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Pharmacology: Chapter 4
Cardiovascular Emergencies Pharmacology
45
Pharmacology
Graduate
02/16/2014

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Term
aspirin (Class)
Definition
1. Platelet Inhibitor

2. Anti- Inflammatory
Term
aspirin (dosage)
Definition
160 mg to 325mg
Term
aspirin (administration)
Definition
PO (chewed if possible)
Term
TPA (class)
Definition
thrombolytic agent
Term
TPA (Mechanism of action)
Definition
1. Binds to Fibrin-bound plasminogen at the clot site
2. converts plasminogen to plasmin
3. plasmin digest the fibrin strands at the clot site,
4. restores perfusion
Term
TPA (Dose :adults)
Definition
total dose of 100 mg
1. 10 mg IV bolus in 2 minutes
2. 50 mg over 1 hour
3. 20 mg over 2nd hour
4. 20 mg over 3rd hour
Term
TPA (supplied)
Definition
1. 20 mg with 20 mL diluent vial
2. 50 mg with 20 mL diluent vial
Term
epinephrine (class)
Definition
sympathomimetic
Term
epinephrine (MOA)
Definition
alpha/ Beta Inhibitors
Term
epinephrine (Dose)
Definition
1 mg iv push, repeat 3-5 mins, no max dose, 20 cc flush after dose.
Term
vasopressin (class)
Definition
antidiuretic hormone
Term
Vasopressin ( MOA)
Definition
potent vasoconstictor when given in high doses
Term
Vasopressin (doses)
Definition
40 unit one time dose IV/IO (in first or second dose of epi)
Term
Lidocaine (class)
Definition
antiarrythmic
Term
lidocaine (MOA
Definition
Slows depolarzation
Term
Lidocaine (dose)
Definition
1-1.5 mg/kg to a max of 3mg/kg
Term
atropine (class)
Definition
anticholinergic agent
Term
atropine (MOA)
Definition
parasympatholytic: inhibits acetylcholine at receptor sites
increases HR in life threatening bradyarrhythmias
Term
atropine (dose)
Definition
0.5 mg if alive
1.0 mg if dead
Term
atropine (interaction problems)
Definition
1. digoxin
2. cholinergics
3. physostigmine
4. effects enhanced
- antihistamines
- procainamide
- quindine
- antopsychotics
- benzodiazpines
- antidepressants
Term
magnesium (class)
Definition
elctrolyte
Term
magnesium (MOA)
Definition
reduces striated muscle contractions
Term
magnesium (dose)
Definition
1-2 g (2-4 mL of a 50% solution) diluted in 10 mL of D5W IV/IO over 5-20 mins
Term
Adesnosine (Class)
Definition
  • Endogenous nucleotide
Term
Adenosine (MOA)
Definition
  • Slows conduction time throught the av node
  • Slows HR
Term
Adenosine (dose)
Definition
• 6 mg over 1-3 seconds
- followed by 20mL flush
- if no response after 1-2mins
- 12 mg over 1-3 minutes
- if no response, repeat 12mg
• total maximum dose 30 mg
Term
Amiodarone (class)
Definition
  • Antiarrhythmic 
Term
Amiodarone (MOA)
Definition
  • Blocks sodium channels 
  • Blocks myocardial potassum channels
Term
Amiodarone (dose: adult)
• Vfib/ pulseless, Vtach unresponsive to CPR, Defib, and vasopressors
Definition
• 300 mg IV/IO push
• repeat dose 3-5 mins later:
150 mg IV/IO
Term
Amiodarone (dose: adult)
• recurrent life threatening Vent. Arrhythmias.
Definition
• Maximum cumulative dose:
2.2g/ 24 hrs
• Rapid infusion:
150 mg IV/IO over 10 mins.
(15 mg/min), repeat every 10 mins as needed.
• Slow infusion:
360 mg IV/IO over 6 hrs
(1mg/min)
• maintenance dose:
540 mg IV/IO over 18 hrs
(0.5mg/min)
Term
Clacium Chloride (MOA)
Definition
  • Positive Inotropic properties
Term
Calcium Chloride (Class)
Definition
  • Electrolyte 
Term
Calcium Chloride
(Dose: adult)
Definition
• 500 mg to 1000mg
• solution: 5-10 ml in 10%
- for hyperkalemia and calcium channel blocker over dose.
Term
Dobutamine (Class)
Definition
  • Sympathomimetic 
  • inotropic agent 
Term
Dobutamine (MOA)
Definition
  • Increases myocardial contractilitiy and stroke volume 
Term
Dobutamine (dose: adults/ peds)
Definition
•Iv infusion at 2- 20 ug/kg/min
Term
Dopamine (class)
Definition
  • Sympathomimetic
  • Inotropic agent 
Term
Dopamine (MOA)
Definition
  • Increases systemic vascular resistence 
  • dilates renal and splanchnic vasculature
  • Increases myocardial contractility and stroke volume
Term
Dopamine (dose: adult/ped)
Definition
• 2-20 ug/kg/min titrated to effect
Term
Zofran (Class)
Definition
  • 5-HT3 receptor antagoinst 
Term
Zofran (MOA)
Definition
  • Blocks action of serotonin (causes n/v)
Term
Ondansetron Hydrochloride
(Zofran)
Dose: adult/ Peds
Definition
• 4mg IV or IM (repeat every ten mins)
• 0.1 mg/kg IV or IM
Term
Verapamil (Class)
Definition
  • Antiarrhythmic 
Term
Verapamil (MOA)
Definition
  • Calcium Channel Blocker
  • Class IV antiarrhythmic
  • Prolongs AV nodal refractory 
  • Dilates Coronary artiers and arterioles
Term
Verpamil (Dose: Adult)
Definition
  • 2.5 - 5.0 mg IV blous over 2 minutes
  • Repeat dose: 5-10 mg may be given every 15-30 minutes
  • maximum dose: 20 mg 
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