- insulin resistant |
|
|
Term
| Hormone sensitive lipase is upregulated by __ ___. This causes the release of ___ ___ during hypoglycemia (alternate fuel to spare glucose for the brain). |
|
Definition
- growth hormone
- fatty acids |
|
|
Term
| By what two methods does growth hormone spare blood glucose: |
|
Definition
- hormone senstive lipase
- decreasing utilization of CHO |
|
|
Term
| IGF-1, aka ___, aka ___ ___. |
|
Definition
- Somatomedin
- Sulfation factor |
|
|
Term
| Both Insulin and IGF-1 are ___. |
|
Definition
|
|
Term
| Insulin like growth factors do what? |
|
Definition
| - mediate action of growth hormone on structural growth |
|
|
Term
| hypothalamus> SRIH (somatostatin release inhibitory hormone) and GHRH (growth hormone releasing hormone)> anterior pituitary releases GH and IGF-1> IGF-1 has negative feedback on GH release from pituitary and negative feedback on release of GHRH on hypothalamus, IGF-1 also stimulates SRIH |
|
Definition
|
|
Term
|
Definition
- negative feedback on release of GH
- negative feedback on release of GHRH
- stimulates SRIH release from hypothalamus |
|
|
Term
| IGF-1 is made in the ___. |
|
Definition
|
|
Term
| hypothalamus> GHRH> anterior pituitary> GH> liver> IGF-1> inhibits GH release and GHRH release and stimulates release of SRIH> stops release of GH |
|
Definition
|
|
Term
|
Definition
- pan (all)
- selective (partial vs. complete)
- Dwarfism (age of onset, androgens) |
|
|
Term
|
Definition
- bad receptors
- no IGF
- Bad IGF |
|
|
Term
|
Definition
| - excess growth hormone during childhood |
|
|
Term
|
Definition
- excess GH after epiphyseal plates have closed, so hands feet and and skull continue to grow
- hyperglycemic
- some of this can be managed with analogs of somatostatin |
|
|
Term
| Excess growth hormone associated with : |
|
Definition
|
|
Term
| Excess growth hormone can be treated how: |
|
Definition
|
|
Term
| Corticotropes produce ___ from _____. |
|
Definition
- ACTH
- ProOpioMelanoCortin |
|
|
Term
| Melanocyte stimulating hormone: |
|
Definition
MSH
POMC
ACTH
Relationship to stress and cortisol |
|
|
Term
|
Definition
Peptide Families
Endorphins (POMC)
Enkephalins (Proenkephalin)
Dynorphins (Prodynorphin)
Endomorphins
Receptors
MOR, DOR, KOR
Drug Targets |
|
|
Term
|
Definition
Analgesic
Euphoria
Intestinal Tone (anti-diarrhea strategy) |
|
|
Term
|
Definition
- tolerance
- physical dependence |
|
|
