Acetaminophen trade name

1. Floricet
2. Zebutal
3. Dolgic Plus

1-2 tablets or capsules every four hours

50mg butalbital, 40mg caffeine, 325-750mg acetaminophen 

1. calcium channel blockers
2. contraceptives
3. corticosteroids
4. cyclosporine
5. disopyramide
6. doxycycline
7. tricyclic antidepressants
8. voriconazole
9. warfin

1. Ultram
2. Ultram ER
3. Ultracet

1. Carbamazepine (decreases level)
2. MAO inhibitors, TCAs, and SSRIs may increase the risk of seizures
3. Naloxone may induce seizures

1. Actiq
2. Duragesic
3. Fentora
4. Sublimaze
5. Onsolis

1. 12.5-25 ug/hour for 72 hrs (patch)
2. 200ug every three hours (buccally)
3. 50-100 ug (IV single dose)
4. 1ug/kg/hour (IV infusion)

Drugs affecting fentanyl (3)

1. amphetamines (increase analgesic effects)
2. antipsychotic agents (enhance hypotensive effects
3. CNS depressants (increase sedation and dizziness)

1. avoid us within 14 days of using an MAO inhibitor
2. fever can increae absorption
3. controlled substance II
4. abrupt discontinuation may result in an abstinence syndrome
5. every refill needs a perscription

1. 0.03-0.08 mg/kg/dose every 4 hours (oral)
2. 0.015 mg/kg/dose every 3-4 hours (IV, IM, SUB-Q)

1. 2-4 mg every 4 hours (Oral)
2. 0.2-0.6 mg every 2-4 hours (SUB- Q, IV, IM)
3. 1-1.5 mg bolus (epidural)

CNS depressants increase sedation

1. in general well tolerated
2. has hepatotoxicity when given in excess doses
3. mild pain reliever

1. Acetaminophen
2. Butalbital with caffeine and acetaminophen
3. Tramadol

1. CNS depressants
2. MAO inhibitors

1. used for moderate and severe pain
2. controlled substances with risk of abuse (schedule II)

1. fentanyl
2. hydromorphone
3. methadone
4. morphine
5. oxycodone

1. Methadose
2. Dolophine

1. 5 mg every 6-8 hours (oral)
2. 2.5-10 mg every 8-12 hours (IV)

1. CNS depressants: increase sedation
2. NNRTIs and PIs: reduce levels
3. CYP3A4 inducers: reduce levels
4. CYP3A4 inhibitors: increase methadone
5. St. John's wort: reduce levels
6. Grapefruit juice: decrease absorption

1. CNS depressants
2. QTc-prolonging agents
3. Stavudine and didanosine

1. abrupt discontinuation of methadone may result in an abstinence syndrome
2. accumulation can occur with extended use because of long half life
3. discontinue slowly after prolonged use

1. Astramorph
2. Avinza
3. Kadian
4. MS contin
5. Oramorph
6. Roxanol

1. 0.2-0.5 mg/kg/dose every 4 hours (oral)
2. 0.1-0.2 mg/kg/dose every 2-4 hours (IV, IM, SUB-Q)

1. 10-30 mg every 4 hours (oral immediate release)
2. 15-30 mg every 12 hours (controlled release)
3. 2.5-10 mg every 2-4 hours (SUB-Q, IV, IM)
4. Epidural 5 mg

1. alcohol
2. CNS depressants

1. CNS depressants
2. MAO inhibitors and SSRIs

1. May cause physical or psychological dependence
2. Avoid use within 14 days of using an MAO inhibitor
3. Avoid in patients with increase intracranial pressure such as head trauma

1. OxyContin
2. OxyIR
3. Roxicodone

1. 10 mg every 12 hours
2. 1.25 mg every 6 hours

1. management of moderate pain
2. addition of nonopioid is commonly ibuprofen or acetaminophen
3. are classified as controlled substances

Narcotic component binds to opiod mu receptors altering the perception and response to pain combined with a nonnarcotic analgesic that inhibits brain prostaglandin synthesis

1. codeine/acetaminophen
2. hydrocodone/acetaminophen
3. hydrocodone/ibuprofen
4. oxycodone/acetaminophen
5. propoxyphene-n/acetaminophen

1. tylenol 2
2. tylenol 3
3. tylenol 4
4. tylenol with codeine

1. 30-60 mg codeine every 4-6 hours
2. 0.5-1 mg codeine/kg/dose every 4-6 hours

1. CYP2D6 inhibitors
2. CNS depressants
3. Ethanol use
4. Isoniazid

1. Warfarin
2. CNS depressants

1. may cause drowsiness
2. may cause dependence
3. caution durgin breastfeeding
4. controlled substance
5. do not exceed acetaminophen daily dosing recommendations

1. Loret
2. Lortab
3. Vicodin

1. 1-2 tablets every 4-6 hours
2. 0.1-0.2 mg/kg/dose every 4-6 hours

vicodin points to highlight (3)

1. may cause dependence
2. controlled  substance schedule III
3. do not exceed acetaminophen daily dosing recommendations

Vicoprofen

1-2 tablets every 4-6 hours

200 mg ibuprofen, 10 mg hydrocodone

1. anticoagulants: enhanced anticoagulation
2. antihypertensives: decreased effects
3. aspirin: increased bleeding
4. CNS depresents: additive effects
5. Lithium: increased concentration
6. MAO inhibitors and SSRIs

Hydrocodone/Ibuprofen points to highlight (3)

1. may cause drowsiness
2. may cause dependence
3. controlled substance schedule III

1. Endocet
2. Percocet
3. Roxicet
4. Tylox

1-2 tablets every 4-6 hours

5 mg oxycodone, 325 mg acetaminophen

1. CNS depressants
2. Ethanol
3. Isoniazid

1. Warfarin
2. CNS depressants

1. may cause dependence
2. controlled substance schedule II

1. Darvocet-N
2. Propacet

1. used for mild pain syndromes
2. lower incidence of GI ulcers than nonselective NSAIDs
3. complicate by a small increase in cardiovacsular events

1. 100-200 mg twice daily
2. 50 mg  twice daily

1. antacids: decrease absorption
2. corticosteroids: increase GI side effects
3. ethanol: increased GI irritation
4. Fluconazole: increase concentrations

1. ACE inhibitors and angiotensin II receptor blockers
2. Anticoagulants: increase bleeding risk
3. Aspirin: increases bleeding risk
4. Cyclosporin: increase cyclosporine levels
5. Diuretics: decreaes effects
6. Lithium: increased concentrations

1. Watch for signs and symptoms of GI bleeding
2. Take with food
3. Can compromise renal function
4. Use with caution in patients with fluid retentio, congestive hearat failure, renal insufficiency, or hypertension

1. used for mild pain symptoms
2. possess both anti-inflammatory and antipyretic effects
3. Ibuprofen and naproxen are two agents in the class

1. Aspirin
2. Diclofenac
3. Etodolac
4. Ibuprofen
5. Indomethacin
6. Meloxicam
7. Nabumetone
8. Naproxen

1. Corticosteroids: increase GI side effects
2. Ethanol: increased GI irritation

1. ACE inhibitors and angiotensin II receptor blockers
2. Anticoagulants: increase bleeding risk
3. Diuretics: diminish diuretic effect
4. Heparin: increases anticoagulant effect
5. Warfarin: enhances anticoagulant effect
6. Lithium: increased concentrations

1. Be aware of the signs and symptoms of GI bleeding
2. Take with food
3. use with caution in patients with fluid retention, congestive hearat failure, renal insufficiency, or hypertension.
4. Can compromise existing renal function

1. Excedrin
2. Bayer

Aspirin dosing for adults and pediatrics

1. 325-650 mg every 4-6 hours
2. 60-90mg/kg/dose every 4-6 hours

1. Ginkgo biloba: increase antiplatelet effect
2. Other NSAIDs: diminish cardioprotetive effects

Varicella vaccine: increase risk of Reye's syndrome

1. Voltaren
2. Voltaren-XR
3. Cataflam
4. Flector

50 mg three times daily

1. 200-400 mg every 6-8 hours
2. 400-1000 mg/day (extended-release)

1. Motrin
2. Cal dolor
3. NeoProfen

1. 200-800 mg 3-4 times daily
2. 30-50 mg/kg/day

1. Indocin
2. Indocin SR

1. 25-50 mg 2-3 times daily 
2. 0.2 mg.kg (IV)

Mobic

1. 7.5 mg daily up to 15 mg/day
2. 0.125 mg/kg/day up to 7.5 mg/day