Term
| What determine the quantative relationship between drug dose and pharmacological effect? |
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Definition
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Term
| What are receptors responsible for? |
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Definition
1) drug action selectivity- Specific drugs can bind to receptor
2) Effects of antagonist |
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Term
| What prevents endogenous ligands from acting on endogenous receptors? |
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Definition
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Term
| Is a receptor a macromolecular or micromolecular target? |
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Definition
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Term
| What is another name for receptor? |
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Definition
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Term
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Definition
| A receptor (receptive substance) is a specialized macromolecular target that binds drug with high affinity and chemical specificity and triggers a cellular response. |
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Term
| Receptor binds drug with high____ and ________ |
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Definition
| Receptor binds with high affinity and chemical specificity |
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Term
| What are the 2 fxns for Receptor? |
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Definition
| 1) Transduction 2) Recognition of ligand |
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Term
| What are the 4 levels of drug action? |
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Definition
| 1) Molecular 2) Cellular 3) Tissue 4) System |
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Term
| What are the immediat targets for drug action? Give examples |
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Definition
| Molecules (proteins) ex. Enzyme, ion channels |
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Term
| Describe the cellular level of drug action (for any type of drug) ? |
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Definition
| Usually at the cellular level drugs cause signal transduction (aka action of drug) |
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Term
| Describe the Tissue level of drug action? |
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Definition
| What happens to tissues after the cellular level has completed (action of the drug). Example the tissue contracts, secretes and other metabolic activity. |
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Term
| Describe the system level of drug action? |
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Definition
| What happens to the overall body after taking the drug. Ex.CV, CNA, GI are altered by the drug. |
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Term
| What are the 4 types of Drug receptors? |
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Definition
1) Ligand- gated receptors
2) G-protein coupled receptors
3)Enzyme linked receptors
4) Intracellular receptors |
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Term
| What are examples of ligand gated receptors? |
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Definition
| Nicotinic, muscuranic, GABA, glycine, 5-HT3 |
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Term
| What is the prevalent transduction component linked to G proteins? |
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Definition
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Term
| What are the two pathways activated via the G-protein receptors? |
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Definition
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Term
| Give example of enzyme linked receptors? |
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Definition
| Tyrosine kinase receptors |
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Term
| What types of ligands usually act on enzyme receptors? |
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Definition
| Insulin and growth factors |
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Term
| What types of ligands act on intracellular receptors? |
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Definition
| thryoid and steroid hormones |
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