Term
Asthma: Non-specific B agonist
SE? |
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Definition
Ispoproterenol
b2 = relax smooth muscles
SE: b1 stimulation (tachycardia) |
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Term
| indicated for acute asthma? |
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Definition
Albuterol
Levalbuterol
(b2 agonists) |
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Term
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Definition
B2 agonist (relax bronchial smooth muscle)
*acute asthma attacks |
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Term
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Definition
B2- agonist
*long acting asthma prophylaxis
SE: tremor/arrythmia |
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Term
Theophylline
1. action
2. use
*blocks action of this drug? |
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Definition
Bronchodilation
inhibit phosphodiesterase, -> decrease cAMP hydrolysis
Asthma Treatment
*blocks action of adenosine (cardio)
P450 inhibitors reduce theophyllines metabolism and thus inc. its toxicity |
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Term
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Definition
Muscarinic agonist
*compete w/ muscarinic receptors-> preventing bronchoconstriction
*TX ASTHMA/COPD |
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Term
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Definition
Mast cell stabilizer (prevent mediator release)
*Prophylaxis for asthma ONLY |
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Term
| 1st line therapy for chonic asthma? |
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Definition
| Corticosteroids (beclomethasone, prednisone) |
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Term
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Definition
inactivates NF-kB (TF that induces TNF-a, among other inflammatory agents)
*1st line therapy for chronic asthma |
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Term
Prednisone
moa?
1st line for? |
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Definition
inactivates NF-kB (TF that induces TNF-a, among other inflammatory agents)
*1st line therapy for chronic asthma |
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Term
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Definition
5-lipoxygenase inhibitor (block conversion of arachadonix acid to leukotrienes)
*LTB4 = neutrophil chemotaxis
*LTC4, LTD4 = increase bronchial tone |
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Term
Zafirlukast
Safe for this age? |
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Definition
Blocks leukotriene receptors
*safe for 5y/o and older
*Aspirin-induced asthma |
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Term
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Definition
Blocks leukotriene receptors
*safe for 1 y/o and older
*Aspirin-induced asthma |
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Term
| *DOC for aspirin-induced asthma |
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Definition
Zafirlukast (5 y/o)
Montelukast (1 y/o) |
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Term
1st generation H1 blockers?
SE? |
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Definition
Diphenhydramine, Dimenhydrinate, Chlorpheniramine
*name contains "-en/-ine" or "-en/-ate"
Allergy
motion sickness
sleep aid
SE:
Sedation (Cross BBB)*
Antimuscarinic
anti-alpha adranergic
anti-serotinergic |
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Term
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Definition
H1 blocker
*Allergy
*Motion sickness
*sleep aid (cross BBB)
SE: anti-muscarinic (mad as a hatter ; cross BBB) |
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Term
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Definition
H1 blocker (1st gen)
*Allergy
*Motion sickness
*sleep aid (cross BBB)
SE: anti-muscarinic (mad as a hatter ; cross BBB) |
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Term
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Definition
H1 blocker
*Allergy
*Motion sickness
*sleep aid (cross BBB)
SE: anti-muscarinic (mad as a hatter ; cross BBB) |
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Term
| 2nd generation H1 blockers |
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Definition
Loratadine, Fexofenadine, desloratadine, Cetirizine
"-adine"
*dont cross BBB |
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Term
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Definition
2nd generation h1 blocker
*allergy use |
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Term
Asthma Treatment
1. acute attack?
2. long-acting prophylaxis?
3. first line for chronic?
4. Asprin-Induced? |
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Definition
Acute
1. Albuterol
2. Levalbuterol
prophylaxis
1. Salmeterol
2. Cromyln (inhibit mast cell degranulation)
chronic asthma
1. Prednisone
2. Beclamethasone
Apsrin Induced
1. Zafirlukast
2. monteleukast |
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Term
N-Acetylcysteine
use?
antidote? |
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Definition
USE:
1. Loosen Mucus Plugs in CF pts
2. Kidney protection from contrast-induced nephropathy
Antidote: Acetaminophen toxicity
a. regenerate Glutathione |
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Term
Bosentan
1. action
2. use? |
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Definition
action: Inhibits Endothelin-1 receptors
a. decreasing PVR
use: Pulmonary HTN |
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