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Pharmacology
Pharm Tables from First Aid
52
Medical
Not Applicable
11/28/2012

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Term
P-450 Inducers
Definition
Pneumonic = Barb Steals Phen-phen and Refuses Greasy Carbs Chronically:

1) Barbituates
2) St. Johns Wort
3) Phenytoin
4) Rifampin
5) Griseofulvin
6) Carbamazepine
7) Chronic alcohol use
Term
P-450 Inhibitors
Definition
MAGIC RACKS + quinine

1) Macrolides
2) Amiodarone
3) Grapefruit juice
4) Isoniazid
5) Cimetidine
6) Ritonavir
7) Acute alcohol abuse
8) Ciprofloxacin
9) Ketoconazole
10) Sulfonamides
11) Quinidine
Term
Sulfa Drugs (list)
Definition
Popular FACTSSS

1) Probenecid
2) Furosemide
3) Acetazolamide
4) Celecoxib
5) Thiazides
6) Sulfonamide antibiotics
7) Sulfasalazine
8) Sulfonylureas
Term
- azole
Definition
antifungals - inhibit cytochrome P-450 in fungus preventing synthesis of ergosterol
Term
- cillin
Definition
penicillins
Term
- cycline
Definition
antibiotics - protein synthesis inhibitors (30S) - in class of tetracyclines
Term
- navir
Definition
protease inhibitor (antimicrobial) - used in HIV therapy
Term
- triptan
Definition
5-HT(1B/1D) agonist (used to treat migraine) (ex: sumatriptan)
Term
- ane
Definition
inhalation general anesthetic (ex: halothane)
Term
- caine
Definition
local anesthetic (ex: lidocaine)
Term
- operidol
Definition
butyrophenone (a neuroleptic) ex: haloperidol
Term
- azine
Definition
phenothiazine (a neuroleptic, antiemetic) ex: chlorpromazine
Term
- barbital
Definition
a barbituate (ex: phenobarbital)
Term
- zolam
Definition
a benzodiazepine (ex: alprazolam)
Term
- azepam
Definition
a benzodiazepine (ex: diazepam)
Term
- etine
Definition
an SSRI (ex: fluoxetine)
Term
- ipramine
Definition
a TCA (ex: imipramine)
Term
- triptyline
Definition
a TCA (ex: amitryptyline)
Term
- olol
Definition
a Beta antagonist (ex: propranolol)
Term
- terol
Definition
a B2 specific agonist (ex: albuterol)
Term
- zosin
Definition
an alpha 1 antagonist - ex prazosin
Term
- oxin
Definition
a cardiac glycoside (an inotropic agent) (ex: digoxin)
Term
- pril
Definition
an ACE inhibitor (ex: captopril)
Term
- afil
Definition
used to treat erectile dysfxn (ex: sildenafil (viagra))
Term
- tropin
Definition
a pituitary hormone (ex: somatotropin)
Term
- tidine
Definition
an H2 agonist (ex: cimetidine)
Term
Treatment for M. Leprae
Definition
DR. C

1) Dapsone
2) Rifampin
3) Clofazimine
Term
Treatment for M. Tuberculosis
Definition
RIPE

1) Rifampin
2) Isonaized
3) Pyrazinamide
4) Ethambutol
Term
Treatment for M. Avium
Definition
ARES

1) Azithromycin (can be given for prophylaxis)
2) Rifampin
3) Ethambutol
4) Streptomycin
Term
drugs with side effect of gynecomastia
Definition
Pneumonic: Some Drugs Create Awesome Knockers

1) Spironolactone (K+ sparing diuretic)
2) Digitalis (increases heart contractility)
3) Cimetidine (H2 blocker and significant P450 inhibitor)
4) Alcohol
5) Ketoconazole (anti-fungal azole - inhibits ergosterol synthesis by inhibiting P450, used for blastomyces, coccidioides, histoplasma, and candida albicans as well as for hypercortisolism)
Term
Drugs that cause fat redistribution
Definition
glucocorticoids, protease inhibitors
Term
drugs that lead to gingival hyperplasia
Definition
1) Phenytoin (anti-epileptic with lots of side effects. Inactivates Na channel)
2) Verapamil (a CCB = calcium channel blocker)
Term
Drugs that can CAUSE GOUT
Definition
1) Furosemide (a loop diuretic and sulfa drug - inhibits cotransporter for Na, K, and 2Cl)
2) Thiazides (HCTZ)
3) Niacin (vitamin B3)
4) Cyclosporine (immunosupressant - blocks activation of T cells by inhibiting calcineurin - preventing IL2 production)
5) Pyrazinamide (part of RIPE therapy for TB - inhibits mycolic acid production)
Term
Drugs that can cause myopathies
Definition

Fish N CHIPS Give you myopathies.

 

1) Fibrates

2) Niacin (vitamin B3)

3) Colchicine (used to tx gout - inhibits microtubules by inhibiting polymerization of tubulin = impairs leukocyte chemotaxis)

4) Hydroxychloroquine (tx for RA)

5) Interferon alpha (blocks replication of RNA and DNA viruses - used for tx of Hep B and Heb C, and Kaposi's sarcoma)

6) Penicillamine (tx for Wilson's dz and Lead poisoning)

7) Statins

8) Glucocorticoids

Term
Drugs that cause osteoporosis
Definition
Corticosteroids and Heparin
Term
Drugs that cause photosensitivity
Definition
SAT for a photo

1) Sulfonamides
2) Amiodarone
3) Tetracycline
Term
Stevens - Johnson Syndrome (rash)
Definition
bad RASH after a PEC SLAPP

1) Penicillin
2) Ethosuximide (1st line tx for ABSENCE seizures)
3) Carbamazepine
4) Sulfa Drugs (Popular FACTSSS)
5) Lamotrigine
6) Allopurinol
7) Phenytoin
8) Phenobarbital
Term
SLE - like syndrome (drug induced Lupus)
Definition
its not HIPP to have lupus...

1) Hydralazine
2) INH
3) Procainamide
4) Phenytoin
Term
Drug that causes tendonitis, tendon rupture and cartilage damage in kids
Definition
Fluroquinolones
Term
Drug that causes teeth discoloration in kids
Definition
Tetracyclines
Term
Drugs that cause DI (diabetes insipidus)
Definition
1) Lithium
2) Demeclocycline (an ADH antagonist and antibiotic, acts as a diuretic in SIADH and is a tetracycline - bacteriostatic 30S inhibitors)
Term
Drugs that cause Fanconi's syndrome (a proximal tubular reabsorption defect)
Definition
expired tetracycline
Term
Drugs that cause interstitial nephritis
Definition
Methicillin, NSAIDS, and furosemide
Term
Drugs that cause hemorrhagic cystitis
Definition
Cyclophosphamide and Ifosfamide
Term
Drugs that cause SIADH
Definition
1) Carbamazepine
2) Cyclophosphamide
Term
Drugs that cause Cinchonism (headache and tinnitus)
Definition
Quinidine, Quinine
Term
Drugs that cause a parkinson-like syndrome
Definition
Antipsychotics, reserpine, methoclopramide
Term
Drugs that cause Seizures
Definition
Buproprion, imipenem/cilastatin, isoniazid
Term
Drugs that cause Tardive Dyskinesia
Definition
Antipsychotics
Term
Drugs that cause antimuscarinic action
Definition
Atropine, TCAs, H1 blockers, neuroleptics
Term
Drugs that cause disulfiram-like reaction
Definition
Metronidazole, certain cephalosporins, procarbazine, 1st gen sulfonylureas
Term
Drugs that are nephrotoxic/ ototoxic
Definition
Aminoglycosides, vancomycin, loop diuretics, cisplatin
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