Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Azole Antifungals (Imadazole - Ketoconazole) |
|
Definition
| excreted in bile and urine; NO CSF |
|
|
Term
| Azole Antifungals (Fluconazole) |
|
Definition
|
|
Term
| 5-Fluorocytosine Antifungals |
|
Definition
|
|
Term
|
Definition
| hepatic metabolism; renal excretion (active in urine---> UTI) |
|
|
Term
|
Definition
| liver-bile feces; metabolized by liver; metabolite is active but more readily excreted; little enterohepatic circulation (unaffected renal insufficiency) |
|
|
Term
|
Definition
| renal excretion without metabolism---> UTI |
|
|
Term
|
Definition
| hepatic metabolism---> conjugated with glucuronic acid (water soluble)---> renal excretion |
|
|
Term
|
Definition
| hepatic metabolism-bile-feces; adjustment not needed for renal impairment |
|
|
Term
| Macrolides (Telithromycin) |
|
Definition
| hepatic metabolism; bile and urine excretion |
|
|
Term
|
Definition
| hepatic metabolism; renal excretion---> non-toxic metabolite---> unaffected by renal insufficiency |
|
|
Term
| Quinupristin/Dalfopristin |
|
Definition
| hepatic metabolism---> bile |
|
|
Term
|
Definition
| hepatic metabolism---> renal excretion |
|
|
Term
|
Definition
|
|
Term
| Flucytosine; Nitrofurantoin; Methenamine |
|
Definition
|
|
Term
| Antimetabolite (Folic Acid Analog: Methotrexate) |
|
Definition
| renal---> renal toxicity if renal impairment |
|
|
Term
|
Definition
|
|
Term
| antiviral (DNA viruses, nonretroviral): Antiherpes Virus (Acyclovir) |
|
Definition
|
|
Term
| antiviral (nonretroviral): Antiinfluenza (Amantadine; Oseltamavir) |
|
Definition
|
|
Term
| antiviral (nonretroviral): Lamivudine |
|
Definition
|
|
Term
| antiretroviral: Zidovudine (AZT) |
|
Definition
| hepatic metabolism--> renal excretion |
|
|
