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Pharmacology
Diuretics
18
Biology
Undergraduate 2
03/19/2009

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Term
Diuretics
Definition
Action:blockade of Na and Cl reabosorption->preven water reabsorbtion, water and solutes excreted
Term
Look Diuretics: Furosemide (Lasix)
Definition
Potent diuretic, works on ascending loop of Henle, produces diuresis and decreases blood pressure (edema, HTN)
Term
Loop Diuretics drug interactions
Definition
ototoxic drugs, digoxin, antihypertensive, lithium
Term
early symptoms of hypokalemia
Definition
anorexia, lethargy, mental confusion, nausea, muscle weakness, hypotension
Term
late symptomso f hypokalemia
Definition
neurophathy, paralytic ileus, secondary alkalosis, cardiac dysrhythmias
Term
foods high in potassium
Definition
rainsins (dried fruits), strawberries, watermelon, cantaloupe, oranges, beets, greens, tomatoes, muchsrroms, beans, peas,turkey, fish, beef
Term
Thiazides
Definition
not as effective as loop diaretics (only 10% where loop is 20%, inhibit aldosterone (save K+)
Term
Potassium sparing diruetics
Definition
spironolactone, blocks aldosterone receptors in collecting ducts and tubules (interphere with Na/K exchange), weak diuretics (use with thiazides)
Term
mannitol
Definition
most effective, use of somotic force to pull fluid out (IV administration) for ICP and ARF, caution with hear problems (circulatory overload, bp)
Term
Potassium administration
Definition
IV-> dilue and give slowly, NEVER RAPID PUSH = toxic arrhthmia
Term
ACE Inhibitors (captoPRIL,enalaPRIL,lisinoPRIL)
Definition
uses: HTN, heart failure, MI (blok renin process, decrease BP and work load) (1) prevents vasoconstriction, (2) fluid loss
Term
Action of Ace
Definition
-inhibits ACE enzyme to convert angiotensin from I to II, inhibits kinase II (bradykinin)
Term
ACE inhibitor side effects
Definition
hyperkalemia, hypersensitivity, hypotension, neutropenia, cough (bradykinin), angioedema (capillary permiability)
Term
Angiotensin II Antagonists (losartan, valsartan)
Definition
blocks the binding of angiotensin II to receptors on vascular smooth muscles, decreased vasoconstriction and renin (vasodilation and fluid loss)
Term
calcium channel bockers (verapamil, nifedipine)
Definition
inhibit influx of calcium ions accross cell membranes (myocardial cells, vascular smooth muscles
Term
verapamil (calan)
Definition
calcium channel blocker, used for cardiac arrhythmias, angina, hypertension, decreases hearth work load (may cause N & C, diziness, less HR)
Term
nifepine (procardia)
Definition
calcium channel blocker, primary action on vascular smooth muscle; no antiarrhythmic affects, causes lower BP and reflex tachycardia (increase HR and contractility)
Term
nursing considerations for calcium channel blockers
Definition
monitor vitals (hold drug if HR <60, systolic BP < 90), prevent orthostatic hypotention, monitor for CHF
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